A5102762119- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Knee injuries and reconstruction techniques
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Silk-based biomaterials and applications
- Ovarian cancer diagnosis and treatment
- Proteoglycans and glycosaminoglycans research
- Gestational Diabetes Research and Management
- Tissue Engineering and Regenerative Medicine
- Endometrial and Cervical Cancer Treatments
- 3D Printing in Biomedical Research
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Ferroptosis and cancer prognosis
- Gallbladder and Bile Duct Disorders
- Atherosclerosis and Cardiovascular Diseases
- Tendon Structure and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
Hangzhou Medical College
2023-2025
Zhejiang Provincial People's Hospital
2022-2025
Second Affiliated Hospital of Guangzhou Medical University
2024-2025
Guangzhou Medical University
2024-2025
National University of Singapore
2013-2024
Bengbu Medical College
2024
Inner Mongolia People's Hospital
2023-2024
Nanyang Technological University
2014-2022
National University Health System
2018-2020
Harbin Medical University
2017-2020
Atherosclerosis is a chronic and multifactorial inflammatory disease closely associated with cardiovascular cerebrovascular diseases. circRNAs can act as competing endogenous RNAs to mRNAs function in various However, there little known about the of atherosclerosis. In this study, three rabbits case group were fed high-fat diet induce atherosclerosis another normal diet. To explore biological functions atherosclerosis, we analyzed circRNA, miRNA mRNA expression profiles using RNA-seq. Many...
Secretome derived from mesenchymal stem cells (MSCs) have profound effects on tissue regeneration, which could become the basis of future MSCs therapies. Hypoxia, as physiologic environment MSCs, has great potential to enhance paracrine therapeutic effect. In our study, secretome preconditioned in normoxia and hypoxia was compared through both vitro functional assays an vivo rat osteochondral defect model. Specifically, effect total EVs were that soluble factors characterize predominant...
Abstract Photothermal therapy (PTT) is a new treatment modality for tumors. However, the efficient delivery of photothermal agents into tumors remains difficult, especially in hypoxic tumor regions. In this study, an approach to deliver melanin, natural agent, using genetically engineered bacteria image‐guided and immune developed. An Escherichia coli MG1655 transformed with recombinant plasmid harboring tyrosinase gene produce melanin nanoparticles. Melanin‐producing (MG1655‐M) are...
Background Regenerative medicine researches have shown that mesenchymal stem cells (MSCs) may be an effective treatment method for premature ovarian insufficiency (POI). However, the efficacy of MSCs is still limited.
Abstract Although most in vitro studies indicate that transforming growth factor β3 (TGF‐β3) immobilized scaffold is suitable for cartilage tissue engineering, vivo of implanting chondral defect repair are still lacking. This study to evaluate the potentials TGF‐β3 poly‐(lactic‐ co ‐glycolic acid)‐gelatin/chondroitin sulfate/hyaluronic acid (PLGA‐GCH) hybrid regeneration. The was fabricated by incorporating GCH micro‐sponges into PLGA frameworks and then crosslinked with mimic natural...
A microfluidic cell sorting based selective culture expansion method for mesenchymal stem improves yield and chondrogenic potential.
Current surgical techniques for osteochondral injuries in young active patients are inadequate clinically. Novel strategies tissue engineering continuously explored this area. Despite numerous animal studies that have shown encouraging results, very few large-scale clinical trials been done to address area of interest. To facilitate the eventual translation from rabbit human subjects, we performed a study using bone marrow-derived mesenchymal stem cell (BMSC)–oligo[poly(ethylene glycol)...
Different forms of biomaterials, including microspheres, sponges, hydrogels and nanofibres have been broadly used in cartilage regeneration; however, effects internal structures biomaterials on chondrogenesis mesenchymal stem cells (MSCs) remain largely unexplored. Here we investigated the effect physical microenvironments sponges chondrogenic differentiation MSCs. MSCs, cultured these two scaffold systems, were induced with TGF-β3 chondrogeneic medium was evaluated compared after three...
Oxidative stress injury is an important pathological factor of premature ovarian failure (POF). Salidroside, extracted from the Chinese herb-
<h3>Importance</h3> An automated, accurate method is needed for unbiased assessment quantifying accrual of joint space narrowing and erosions on radiographic images the hands wrists, feet clinical trials, monitoring damage over time, assisting rheumatologists with treatment decisions. Such a has potential to be directly integrated into electronic health records. <h3>Objectives</h3> To design implement an international crowdsourcing competition catalyze development machine learning methods...
To investigate the role of ADIPOQ gene in gestational diabetes mellitus (GDM). We genotyped single nucleotide polymorphisms (SNPs) rs266729 and rs1501299 within a cohort 1157 pregnant women north Chinese Han ethnicity. This comprised 560 diagnosed with GDM 597 who exhibited normal oral glucose tolerance test at 24-28 weeks' gestation. All participants were recruited from Department Obstetrics Gynecology Second Affiliated Hospital Harbin Medical University. Additionally, we used conventional...
Mesenchymal stromal cells (MSCs) are promising candidates for cartilage repair therapy due to their self-renewal, chondrogenic, and immunomodulatory capacities. It is widely recognized that a shift from fetal bovine serum (FBS)-containing medium toward fully chemically defined serum-free (SF) would be necessary clinical applications of MSCs eliminate issues such as xeno-contamination batch-to-batch variation. However, there notable gap in the literature regarding evaluation chondrogenic...
Abstract Background This study aimed to examine the performance of four risk malignancy index (RMI) in discriminating borderline ovarian tumors (BOTs) and benign masses daily clinical practice. Methods A total 162 women with BOTs 379 diagnosed at Second Affiliated Hospital Harbin Medical University from January 2012 December 2016 were enrolled this retrospective study. Also, we classified these patients into serous tumor (SBOT) mucinous (MBOT) subgroup. Preoperative ultrasound findings,...
To investigate the associations of GCKR and ADIPOQ variants with risk gestational diabetes mellitus (GDM) in Chinese women.GCKR rs1260326, rs266729, rs1501299 were selected genotyped 519 GDM patients 498 controls. Candidate SNPs using multiplex polymerase chain reaction (PCR) combined next-generation sequencing methods, association these was analyzed.We found that rs1260326 significantly associated an increased allele model, codominant model (CC vs. TT), dominant recessive genotypic...
Atherosclerosis is one of the most common clinical cardiovascular disorders.Accumulating evidence indicates that lncRNAs exert critical functions in atherosclerosis; however, their functional roles and regulatory mechanisms remain unclear.In this study, we induced atherosclerotic plaques three rabbit carotid arteries through an atherogenic diet balloon injury; age-matched rabbits were fed normal chow served as controls.We thoroughly investigated RNA (mRNA, lncRNA miRNA) expression profiles...
Chondrogenic differentiation of human mesenchymal stem cells (MSCs) in three-dimensional hydrogel holds promise as a method for repairing injured articular cartilage. Given MSC plasticity (its potential to mature into alternative lineages), nondestructive monitoring is critical the optimization chondrogenic conditions and evaluation final product. However, conventional validation/assessments process (i.e., quantitative reverse transcription polymerase chain reaction [qRT-PCR] histology) are...