A5006613289- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Metal-Organic Frameworks: Synthesis and Applications
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Sparse and Compressive Sensing Techniques
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Heat shock proteins research
- Advanced SAR Imaging Techniques
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Methane Hydrates and Related Phenomena
- Phagocytosis and Immune Regulation
- interferon and immune responses
Changchun Institute of Applied Chemistry
2023-2025
Chinese Academy of Sciences
2022-2025
State Key Laboratory of Rare Earth Resources Utilization
2025
University of Science and Technology of China
2023-2024
Aerospace Information Research Institute
2022-2024
Although zeolitic imidazolate framework-8 (ZIF-8) has been applied in various tumor therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that ZIF-8 nanoparticles (NPs) can intrinsically induce pyroptosis by a caspase-1/gasdermin D (GSDMD)-dependent pathway. The pyroptotic cell death is accompanied necrosis and immunogenic (ICD) simultaneously for efficient situ immunity initiation. Meanwhile, carbonyl cyanide m-chlorophenyl hydrazone (CCCP), mitochondrial...
Abstract Nowadays, Fenton chemistry‐based chemodynamic therapy (CDT) is an emerging approach to killing tumor cells by converting endogenous H 2 O into cytotoxic hydroxyl radicals (·OH). However, the elimination of ·OH intracellular overexpressed glutathione (GSH) results in unsatisfactory antitumor efficiency. In addition, single mode consuming GSH and undesirable drug loading efficiency cannot guarantee efficient cancer effect. Herein, a simple one‐step strategy for construction Fe 3+...
Abstract Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, simple drug‐free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO 3 NPs), prepared via fast microemulsion method for amplified cancer immunotherapy. The obtained NaHCO regulates lactic acid metabolism through acid‐base neutralization so as to reverse the mildly acidic environment. Additionally,...
Abstract Despite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by the high expression of antioxidant glutathione (GSH) and inadequacy endogenous H 2 O tumors. Herein, metal‐phenolic nanoformulations (FNCP NFs) composed sonosensitizer Chlorin e6 (Ce6), phenolic GSH consumer naphthazarin, Fe 3+ , followed modification PEG2000, are strategically designed fabricated for ultrasound‐boosted cells through triple regulatory pathways. The carrier‐free FNCP NFs can...
Pyroptosis hold great potential in tumor therapy due to its strong immunogenicity. Several strategies, including ion interference (IIT), are developed induce pyroptosis. However, the mechanism by which metal oxoanions induced pyroptosis remained unclear. It was reported that MoO42− ions could stimulate immune responses, but their pyroptosis‐inducing mechanisms were not fully understood. Herein, we synthesized uniform and dispersed silver molybdate (Ag2MoO4) nanoparticles (AMO) via a...
Pyroptosis hold great potential in tumor therapy due to its strong immunogenicity. Several strategies, including ion interference (IIT), are developed induce pyroptosis. However, the mechanism by which metal oxoanions induced pyroptosis remained unclear. It was reported that MoO42− ions could stimulate immune responses, but their pyroptosis‐inducing mechanisms were not fully understood. Herein, we synthesized uniform and dispersed silver molybdate (Ag2MoO4) nanoparticles (AMO) via a...
Abstract Mesoporous silica nanoparticles (MSNs) have been widely praised as nanoadjuvants in vaccine/tumor immunotherapy thanks to their excellent biocompatibility, easy‐to‐modify surface, adjustable particle size, and remarkable immuno‐enhancing activity. However, the application of MSNs is still greatly limited by some severe challenges including unclear complicated relationships structure immune effect. Herein, three commonly used with different skeletons MSN tetrasulfide bonds (TMSN),...
Mild photothermal therapy (MPTT) has emerged as a promising therapeutic modality for attenuating thermal damage to the normal tissues surrounding tumors, while heat-induced upregulation of heat shock proteins (HSPs) greatly compromises curative efficacy MPTT by increasing cellular thermo-tolerance. Ferroptosis been identified suppress overexpression HSPs accumulation lipid peroxides and reactive oxygen species (ROS), but is restricted overexpressed glutathione (GSH) in tumor microenvironment...
Abstract Although zeolitic imidazolate framework‐8 (ZIF‐8) has been applied in various tumor therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that ZIF‐8 nanoparticles (NPs) can intrinsically induce pyroptosis by a caspase‐1/gasdermin D (GSDMD)‐dependent pathway. The pyroptotic cell death is accompanied necrosis and immunogenic (ICD) simultaneously for efficient situ immunity initiation. Meanwhile, carbonyl cyanide m‐chlorophenyl hydrazone (CCCP),...
Abstract Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, simple drug‐free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO 3 NPs), prepared via fast microemulsion method for amplified cancer immunotherapy. The obtained NaHCO regulates lactic acid metabolism through acid‐base neutralization so as to reverse the mildly acidic environment. Additionally,...
Synthetic Aperture Radar (SAR) images are often affected by range ambiguity due to antenna sidelobe characteristics and pulse operating mechanism. The work of suppression focuses on both SAR system design signal processing. On the one hand, ideas have been proposed modify transmitting receiving waveforms block ambiguous energy, such as up down chirp modulation, multiple elevation beams, azimuth phase coding techniques. other processing methods in echo image domains used reduce sparse...