A5004923473- Neuropeptides and Animal Physiology
- Advanced Glycation End Products research
- High Altitude and Hypoxia
- Migraine and Headache Studies
- Bacterial Genetics and Biotechnology
- Hearing, Cochlea, Tinnitus, Genetics
- Metabolomics and Mass Spectrometry Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Circadian rhythm and melatonin
- Cancer, Hypoxia, and Metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cholesterol and Lipid Metabolism
- Chronic Kidney Disease and Diabetes
- Genomics and Phylogenetic Studies
- Mitochondrial Function and Pathology
- Neural dynamics and brain function
- Genetics, Aging, and Longevity in Model Organisms
- Liver Disease Diagnosis and Treatment
- Physiological and biochemical adaptations
- RNA and protein synthesis mechanisms
- Bacterial biofilms and quorum sensing
- Artificial Intelligence in Healthcare
- Birth, Development, and Health
- Spaceflight effects on biology
- Cellular transport and secretion
Soochow University
2018-2025
Zhengzhou University
2017-2025
Affiliated Hospital of Qingdao University
2025
Qingdao University
2025
Northwest A&F University
2025
Shenzhen Second People's Hospital
2023
First Affiliated Hospital of Soochow University
2018-2022
Zhengzhou Children's Hospital
2021
Amgen (United States)
2007-2020
Zhongda Hospital Southeast University
2005-2020
Myxococcus xanthus is a Gram-negative bacterium with complex life cycle that includes vegetative swarming and fruiting-body formation. Social (S)-motility (coordinated movement of large cell groups) requires both type IV pili fibrils (extracellular matrix material consisting polysaccharides protein). Little known about the role this extracellular matrix, or fibril material, in pilus-dependent motility. In study, mutants lacking and, therefore, S-motility were found to be hyperpiliated. We...
Gelsolin is an actin filament-severing and -capping protein that has profound effects on filament organization assembly. It activated by Ca2+ inhibited polyphosphoinositides (PPI). We have previously shown PPI inhibit severing the amino-terminal half of gelsolin hypothesized this mediated through inhibition side binding (by domains II-III gelsolin), a requisite first step in severing. In paper, we report subsequent severing, which monomer site located domain I gelsolin, also regulated PPI....
Advanced glycation end products (AGEs) are pathogenic factors of diabetic nephropathy (DN), causing renal damage in various ways. The aim this study is to investigate the ectopic lipid accumulation caused by AGEs human tubular epithelial cell line (HK-2) cells and kidney type 2 rats. In vivo study, diabetes was induced male Sprague–Dawley rats through intraperitoneal injection high-fat/high-sucrose diet low-dose streptozocin (STZ). Two weeks after STZ injection, were randomly divided into...
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in primary headaches. Preclinical evidence suggests that PACAP38 modulates trigeminal nociceptive activity mainly through PAC1 receptors while clinical studies report plasma concentrations of are elevated spontaneous attacks cluster headache and migraine normalize after treatment with sumatriptan. Intravenous infusion induces migraine-like migraineurs cluster-like patients. A rodent-specific receptor...
There is an orderly topographic arrangement of neurones within auditory brainstem nuclei based on sound frequency. Previous immunolabelling studies in the medial nucleus trapezoid body (MNTB) have suggested that there may be gradients voltage-gated currents underlying this tonotopic arrangement. Here, our electrophysiological and results demonstrate organization MNTB a combination medio-lateral low-and high-threshold potassium hyperpolarization-activated cation currents. Our also show...
Aim TM81 (or Tang‐Min‐Ling‐Wan) is a Chinese medicine. Previous studies suggested that this medicine effective for treating type 2 diabetes. This controlled trial evaluated the safety and effectiveness of in treatment diabetic patients. Methods study was large‐scale clinical to evaluate on After 2‐week run‐in period, 480 overweight early‐stage patients [35–65 years old, HbA1c ≥ 7.0%, fasting plasma glucose ( FPG ) 7.0–13.9 mM or h PG > 11.1 , body mass index BMI 24 kg/m ] were enrolled....
ABSTRACT Under starvation conditions, Myxococcus xanthus undergoes a complex developmental process which includes cellular aggregation and sporulation. A transposon insertion mutant (the Tn 5 -Ω280 mutant) with defects in both sporulation was analyzed this study. The found to have disrupted NtrC-like response regulator designated regulatory protein B ( mrpB ). Further sequencing analyses revealed histidine kinase homolog mrpA ) immediately upstream of cyclic AMP receptor protein-like...
The mammalian target-of-rapamycin (mTOR) signaling pathway serves as a major regulator of cell growth, size, and metabolism. In vivo, mTOR exists in two complexes, both which contain the catalytic subunit mTOR, invariable mLST8, complex specific Raptor or Rictor, forming either rapamycin-sensitive mTORC1 rapamycin-insensitive mTORC2, respectively. exact functions Rictor these complexes are still unclear. Here we demonstrate that mTORC1-mediated events require function 26S proteasome....
Diabetic nephropathy (DN) has been associated with the presence of lipid deposition. We hypothesized that disruption intracellular cholesterol feedback may contribute to DN. Diabetes was induced by high fat/sucrose diet and low-dose intraperitoneal injection streptozocin (STZ) in male Sprague-Dawley rats. Then diabetic rats were randomly divided into two groups: untreated group (DM) atorvastatin-treated (DM + AT). found levels serum blood urea nitrogen creatinine, as well 24-hour urine...
Glucose cotransporter (SGLT) 2 suppression provides potent renal protective effect during diabetic kidney disease (DKD). This work aimed to explore how empagliflozin (EMPA, the selective and strong inhibitor of SGLT2) affected lipid deposition among patients undergoing type diabetes mellitus (T2DM), a T2DM mouse model human proximal tubular epithelial (HK-2) cells.This divided subjects as 3 groups: non-diabetic volunteers, treated with metformin those plus EMPA. In an in vivo study, EMPA was...
Background Osteoarthritis (OA) is a common chronic joint disease, but the association between molecular and cellular events pathogenic process of OA remains unclear. Objective The study aimed to identify key in processes immune infiltration synovium provide potential diagnostic therapeutic targets. Methods To differential expression genes function analysis OA, we compared normal samples analyzed protein–protein interaction (PPI). Additionally, was used explore differences cell types, Gene...
Abstract Photoperiod is a pivotal factor in affecting testicular function and spermatogenesis seasonal‐breeding animals. Mitophagy essential for spermatogenesis, but its association with seasonal photoperiods has not been studied extensively. To explore this, we exposed male Brandt's voles ( Lasiopodomys brandtii ) to long‐photoperiod (LP, 16 h/day) short‐photoperiod (SP, 8 conditions from their embryonic stages. Our results indicated that testis weight, volume, relative testes weight were...
ABSTRACT Myxococcus xanthus is a gram-negative soil bacterium that undergoes development under starvation conditions. Our previous study identified new genetic locus, mrp , which required for both fruiting body formation and sporulation. The locus encodes two transcripts: mrpAB consists of histidine kinase an NtrC-like response regulator, mrpC cyclic AMP receptor protein family transcription activator. In this study, we used biochemical analyses to investigate the possible interactions...
The hyperpolarization-activated cation current (I(h)) may influence precise auditory processing by modulating resting membrane potential and cell excitability. We used electrophysiology immunohistochemistry to investigate the properties of I(h) in three brainstem nuclei mice: anteroventral cochlear nucleus (AVCN), medial trapezoid body (MNTB) lateral superior olive (LSO). amplitude varied considerably between these types, with order magnitude LSO > AVCN MNTB. Kinetically, is faster neurons,...