A5022970459- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
- Gut microbiota and health
- Schizophrenia research and treatment
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Diabetes and associated disorders
- Antioxidant Activity and Oxidative Stress
- Cancer-related cognitive impairment studies
- Nerve injury and regeneration
- DNA Repair Mechanisms
- Biochemical effects in animals
- Influenza Virus Research Studies
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Neuropeptides and Animal Physiology
- Neurogenesis and neuroplasticity mechanisms
- Diet, Metabolism, and Disease
- Bipolar Disorder and Treatment
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
Kurchatov Institute
2016-2024
Russian State University for the Humanities
2021
Russian Academy of Sciences
2019
Laboratory of Molecular Genetics
2019
Federal Medical-Biological Agency
2017
Federal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin
2014
The review addresses immunological aspects of schizophrenia, a multifactor disease caused by genetic factors, innate disorders the central nervous system (CNS), including consequences perinatal hypoxia and infections, adverse environmental influences. Neuroinflammation as part pathophysiology schizophrenia is characterized higher transcription CNS inflammatory mediators, excessive activation microglia, inhibition glutamatergic receptors that leads to decrease in number cortical synapses...
was to analyze the immune-inflammatory profile of patients with paranoid schizophrenia and relate it severity negative symptoms MRI data in order identify biomarkers severity, search for new approaches therapy, control its effectiveness.
ApoE is a member of lipoprotein family. It the most common in central nervous system (CNS), secreted by astrocytes, microglia, neurons and immunocompetent cells, including lymphocytes, monocytes macrophages. According to recent data, it has endotheliotropic immunomodulatory functions, regulating inflammatory activation mononuclear phagocytes antigen-induced lymphocyte proliferation. APOE4 allele major genetic risk factor Alzheimer's disease, with prevalence 3-12 times higher those who have...
To study clinical effects of cerebrolysin and its impact on systemic inflammation markers immunity in mild cognitive impairment (MCI).Twenty patients with MCI were treated administered intravenously during 4 weeks. Serum levels immunoglobulins, inflammatory markers, neurotrophic factors measured dynamics controls using ELISA.An effect was found including the older group (mean age 78±1.1 years). An improvement seen 6 and/or 22 weeks after treatment. Four types response to treatment (fast...
to evaluate the levels of cytokines (IFNα, IFNγ, IL-2, Il-4, IL-6, IL-8, IL-10, IL-12, IL-15), IL-1β receptor antagonist (IL-1RA), vascular endothelial growth factor (VEGF) and its antagonist, soluble form 1 (sVEGFR1) in blood serum patients with Alzheimer's disease, early onset (ADEO) late (ADLO), mild cognitive impairment (MCI).Levels interleukins, IL-1RA, VEGF sVEGFR1 were measured 20 AD 11 MCI using ELISA. These parameters compared severity assessed by performance on neurocognitive...
The aims of the project were to study architecture brain's neural networks in process perceiving individual stimuli that are personally significant, evaluate main parameters immunity and systemic inflammation, relate those brain damage markers patterns cognitive-affective disorders patients with schizophrenia.Materials Methods.The involved 35 paranoid schizophrenia 17 people without cognitive impairment.Clinical information about was obtained from database created Alekseev Psychiatric...
Objective To search for the relationship between results of functional imaging, immunological parameters and laboratory markers inflammation in schizophrenia, taking into account cognitive impairment patients, to consider possibility using a multidisciplinary approach diagnosis, treatment prognosis schizophrenia. Material methods The study included 25 patients with schizophrenia 13 healthy volunteers. Psychiatric scales were administered evaluate patient's condition. main indicators humoral...
Schizophrenia is a chronic disease characterized by psychosis, behavioral, cognitive and social impairments. It accompanied structural functional changes in the brain. To confirm significance of morphometric changes, it important to establish relationships between brain, clinical symptoms, level biomarkers reflecting pathogenesis disease, including immunological markers. The aim this work was assess relationship interleukin-6 (IL-6) levels with systemic inflammation, immune activation...
