A5003840634- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Bone health and treatments
- Ubiquitin and proteasome pathways
- Radiation Therapy and Dosimetry
- RNA modifications and cancer
- Cardiac Structural Anomalies and Repair
- HIV-related health complications and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Estrogen and related hormone effects
- Cerebrovascular and Carotid Artery Diseases
- Medical Imaging and Pathology Studies
- Cardiovascular Disease and Adiposity
- Lung Cancer Treatments and Mutations
- DNA Repair Mechanisms
- Effects of Radiation Exposure
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
University of Pretoria
2018-2024
Steve Biko Hospital
2018-2023
Abstract Background A remarkable therapeutic efficacy has been demonstrated with 225 Ac-prostate-specific membrane antigen (PSMA)-617 in heavily pre-treated metastatic castration-resistant prostate cancer (mCRPC) patients. We report our experience Ac-PSMA-617 therapy chemotherapy-naïve patients advanced carcinoma. Methods Seventeen were selected for treatment 2-month intervals, initial activity of 8 MBq, then de-escalation to 7 6 MBq or 4 cases good response. In one patient, was escalated 13...
Metastatic prostate carcinoma overexpresses prostate-specific membrane antigen (PSMA), making this a suitable target for radioligand therapy of the disease. Here we report on our experience with series 73 castration-resistant patients treated <sup>225</sup>Ac-PSMA-617, identifying variables predictive overall survival (OS) and progression-free (PFS) after <sup>225</sup>Ac-PSMA-617 treatment. <b>Methods:</b><sup>225</sup>Ac-PSMA-617 was administered to who had metastatic exhausted available...
225Ac-PSMA-617, targeting the prostate-specific membrane antigen (PSMA), which is overexpressed on prostate cancer cells, has shown a remarkable therapeutic efficacy in heavily pretreated patients with metastatic castration-resistant carcinoma (mCRPC). Here, we report treatment outcome and survival using this novel modality series of 53 mCRPC directly after their androgen deprivation (ADT). Methods:225Ac-PSMA-617 was administered to such patients. 68Ga-PSMA PET/CT obtained at baseline,...
Hypoxia leads to changes in tumor microenvironment (upregulated CAFs) with resultant aggressiveness. A key factor the physiological response hypoxia is hypoxia-inducible factor-1alpha (HIF-1α). [68Ga]Ga-FAPI PET imaging has been demonstrated various cancer types. We hypothesized that may be used as an indirect tracer for mapping by correlating image findings pathological analysis of HIF-1α expression. The PET/CT scans women cervix were reviewed and maximum mean standardized uptake value...
Hypoxia in cervical cancer has been associated with a poor prognosis. Over the years 68Ga labelled nitroimidazoles have studied and shown improved kinetics. We present our initial experience of hypoxia Positron Emission Tomography (PET) imaging 68Ga-Nitroimidazole derivative correlation 18F-FDG PET/CT immunohistochemistry. Twenty women underwent both imaging. Dual-point was performed for PET. Immunohistochemical analysis inducible factor-1α (HIF-1α). documented SUVmax, SUVmean primary...
People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) Gallium-68 pentixafor [68Ga]Ga-pentixafor PET/CT for quantification arterial in PLHIV. We prospectively recruited (HIV)-infected patients...
Introduction: Cervical cancer lesions, like most solid tumors, grow large, and outgrow their blood supply which leads to hypoxia. Hypoxia has been shown upregulate the presence functions of associated fibroblasts (CAFs) results in increased aggressiveness. inducible factor-1α (HIF-1α) is a well-studied marker PET imaging gynecological cancers with 68Ga-FAPI documented. We aimed utilize as surrogate tracer hypoxia we correlated findings immunohistochemical analysis HIF-1α expression.