A5069624590- Near-Field Optical Microscopy
- Photonic Crystals and Applications
- Advanced MRI Techniques and Applications
- Asymmetric Synthesis and Catalysis
- Inflammatory mediators and NSAID effects
- Synthetic Organic Chemistry Methods
- Transportation Planning and Optimization
- Semiconductor Lasers and Optical Devices
- Transportation and Mobility Innovations
- Photonic and Optical Devices
- Fluorine in Organic Chemistry
- Atomic and Subatomic Physics Research
- Chemical Synthesis and Analysis
- Evacuation and Crowd Dynamics
- Synthesis and Catalytic Reactions
- Enzyme Catalysis and Immobilization
- Synthesis and Reactions of Organic Compounds
- Synthesis of β-Lactam Compounds
- Synthesis and Biological Evaluation
- Optical Coatings and Gratings
- Steroid Chemistry and Biochemistry
- Cancer Treatment and Pharmacology
- Infrastructure Resilience and Vulnerability Analysis
- Estrogen and related hormone effects
- Advanced NMR Techniques and Applications
The University of Tokyo
2000-2024
Institute for Molecular Science
2023-2024
Hokkaido University
1973-2024
Okayama University
2022
Tokyo Institute of Technology
2015
Gifu University
2015
Pioneer (Japan)
2015
Teijin (Japan)
1983-2012
Toshiba (Japan)
1989-2011
Nagoya City University
2000-2011
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic studies on tetrodotoxin and related compounds. IV. Stereospecific total syntheses of DL-tetrodotoxinY. Kishi, T. Fukuyama, M. Aratani, F. Nakatsubo, Goto, S. Inoue, H. Tanino, Sugiura, KakoiCite this: J. Am. Chem. Soc. 1972, 94, 26, 9219–9221Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic studies on tetrodotoxin and related compounds. III. Stereospecific synthesis of an equivalent acetylated tetrodamineY. Kishi, M. Aratani, T. Fukuyama, F. Nakatsubo, Goto, S. Inoue, H. Tanino, Sugiura, KakoiCite this: J. Am. Chem. Soc. 1972, 94, 26, 9217–9219Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December...
A non-contrast-enhanced three-dimensional (3D) magnetic resonance angiography (MRA) technique, which acquires images in a reasonably short scanning time and requires no contrast agent, is developed. An electrocardiographically (ECG) synchronized 3D half-Fourier fast spin-echo (FSE) technique with an appropriate ECG delay for every slice encoding terms was used to examine the thoracic iliac regions 16 healthy volunteers at both 0.5 1.5 T. Prior each fresh blood imaging (FBI) experiment,...
The authors evaluated a nonenhanced magnetic resonance (MR) angiographic technique that allows separation of arteries from veins. In 15 healthy subjects, peripheral MR angiography was performed with readout flow-spoiled gradient pulses in electrocardiography-triggered three-dimensional half-Fourier fast spin-echo imaging. Appropriate were measured and applied the acquisition to differentiate veins vasculature. Subtraction diastolic bright-blood systolic black-blood allowed visualization by...
Abstract BACKGROUND Epidemiological data indicate that intake of one form vitamin E, γ‐tocopherol, may reduce prostate cancer risk, and several in vitro studies have demonstrated γ‐tocopherol can inhibit cell growth. The purpose the present study was to confirm effects on transgenic rat for adenocarcinoma (TRAP) model established our laboratory. METHODS In Experiment 1, heterozygous male TRAP rats 5 weeks age received α‐tocopherol at concentration 50 mg/kg diet, or 100 10 weeks. 2, 3 were...
A novel class of mitogen-activated protein kinase-activated kinase 2 (MAPKAP-K2) inhibitors was discovered through screening a kinase-focused library. homology model MAPKAP-K2 generated and used to guide the initial SAR studies rationalize observed selectivity over CDK2. An X-ray crystal structure compound from active series bound crystalline confirmed predicted binding mode. This has enabled discovery pyrazolo[1,5-a]pyrimidine derivatives showing good in vitro cellular potency as anti-TNF-α...
This article focuses on vulnerability in transportation systems because of large-scale disasters. We proposes an index isolation as a new metric for network analysis. Isolation covers the situation which supporting bases and receiving cannot connect when some links are degraded due to external forces imposed network. is derived solution maximum flow problem one-to-one extended bases. A single set link combinations does not necessarily exist that defines vulnerability, i.e.,...
