A5052960857- HIV Research and Treatment
- MicroRNA in disease regulation
- Cannabis and Cannabinoid Research
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Face and Expression Recognition
- Tryptophan and brain disorders
- Advanced Steganography and Watermarking Techniques
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- HIV/AIDS Research and Interventions
- Spam and Phishing Detection
- Software Engineering Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Medical Image Segmentation Techniques
- Image Retrieval and Classification Techniques
- Chaos-based Image/Signal Encryption
- Software System Performance and Reliability
- Gut microbiota and health
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- Mobile Ad Hoc Networks
Texas Biomedical Research Institute
2020-2025
Saveetha University
2024
Xavier Institute of Management and Entrepreneurship
2024
Jawaharlal Nehru Technological University, Hyderabad
2013-2023
Chaitanya Bharathi Institute of Technology
2022
Tulane University
2010-2019
Queen's University Belfast
2019
George Washington University
2013-2018
Andhra University
2017
Jawaharlal Nehru Technological University Anantapur
2017
Although the advent of combination anti-retroviral therapy (cART) has transformed HIV into a manageable chronic disease, an estimated 30-50% people living with (PLWH) exhibit cognitive and motor deficits collectively known as HIV-associated neurocognitive disorders (HAND). A key driver HAND neuropathology is neuroinflammation, where proinflammatory mediators produced by activated microglia macrophages are thought to inflict neuronal injury loss. Moreover, dysregulation microbiota-gut-brain...
Recreational and medical use of cannabis among human immunodeficiency virus (HIV)-infected individuals has increased in recent years. In simian (SIV)-infected macaques, chronic administration Δ9-tetrahydrocannabinol (Δ9-THC) inhibited viral replication intestinal inflammation slowed disease progression. Persistent gastrointestinal disease/inflammation been proposed to facilitate microbial translocation systemic immune activation promote Cannabinoids including Δ9-THC attenuated mouse colitis...
The composition of the gut microbiome reflects overall health status host. In this study, stool samples representing microbiomes from 6 gluten-sensitive (GS) captive juvenile rhesus macaques were compared with those healthy, age- and diet-matched peers. A total 48 both groups studied using V4 16S rRNA gene DNA analysis. Samples GS further characterized based on type diet administered: conventional monkey chow, i.e., wheat gluten-containing (GD), gluten-free (GFD), barley gluten-derived...
Extracellular particles (EPs) are produced/secreted by cells from all domains of life and present in body fluids, brain, gut. EPs consist extracellular vesicles (EVs) made up exosomes, microvesicles, other membranous vesicles; condensates (ECs) that non-membranous carriers lipid-protein-nucleic acid aggregates. The purity EVs|ECs, which ultimately depends on the isolation method used to obtain them is critical, particularly EVs|ECs gastrointestinal (GI) tract colonized a huge number enteric...
The internet of things (IoT) has become popular as a means connecting people and in order to gather share data through embedded sensors. Consequently, robust multipath routing techniques are required guarantee network lifetime enhance energy efficiency. main challenge secure the longevity IoT networks is load balancing issue priority-based, congested-free communication infrastructure. This research intends propose IoT. steps carried out are: (i) routing, (ii) traffic scheduling. In route...
Cannabis use is frequent in HIV-infected individuals for its appetite stimulation and anti-inflammatory effects. To identify the underlying molecular mechanisms associated with these effects, we simultaneously profiled micro-RNA (miRNA) mRNA expression colon of chronically simian immunodeficiency virus (SIV)-infected rhesus macaques administered either vehicle (VEH/SIV; n=9) or Δ9- tetrahydrocannabinol (Δ9-THC; THC/SIV; n=8). Proinflammatory miR-130a, miR-222 miR-29b,...
Although patients with human immunodeficiency virus type 1 infection who are receiving antiretroviral therapy and those long-term, nonprogressive (LTNPs) usually have undetectable viremia, persists in tissue reservoirs throughout infection. However, the distribution magnitude of viral persistence replication tissues has not been adequately examined. Here, we used simian (SIV) macaque model to quantify compare RNA DNA small (jejunum) large (colon) intestine LTNPs. In LTNPs chronic infection,...
Our studies have demonstrated that chronic Δ9-tetrahydrocannabinol (THC) administration results in a generalized attenuation of viral load and tissue inflammation simian immunodeficiency virus (SIV)-infected male rhesus macaques. Gut-associated lymphoid is an important site for HIV replication can impact disease progression. We used systems approach to examine the duodenal immune environment 4- 6-year-old monkeys inoculated intravenously with SIVMAC251 after 17 months THC (0.18–0.32 mg/kg,...
Intestinal epithelial barrier dysfunction, a hallmark of HIV/SIV infection, persists despite viral suppression by combination antiretroviral therapy (cART). Emerging evidence suggests critical role for long noncoding RNAs (lncRNAs) in maintaining homeostasis. We simultaneously profiled lncRNA/mRNA expression exclusively colonic epithelium (CE) SIV-infected rhesus macaques (RMs) administered vehicle (VEH) or Δ-9-tetrahydrocannabinol (THC). Relative to controls, fewer lncRNAs were up-...
Persistent gastrointestinal inflammation, a hallmark of progressive HIV/SIV infection, causes disruption the epithelial barrier, microbial translocation, and generalized immune activation/inflammation driving AIDS progression. Apart from protein regulators, recent studies strongly suggest critical roles for microRNAs (miRNAs) in regulating managing certain aspects inflammatory process. To examine their immunoregulatory role, we profiled miRNA expression colon 12 chronic SIV-infected 4...
As robots continue to create long-term maps, the amount of information that they need handle increases over time. In terms place recognition, this implies number images being considered may increase until exceeding computational resources robot. paper we consider a scenario where, given multiple independent large possibly from different cities or locations, robot must effectively and in real time decide whether it can localize itself one those known maps. Since be handled by such system is...