A5102781079- Osteoarthritis Treatment and Mechanisms
- RNA Research and Splicing
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA and protein synthesis mechanisms
- melanin and skin pigmentation
- Cancer-related molecular mechanisms research
- Protein Tyrosine Phosphatases
- Cell Adhesion Molecules Research
- Dermatologic Treatments and Research
- Cancer, Lipids, and Metabolism
- Abdominal Trauma and Injuries
- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Anomalies and Fetal Surgery
- Hair Growth and Disorders
- Temporomandibular Joint Disorders
- Chemokine receptors and signaling
Xuzhou Medical College
2024-2025
Nanjing University
2021-2025
Nanjing Drum Tower Hospital
2024
Fujian Medical University
2019
Zhangzhou Municipal Hospital of Fujian Province
2005
Abstract Hyaline cartilage fibrosis is typically considered an end-stage pathology of osteoarthritis (OA), which results in changes to the extracellular matrix. However, mechanism behind this largely unclear. Here, we found that RNA helicase DDX5 was dramatically downregulated during progression OA. deficiency increased phenotype by upregulating COL1 expression and downregulating COL2 expression. In addition, loss aggravated degradation inducing production cartilage-degrading enzymes....
ABSTRACT Background Temporomandibular joint osteoarthritis (TMJOA) is a prevalent musculoskeletal condition characterized by pain, cartilage degeneration, and subchondral bone loss. Objective This study sought to identify specific targets for the treatment of TMJOA. Method Through high‐throughput RNA‐seq analysis in condylar chondrocytes (NC vs. MS), we discovered that DDX5 was downregulated closely negatively related progression Similarly, found injured patients as well condyles UAC‐induced...
Protein tyrosine kinases regulate osteoarthritis (OA) progression by activating a series of signal transduction pathways. However, the roles protein phosphatases (PTPs) in OA remain obscure. This study was undertaken to identify specific PTPs involved and investigate their underlying mechanisms.The expression 107 PTP genes human cartilage analyzed based on single-cell sequencing data set. The enzyme activity SH2 domain-containing phosphatase 2 (SHP-2) detected primary chondrocytes after...
Hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is rarely seen in clinical practice, and its treatment strategies prognosis are still a subject of debate. To ascertain the characteristics for HCC BDTT, 49 patients BDTT were studied out 763 consecutive who underwent surgical from July 2004 to May 2018. The those reviewed analyzed retrospectively. Of patients, 25 radical resection, 7 thrombectomy through choledochotomy, 17 palliative internal external drainage. Results...
<title>Abstract</title> Hyaline cartilage fibrosis is one of the important reasons for poor prognosis advanced osteoarthritis (OA), and main factor leading to joint stiffness deformity. However, mechanism hyaline remains largely unclear. Here we found that DDX5, most members DEAD-box RNA helicase family, was dramatically downregulated in degenerated articular aged mice, destabilization medial meniscus murine model as well patients with OA. Chondrocyte-specific deletion Ddx5 led much severe...