A5045967327- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Phytochemistry and biological activities of Ficus species
- Advances in Cucurbitaceae Research
- Cancer, Hypoxia, and Metabolism
- Hibiscus Plant Research Studies
University of Milano-Bicocca
2022-2024
Glioblastoma is an aggressive brain tumor with high mortality and a median survival of about 15 months. Starting from our previous published compound, MV1035 that inhibited migration invasiveness glioblastoma U87 cells, also exhibited synergic effect in combination the alkylating agent Temozolomide, we identified new active molecules, aim to understand key motifs responsible for activity against DNA repair protein ALKBH2 RNA demethylase ALKBH5. We modified original structure MV1035,...
BackgroundBreast cancer is the most frequent tumor in women. Natural substances represent an important source of innovative therapeutic solutions, eventually integrating or substituting conventional drugs and chemicals. Hibiscus sabdariffa L. a plant Malvaceae family that has raised interest thanks to its anti-inflammatory, antioxidant anticancer effects. In this work, we evaluated antitumoral effects enriched fraction extract (HsEF) two human breast cell lines, MCF-7(ERα +) MDA-MB-231...