Alzheimer's disease is the most common neurodegenerative in old age. In some cases, it preceded by mild cognitive impairment (MCI). One of important components pathogenesis neurodegeneration chronic neuroinflammation (inflammatory activation microglia and astrocytes brain). Systemic inflammatory response immune dysregulation may contribute to neuroinflammation. The purpose this study was investigate level chemokines other mediators patients with MCI who underwent medical rehabilitation, its...
Amnestic mild cognitive impairment (aMCI) is considered as a possible earliest pre-dementia clinical stage of Alzheimer's disease (AD). Taking into account the prominent role neuroinflammation in pathogenesis AD, it quite important to study immunological markers risk aMCI progression and changes immune parameters patients.To variants AD based on humoral cell immunity, levels key cytokines presence systemic inflammation, explore link between prognosis.One hundred patients with diagnosis aMCI,...
Introduction. Associations of disturbances in innate and adaptive immunity during the clinical course schizophrenia have been found a number studies. Yet, relationship immune parameters systemic inflammation relation to disease its prognosis, remains poorly understood, which highlights an interesting topic for further research. The goal this study was research immuno-inflammatory changes patients with continuous episodic paranoid schizophrenia, assess pathogenetic significance these...
The goal of this research was to study the clinical efficacy course-based neurotrophic therapy in mild cognitive impairment (MCI) and effect on immune parameters patients, assess prognostic value dynamics during year after treatment. 20 patients with MCI receiving intravenous Cerebrolysin (20 infusions 30 ml increasing dose first four days) were examined. Neuropsychological immunological examination carried out immediately before study, 3 months., 6 months 1 end It found that therapy, had a...
The goal of this work was to investigate the associations between IL-17A levels and structural MRI findings clarify immune factors pathogenesis search for biomarkers unfavorable disease course. 45 patients with schizophrenia 30 healthy volunteers were enrolled into study. cytokines (IL-1β, IL-4, IL-6, IL-8, IL-17A) inflammatory markers determined by ELISA. scans performed on a Siemens Magnetom Verio 3T scanner. It found that elevated cytokine are associated morphometric changes in frontal...
In this study, for the first time, data were obtained on architecture of effective connections in extended default neural network patients with schizophrenia and healthy controls. Also, a determination immunological status was performed. At rest, connectomes subjects had significant differences strength connections. Immunological analysis showed that despite clinical improvement after inpatient treatment, most elevated levels markers systemic inflammation activation humoral immunity. next...
To study the relationship of parameters immunity and systemic inflammation with structural magnetic resonance imaging (MRI) in patients mild cognitive impairment (MCI) pre-MCI undergoing neurocognitive rehabilitation to search for candidate markers its effectiveness.
Schizophrenia is a severely disabling and clinically heterogeneous disease that manifests with disorders of thinking, motivation emotions. Negative symptoms schizophrenia include decreased expression emotions, poverty speech, withdrawal from social contacts, anhedonia. They poorly respond to therapy, their severity has the most significant impact on functioning quality life patients. Changes in systemic immunity pronounced negative are studied. We have previously shown relationship elevated...
To study the efficacy and safety of long-term (3 years) course Cerebrolysin therapy in an open comparative as a means potentially capable slowing or preventing transition MCI into dementia, well to analyze possibility preventive effect predicting based on clinical biological parameters.
Schizophrenia is a chronic mental disorder that caused by complex palette of genetic, epigenetic and environmental factors. Some the important components its pathogenesis are systemic inflammation dysfunction immunity, which lead to neuroinflammation, contributing development structural brain changes. Earlier we have shown increase in interleukin-17A levels associated with morphometric changes immune dysregulation schizophrenia. IL17A G-197A (rs2275913) genetic polymorphism involved...
IL-17A is a proinflammatory cytokine involved in pathogenesis of some neuroinflammatory diseases the brain. However, its role schizophrenia poorly understood. Currently, noninvasive neuroimaging techniques are widely used to assess abnormalities brain morphology and interactions neuronal networks schizophrenia. The aim this work was study associations between level morphometric parameters schizophrenia, order clarify immune factors search for biomarkers unfavorable disease course. 45...