A5067587287- Renal Diseases and Glomerulopathies
- Platelet Disorders and Treatments
- Vasculitis and related conditions
- Chronic Kidney Disease and Diabetes
- IgG4-Related and Inflammatory Diseases
- Systemic Lupus Erythematosus Research
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Autoimmune Bullous Skin Diseases
- T-cell and B-cell Immunology
- Mesenchymal stem cell research
- PI3K/AKT/mTOR signaling in cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Lymphocytic Leukemia Research
- Renal function and acid-base balance
- Systemic Sclerosis and Related Diseases
- Renal cell carcinoma treatment
- Complement system in diseases
- Neurological and metabolic disorders
- Liver Disease Diagnosis and Treatment
- Viral-associated cancers and disorders
- Sarcoidosis and Beryllium Toxicity Research
- Acute Myeloid Leukemia Research
Tokyo Women's Medical University
2015-2024
Charlottesville Medical Research
2019
Wake Forest University
2019
Forest Institute
2019
John Wiley & Sons (United States)
2019
Hyogo Medical University
2018
Creative Commons
2018
GGG (France)
2018
The usefulness of the Oxford classification (MEST-C score) for deciding management approach IgA nephropathy (IgAN) remains unclear.Effects steroid therapy on long-term prognosis all 858 patients with IgAN and classified according to each MEST-C score were evaluated using Kaplan-Meier Cox regression analyses. Steroid responder (SRS) nonresponder (SNRS) determined individual pathology scores when steroids found be independently associated, or not, clinical benefits. In addition, effects total...
Abstract Renal fibrosis is one of the largest global health care problems, and microvascular (MV) injury important in development progressive fibrosis. Although conventional cell therapy suppresses kidney via role vasoprotective cytokines, effects are limited due to low retention administered cells. We recently described that transplantation hepatocyte growth factor (HGF)-transgenic mesothelial sheets showed a remarkable survival strong therapeutic rat renal model. Due translational hurdles...
Abstract The Oxford classification for IgA nephropathy (IgAN) was updated in 2017. We have validated the revised considering treatment with corticosteroids/immunosuppressors. In this retrospective analysis, 871 IgAN patients were enrolled. Patients divided into two groups, those treated or without 20-year renal prognosis up to end-stage disease assessed using classification. all patients, survival rate 87.5% at 10 years and 72.6% 20 years. T score alone significantly related Kaplan–Meier...
Abstract Rituximab has been approved in Japan for the treatment of intractable nephrotic syndrome, but cases childhood-onset disease only; its efficacy and safety adult-onset yet to be established. This study was undertaken evaluate rituximab adverse effects patients with minimal change syndrome (MCNS). The involved 32 (mean age at onset: 8.6 years) 19 30.6 frequently relapsing steroid-dependent MCNS, all whom received intravenous drip infusion (375 mg/m 2 body surface area per dose) 4 time...
The Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total in predicting renal prognosis. Altogether, 871 IgAN patients were classified into three groups using (O-grade) (O-grade I: 0-1, II: 2-4, and III: 5-7 points), 10-year prognosis was analysed. clinical findings became significantly severer with increasing O-grades, survival rate by Kaplan-Meier method 94.1%, 86.9%, 74.1% for O-grades I, II,...
Abstract Background IgG4-related disease (IgG4-RD) is a fibroinflammatory that affects multiple organs, including the pancreas, lacrimal glands, salivary periaortic/retroperitoneum, and kidney. Interstitial nephritis typical renal disorder associated with IgG4-RD, but membranous nephropathy also seen in some cases. Case presentation Herein we report on case of 77-year-old male patient nephrotic syndrome lung disease. His serum phospholipase A2 receptor (PLA2R) antibody was positive. biopsy...
Ischemia-reperfusion injury (IRI) is a clinically important cause of acute kidney leading to chronic disease. Furthermore, IRI in renal transplantation still remains risk factor for delayed graft function. Previous studies on have had some limitations, and few the studied therapies been applicable. Therefore, new method treating needed. We examined effects human mesothelial cell (MC) sheets hepatocyte growth (HGF)-transgenic MC (tg MC) transplanted under capsule an rat model compared these...
In patients with systemic lupus erythematosus (SLE), disease activity can persist even after initiating dialysis. However, guidelines for the treatment of SLE dialysis is initiated have not yet been established.We describe case a 54-year-old Japanese woman who was diagnosed at age 12, progressed to end-stage renal (ESRD), and hemodialysis nephritis. persisted hemodialysis. Cyclophosphamide mycophenolate mofetil were administered in addition prednisolone immunoadsorption, but this strategy...
Renal disease is a common complication of rheumatoid arthritis (RA) and can occur secondary to RA or be induced by therapeutic agents. Recently, glomerular deposition galactose-deficient IgA1 (Gd-IgA1) was identified as feature primary IgA vasculitis with nephritis (IgA-VN). We herein report case IgA-VN in an patient whose activity controlled treatment etanercept. To distinguish between caused etanercept, we performed immunostaining renal biopsy sections the Gd-IgA1-specific antibody KM55....
Abstract IgA nephropathy (IgAN) patients often suffer from arterial and/or arteriolar sclerosis (AAS); however, it is unclear whether these features are associated with a poor prognosis. This retrospective cohort study aimed to analyse the prognosis of IgAN AAS and assess treatment renin–angiotensin system inhibitors (RASI) improved their survival. The included 678 patients, who were grouped into AAS0 ( n = 340; absent) AAS1 338; present) groups. Each patient's clinical, laboratory,...
The importance of crescent formation in glomerulonephritis has increased. However, detailed analysis crescentic Asia is scarce. In addition, advances serological diagnostic techniques (antineutrophil cytoplasmic and antiglomerular basement membrane autoantibodies) early diagnosis have reduced the number cases meeting strict definition (>50% glomeruli are crescentic). Therefore, we analyzed clinicopathological features renal prognosis that exhibited at least one lesion.We retrospectively...
Background Tonsillectomy may treat IgA nephropathy (IgAN) by reducing the levels of galactose-deficient IgA1. Therefore, we aimed to analyze long-term effects tonsillectomy on patients with IgAN, as an initial treatment and a at any time in their lives. Methods In this retrospective cohort analysis, 1147 IgAN were grouped according whether they had undergone time, >1 year after renal biopsy (study 1), or within 1 2). The propensity-score matched divided into four groups proteinuria...
The number of patients with diabetic nephropathy is increasing worldwide and it important to understand the underlying pathological mechanisms disease. In early stage nephropathy, hyperglycemic environment leads vascular endothelial cell damage, resulting in overexpression growth factor (VEGF) podocytes renal pathology glomerular hypertrophy, basement membrane thickening, mesangial hyperplasia. thrombotic microangiopathy (TMA) develops progressively worsens some cases severe podocyte damage....
Abstract Background: In patients with systemic lupus erythematosus (SLE), disease activity can persist even after initiating dialysis. However, guidelines for the treatment of SLE dialysis is initiated have not yet been established. Case presentation: We describe case a 62-year-old Japanese woman who was diagnosed at age 12, progressed to end-stage renal (ESRD), and hemodialysis nephritis. persisted hemodialysis. Cyclophosphamide mycophenolate mofetil were administered in addition...