A5045181951- Pharmacogenetics and Drug Metabolism
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Genomics, phytochemicals, and oxidative stress
- Inflammatory mediators and NSAID effects
- Analytical Chemistry and Chromatography
- Drug-Induced Hepatotoxicity and Protection
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Hormonal Regulation and Hypertension
- Semiconductor materials and devices
- Gastric Cancer Management and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Advancements in Semiconductor Devices and Circuit Design
- Hormonal and reproductive studies
- Metastasis and carcinoma case studies
- Multiple and Secondary Primary Cancers
- Low-power high-performance VLSI design
- Alcohol Consumption and Health Effects
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
Kwansei Gakuin University
2015-2025
NTT WEST Osaka Hospital
2011
Osaka City University
1998-2010
Renesas Electronics (Japan)
2004-2009
Osaka Medical Center for Cancer and Cardiovascular Diseases
1988-2008
Renesas Electronics (United States)
2006-2008
Osaka University
1981-2007
Mitsubishi Electric (Japan)
2004
Okayama University
2001
Kanazawa Medical University
2001
In the sub-100-nm CMOS generation, a large local Vth variability degrades 6T-SRAM cell stability, so that we have to consider this as well global achieve high-yield SRAM products. Therefore, need employ some assist circuits expand operating margin. We propose variability-tolerant layout and new circuit techniques improve both read write margins in presence of variability. By applying these 0.494-mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
The purpose of the study was to elucidate human intestinal cytochrome P450 isoform(s) involved in metabolism an antihistamine, ebastine, having two major pathways hydroxylation and N-dealkylation. ebastine dealkylase microsomes CYP3A4, based on inhibition studies with antibodies against CYP1A, CYP2A, CYP2C, CYP2D, CYP2E, CYP3A isoforms their selective inhibitors. However, hydroxylase could not be identified. We then examined inhibitory effects anti-CYP4F antibody 17-octadecynoic acid,...
The metabolism of lidocaine by human hepatic microsomes and purified cytochrome P-450s, P-450NF (P450IIIA4), P-450MP (a P450IIC form) P-450PA (P450IA2) was examined their compared with that rat P-450s. Human produced monoethylglycinexylidide (MEGX) 3-hydroxylidocaine (3-OH-LID) from lidocaine. In a reconstituted system dilauroylphosphatidylcholine, efficiently MEGX. not efficient in N-deethylation (formation MEGX) but 3-OH-LID. did produce Lidocaine activity enhanced modified phospholipid...
Apigenin, a plant-derived flavone, is potent inhibitor of cell proliferation and angiogenesis, but the mechanisms leading to pathological anti-angiogenic effects apigenin are still unclear. In this study, we found that inhibited hypoxia-induced expression vascular endothelial growth factor (VEGF) mRNA in human umbilical artery cells. Apigenin also suppressed erythropoietin mRNA, which typical hypoxia-inducible gene, via degradation 1 (HIF-1) alpha. We investigated effect on interaction...
Sonographic and histologic correlation was studied in 20 cases with a combined total of 23 resected lesions hepatocellular carcinoma. All were examined by sonography within 1 week before surgery. Tumor sonograms classified as hypoechoic, complex, or hyperechoic on the basis difference echogenicity between lesion surrounding liver parenchyma. Fourteen excised pathologic specimens after surgery fixed-position sectional sonographic technique that permitted detailed comparison findings. Each...
Cytochromes P450IVA1 and IVA3 display 72% amino acid sequence similarity are expressed in livers of rats treated with the hypolipidemic drug clofibrate. The catalytic activities IVA1 were examined by cDNA-directed expression using vaccinia virus. cDNA-expressed had relative Mrs 51,500 52,000, respectively, on SDS-polyacrylamide gels. Both enzymes displayed reduced, CO-bound absorption spectra lambda max 452.5 nm. hydroxylated lauric at omega omega-1 positions equivalent omega/omega-1 ratios...
To determine the orthology of sterol 14-demethylase (P45014DM), only known P450 enzyme distributed widely in eukaryotes with a conserved metabolic role, full-length amino acid sequences rat and human P45014DMs were determined from cloned cDNA sequences, compared those corresponding fungal proteins (CYP51). The identity value between given pairs ranged 93% (human/rat) to 39% (human or rat/Saccharomyces cerevisiae;). All formed single cluster phylogenetic tree constructed representative...
Bisphenol A [2,2-bis-(4-hydroxyphenyl) propane; BPA] is a versatile industrial material for plastic products, but increasingly being recognized as pervasive pollutant well. Accumulating evidence indicates that the environmental contaminant BPA one of endocrine-disrupting chemicals potentially can adversely affect humans well wildlife. To define molecular aspects action, we first investigated molecules with which it physically interacts. High BPA-binding activity was detected in P2 membrane...
Hypoxia induces the expression of nuclear factor kappa B (NF-kappa-B). NF-kappa-B functions by forming dimers from five main subunits: p65 (RelA), RelB, p52, p50, and c-Rel. In classical pathway, activity is regulated degradation-inducing I kinase (IKK). IKK composed an α/β isomer essential modulator NEMO (γ) subunits in which may be major pathway for signaling. present study, we focused on factor-inhibiting HIF-1 (FIH-1) Prolyl hydroxylase domain enzyme (PHD), have been identified as oxygen...
To evaluate the risk of exposure to so-called non-genotoxic chemicals and elucidate mechanisms underlying their promoting activity on rat liver carcinogenesis formation 8-hydroxy-2′-deoxyguanosine (8-OHdG), cytochrome P-450 (P-450) hydroxyl radicals induction, DNA repair alteration cellular proliferation apoptosis in were investigated during 2 weeks phenobarbital (PB) administration at a dose 0.05%. Significant increase radical levels by day 4 PB accompanied accumulation 8-OHdG nucleus...