A5013403618- Phytochemicals and Antioxidant Activities
- Cancer, Hypoxia, and Metabolism
- Chalcogenide Semiconductor Thin Films
- Melanoma and MAPK Pathways
- Oxidative Organic Chemistry Reactions
- Industrial Vision Systems and Defect Detection
- Signaling Pathways in Disease
- Children's Physical and Motor Development
- Neuroblastoma Research and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Building materials and conservation
- Nanocluster Synthesis and Applications
- ATP Synthase and ATPases Research
- Advanced Sensor and Energy Harvesting Materials
- Quantum Dots Synthesis And Properties
- Radical Photochemical Reactions
- Recycling and Waste Management Techniques
- Bee Products Chemical Analysis
- Archaeology and ancient environmental studies
- Horticultural and Viticultural Research
- Nuts composition and effects
- Conducting polymers and applications
- Essential Oils and Antimicrobial Activity
- Insect and Pesticide Research
- Concrete and Cement Materials Research
University of Genoa
2021-2024
Cancer stem cells (CSCs) are a limited cell population inside tumor bulk characterized by high levels of glutathione (GSH), the most important antioxidant thiol which cysteine is limiting amino acid for GSH biosynthesis. In fact, CSCs over-express xCT, cystine transporter stabilized on membrane through interaction with CD44, stemness marker whose expression modulated protein kinase Cα (PKCα). Since many chemotherapeutic drugs, such as Etoposide, exert their cytotoxic action increasing...
Herein, we report for the first time an experimental design-based approach to develop water-based graphite conductive ink containing enzymes and redox mediators obtain fully printed wearable biosensors lactate glucose monitoring. The design encompasses both electrochemical parameters, such as electroactive area electron transfer rate constant, rheological including elastic (G′) viscous (G″) moduli where G″/G′ is expressed tanδ. Notably, electrodes exhibited AEA of 3.95 ± 0.31 cm2 a roughness...
Despite unifloral honeys from Sardinia, Italy, being appreciated worldwide for their peculiar organoleptic features, elemental signature has only partly been investigated. Hence, the principal aim of this study was to measure concentration trace and toxic elements (i.e., Ag, As, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Hg, Li, Mn, Mo, Ni, Pb, Sb, Sn, Sr, Te, Tl, V, Zn) in four produced Sardinia. For purpose, an original ICP-MS method developed, fully validated, applied on asphodel, eucalyptus,...
Malignant melanoma is the most lethal form of skin cancer which shows BRAF mutation in 50% patients. In this context, identification BRAFV600E led to development specific inhibitors like PLX4032. Nevertheless, although its initial success, clinical efficacy reduced after six-months therapy leading relapse due onset drug resistance. Therefore, investigating mechanisms underlying PLX4032 resistance fundamental improve efficacy. several models have been developed, but discrepancy between vitro...
Chestnut processing has increasingly grown in recent years. All the processes involved chestnut supply chain are characterized by production of high levels by-products that cause several environmental and disposal issues. The Castanea spp. fruit is related to a number episperm. This underutilized agricultural by-product may be evaluated as good resource for extraction health-promoting natural molecules, such phenolics. preliminary study aimed develop optimize, using multivariate statistical...
Tennis is an open-skill sport in which the athletes have a short period of time to elaborate all information coming from surrounding environment and produce motor answer based on them. The aim this study was divided two hypotheses: 1) assess if belonging certain category, athlete, or non-athlete, older younger, can affect development reaction children; 2) protocol visual training (VT) 6 weeks could improve performance field young tennis players using FitLight Trainer (Medical Graphics,...
Pollution caused by plastics and, in particular, microplastics has become a source of environmental concern for Society. Their ubiquity, with millions tons plastic debris spilled both land and sea, requires efficient technological improvements the ways residues are collected, handled, characterized recycled. For reliable decision-making, dependable chemical information is essential to assess nature found environment their fate. In this work an method identify polymeric composition...
Calcined clays and calcium carbonates can be used to reduce clinker factor in blended cements, offering significant economic environmental benefits. Limestone calcined clay cements (LC3) combine them as supplementary cementitious materials (SCMs) for delivering a sustainable alternative conventional Ordinary Portland Cement products, with envisioned applications construction rehabilitation of historical buildings. This study reports chemometric approach the development LC3 mortars, targeting...
Neuroblastoma (NB) accounts for about 8–10% of pediatric cancers, and the main causes death are presence metastases acquisition chemoresistance. Metastatic NB is characterized by MYCN amplification that correlates with changes in expression miRNAs, which small non-coding RNA sequences, playing a crucial role development In present study, miRNA was analyzed two human MYCN-amplified cell lines, one sensitive (HTLA-230) resistant to Etoposide (ER-HTLA), microarray RT-qPCR techniques. These...
Basil-based semi-finished products, which are mainly used as an intermediate to produce the typical pesto sauce, prepared and exported all over world. Color is a fundamental organoleptic requirement for acceptability of these products by manufacturers sauce. Some alternative formulations, adjust industrial recipe both changing preservative agent (ascorbic acid, citric or mixture both) introducing preliminary thermic treatment (blast chilling), were evaluated. In this work, fast...
In this work, a detailed study of Monte Arci obsidian sub-sources using the increasingly accessible technique pXRF is presented based upon large dataset 68 geological samples, for development X-ray fluorescence-based analytical standardless procedure. addition, non-conventional (for provenance study) direct application multivariate analysis on XRF spectra (continuous variables), rather than absolute concentrations or intensity ratios (discrete variables) proposed. Results from different...
The emissive material, consisting of blue-emitting CdSe colloidal nanoplatelets, and the organic charge injection layers were optimized using design experiments, to produce a solution-processed blue light-emitting diode.
Pollution caused by plastics and, in particular, microplastics has become a source of environmental concern for Society. Its ubiquity, with millions tons plastic debris spilled both land and sea, requires efficient technological improvements the ways residues are collected, handled, characterized recycled. For reliable decision-making, dependable chemical information is essential to assess nature found environment their fate. In this work an method identify polymeric composition microplastic...
Abstract In this paper we report a [2 + 2] cycloaddition reaction between ketenes and benzils, characterized by an unusual double photochemical activation triggered visible light. Employment of flow system optimization conditions through Design Experiments resulted in moderate to good yields the corresponding β-lactones. A thorough computational analysis allowed elucidate mechanism justify observed diastereoselectivity. The was also successfully tested with mixed showing complete...
Nowadays, archaeological disquisitions should be frequently based on archaeometry with analytical tools used not as mere black boxes but through a critical analysis of all possible sources error. Once the objective has been defined, e.g., in terms provenance, function, technology questions, an protocol available instruments designed to build non-destructive, time- and cost-effective routine. In this work, assessment X-ray fluorescence-based standardless procedure determine intra-source...