A5069491907- Neurobiology and Insect Physiology Research
- Physiological and biochemical adaptations
- Genetics, Aging, and Longevity in Model Organisms
- Invertebrate Immune Response Mechanisms
- Insect Utilization and Effects
- Animal Behavior and Reproduction
- Adipose Tissue and Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- FOXO transcription factor regulation
- Plant biochemistry and biosynthesis
- Genetics and Physical Performance
- Lipid metabolism and biosynthesis
University of British Columbia
2018-2022
Okanagan University College
2021
Triglycerides are the major form of stored fat in all animals. One important determinant whole-body storage is whether an animal male or female. Here, we use Drosophila , established model for studies on triglyceride metabolism, to gain insight into genes and physiological mechanisms that contribute sex differences storage. Our analysis breakdown both sexes identified a role lipase brummer ( bmm ) regulation homeostasis. Normally, flies have higher levels mRNA under normal culture conditions...
Nutrient-dependent body size plasticity differs between the sexes in most species, including mammals. Previous work Drosophila showed that was higher females, yet mechanisms underlying increased female remain unclear. Here, we discover a protein-rich diet augments females and not males because of female-biased increase activity conserved insulin/insulin-like growth factor signaling pathway (IIS). This sex-biased upregulation IIS triggered by diet-induced stunted mRNA required insulin-like...
Sex differences in whole-body fat storage exist many species. For example, Drosophila females store more than males. Yet, the mechanisms underlying this sex difference remain incompletely understood. Here, we identify a key role for determination gene transformer ( tra ) regulating male-female storage. Normally, functional Tra protein is present only females, where it promotes female sexual development. We show that loss of reduced storage, whereas gain males augmented Tra’s promoting was...
In Drosophila raised in nutrient-rich conditions, female body size is approximately 30% larger than male due to an increased rate of growth and differential weight loss during the larval period. While mechanisms that control this sex difference remain incompletely understood, recent studies suggest insulin/insulin-like factor signaling pathway (IIS) plays a role sex-specific regulation processes influence development. larvae, IIS activity differs between sexes, there evidence ligands. Yet,...
In Drosophila, changes to dietary protein elicit different body size responses between the sexes. Whether these differential effects extend other macronutrients remains unclear. Here, we show that lowering sugar (0S diet) enhanced in male and female larvae. Despite an equivalent phenotypic effect sexes, detected sex-specific signalling pathways, transcription whole-body glycogen protein. males, low-sugar diet augmented insulin/insulin-like growth factor pathway (IIS) activity by increasing...
ABSTRACT Nutrient-dependent body size plasticity differs between the sexes in most species, including mammals. Previous work Drosophila showed that was higher females, yet mechanisms underlying sex difference remain unclear. Here, we discover a protein-rich diet augments females and not males because of female-specific increase activity conserved insulin/insulin-like growth factor signaling pathway (IIS). This increased IIS triggered by diet-induced stunted , required insulin-like peptide 2...
ABSTRACT In Drosophila , changes to dietary protein elicit different body size responses between the sexes. Whether this sex difference in nutrient-dependent regulation extends other nutrients, such as sugar, remains unclear. Here, we show that reducing sugar enhanced male and female larvae. Indeed, largest was found larvae reared a diet without added sugar. Despite equivalent effects of low males females, detected sex-specific insulin/insulin-like growth factor (IIS) target rapamycin (TOR)...
ABSTRACT In Drosophila , female body size is approximately 30% larger than male due to an increased rate of larval growth. While the mechanisms that control this sex difference in remain incompletely understood, recent studies suggest insulin/insulin-like growth factor signaling pathway (IIS) plays a role sex-specific regulation during development. larvae, IIS activity differs between sexes, and there evidence ligands. Yet, we lack knowledge how changes impact each sex, as majority on use...
ABSTRACT Sex differences in whole-body fat storage exist many species. For example, Drosophila females store more than males. Yet, the mechanisms underlying this sex difference remain incompletely understood. Here, we identify a key role for determination gene transformer ( tra ) regulating male-female storage. Normally, functional Tra protein is present only females, where it promotes female sexual development. We show that loss of reduced storage, whereas gain males augmented Tra’s...