High intake of phytoestrogens through soybeans and their products is thought to be associated with low incidences prostate and/or breast cancer in Asian countries. Possible chemopreventive effects genistin or daidzin on rat carcinogenesis were therefore investigated. Male F344 rats given 10 biweekly subcutaneous injections 3,2′‐dimethyl‐4‐aminobiphenyl (DMAB) then either the diet at a concentration 0.1% for 40 weeks. Other groups DMAB treated together high dose testosterone propionate (TP)....
The emergence of dockless shared e-scooters as a new form micromobility offers viable solution to specific urban transportation problems, including the first-mile–last-mile issue, parking constraints, and environmental emissions. However, this sharing service faces several challenges in daily operation, particularly related demand volatility, battery recharging, maintenance, regulation, owing their trip physical characteristics. Therefore, study proposed data-driven rebalancing framework for...
Abstract The effects of phenylethyl isothiocyanate (PEITC) on urinary bladder and liver carcinogenesis were analyzed in a rat model. Diets containing 0.1%, 0.05%, or 0.01% PEITC administered for 32 wk to male Fischer 344 rats with without pretreatment an injection diethylnitrosamine (200 mg/kg body wt ip) 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine the drinking water 4 initiation. In initiated groups, administration significantly increased incidences papillary nodular hyperplasia, dysplasia,...
A novel MR angiography (MRA) method, swap phase encode extended data (SPEED), was developed. Two one-shot images with the phase-encode directions swapped were collected within a single breath-hold period and processed maximum intensity projection (MIP) to obtain an image. In this study, long echo train two-dimensional rapid acquisition relaxation enhancement (RARE) sequence half-Fourier (half-RARE) used pulmonary MRA images. The MIP image obtained using SPEED technique presented promising...
ABSTRACT When salted surimi paste of chum salmon was incubated at 20–60°C, a marked loss the breaking strength heat‐induced gel occurred simultaneously with breakdown myosin heavy chain, but this effectively suppressed by addition cysteine protease inhibitors or bovine plasma powder. In presence inhibitor, gels were formed relatively low temperatures showing highest incubations 50 and 60°C. Chum showed no evidence suwari chain cross‐linking.
Using section-select and phase-encoding gradients, the authors obtained phosphorus chemical shift images of human head limb. Phosphorus spectra were acquired from planar sections divided into voxels as small 7 cm3 in calf muscle 27 brain, with total examination times, including setup proton locator imaging, roughly 1 hour. Both spin-echo free induction decay (FID) methods employed; FID gave superior results. Signal-to-noise ratios for beta-adenosine triphosphate phosphocreatine resonances...
Phenylethyl isothiocyanate (PEITC), generally thought to be a chemopreventive agent for various kinds of genotoxic carcinogens, has been found induce rat urinary bladder carcinomas in our laboratory. To cast light on the underlying mechanisms, reversibility urothelial proliferative lesions and frequencies H-ras p53 mutations induced tumors were investigated. F344 male rats given diet containing 0.1% PEITC 48 weeks then killed, or 32 returned normal without supplement 1, 3, 7 days 16 before...
Heat-assisted magnetic recording (HAMR) is a promising technology for achieving more than 1 Tbit/inch2 density. A near-field transducer (NFT), which forms small light spot on medium, necessary in HAMR. However, the heat generated by NFT would melt itself. To solve this problem, authors have proposed novel device, metal nano-antenna attached to semiconductor ring resonator. In paper, relationship between various design parameters of device and was investigated through numerical simulation...
The three-component coupling process allows a single-pot entry to protected 7-hydroxy-PGE1 derivatives, leading variety of new PGs functionalized or unsaturated at C-7. enone and dienone derivatives exhibit potent inhibitory activity on L1210 tumor cell growth in vitro.
Novel 7-thiaprostaglandin E1 derivatives and congeners were synthesized by a stepwise three-component coupling process, which involves the introduction of α-side chains (thiols) β-side (organocopper reagents) into (R)-4-tert-butyldimethylsilyloxy-2-cyclopentenone. Several acid also prepared either enzymatic or chemical methods. The stereochemistry these products was assigned on basis results with chiral protected cyclopentenones ω-side chains. Some found to exhibit more potent platelet...