This study focused on the synthesis and characterization of hydrazide ligands their respective Pd(II) complexes used high throughput screening to determine α-glucosidase carbonic anhydrase II enzyme inhibition activities. The physical, analytical (elemental analyses for C, H, N Pd) spectral (FT-IR, 1H NMR, 13C EI-mass) techniques utilized during revealed formation square planar, neutral 1:2 Pd(II)-hydrazide with general formula [PdL2Cl2]. In these complexes, are monodentate; terminal...

Oxovanadium(IV) -derived antifungals have been prepared by condensing equimolar amounts of vanadyl sulfate with hydrazides. All the synthesized ligands and their metal complexes were characterized IR, UV–Visible micro analytical data. These compounds screened for antifungal activity against Aspergillus flavus (A. flavus), Trichophyton longifusus (T. longifusus), Candida albicans (C. albicans), Microsporum canis (M. canis), Fusarium solani (F. solani) glaberata glaberata) fungal strains....

Spectroscopic, enzyme-inhibition, and free-radical scavenging properties of a series hydrazide ligands their vanadium(IV) complexes have been investigated. Analytical spectral data indicate the presence dimeric unit with two oxovanadium(IV) ions (VO2+) coordinated along water molecules. All are stable in solid state, but exhibit varying degrees stability solution. Binding coordinating solvent such as DMSO is indicated at 6th position vanadium followed by conversion to monomeric intermediate...

Vanadium is known to exhibit several bioactivities and shows potential as a pharmaceutical drug. The current studies were conducted with the goal of synthesizing new generation oxovanadium(IV) complexes, investigating their effects on cancer cell proliferation immunomodulatory properties, predicting possible structure activity relationships. elucidation structures synthesized complexes was achieved using elemental analysis, conductivity measurements, magnetic property IR electronic...

Acid hydrazides are vital chemical entities due to their biological activities. Upon complexation with certain metal ions, activities known be positively enhanced. The present work describes the synthesis of Cr(III)-hydrazide complexes, and structural, spectroscopic antioxidant properties reveal chemistry biochemistry. Physical (magnetic moment, conductivity measurements), analytical (C, H, N Cr analysis) spectral (EI-Mass, FTIR) techniques used for characterization synthesized compounds....

Abstract Fluoroquinolones are extensively used in clinical applications as a crucial class of antibacterial medicine and have shown high potential for the treatment several other diseases. This study is based on synthesis, structure elucidation biological evaluation various fluoroquinolone ( enoxacin ) analogues with electrophilic substitution aromatic amine moiety central nucleus by benzyl halides. The synthesized derivatives were characterized basis different chemical physical measurements...

In the title compound, C(7)H(8)N(2)O(2), mean planes of benzene ring and planar hydrazide group are inclined at 25.75 (6)° with respect to each other. The structure is stabilized by inter-molecular N-H⋯O O-H⋯N hydrogen bonds.

The title compound, C(8)H(10)N(2)O(2), is stabilized by three inter-molecular hydrogen bonds of the N-H⋯O and N-H⋯N types. Two intra-molecular inter-actions C-H⋯O types are also observed.

The title compound was synthesized and its crystal structure determined by X-ray diffraction analysis. is monoclinic, space group P21/a with Z = 4. unit-cell dimensions are a 12.287(2)Å, b 3.8287(5)Å, c 16.0936(19)Å, β 97.409° V 750.77(19)Å3. R value 0.0313 for 1223 observed reflections. Intermolecular hydrogen bonds of the type N-H…O N-H…N were in structure.

Antioxidant, anti-inflammatory, antiviral and antitumoral activities among others are essential characteristics in the development of novel therapeutic compounds. Acid hydrazides can form complexation with certain metal ions that positively enhance these biological characteristics.Five new complexes uranium hydrazide ligands were synthesized at room temperature.The characterization was done by spectroscopic methods (ESI-Mass, IR, 1H-NMR, 13CNMR), CHN analysis conductivity measurements. Metal...

In the structure of title compound, C(7)H(7)IN(2)O, hydrazide group is inclined at 13.3 (3)° with respect to benzene ring. The stabilized by inter-molecular N-H⋯N and N-H⋯O hydrogen bonds involving group, resulting in six- ten-membered rings R(2) (2)(6) (2)(10) graph-set notations, respectively.

The title mol-ecule, C(8)H(7)N(3)O, is almost planar, with a maximum deviation of 0.0232 (2) Å from the least-squares plane. Z conformation C=N double bond stabilized by an intra-molecular N-H⋯O hydrogen bond. In crystal, adjacent mol-ecules are linked inter-molecular N-H⋯N and bonds, forming zigzag sheets parallel to c axis; further π-π inter-actions [centroid-centroid distance = 3.7390 (10) Å].

Abstract Diabetes mellitus (DM) is a well‐known progressive endocrine disorder and has become serious worldwide medical concern stimulating the search for new therapeutic agents. In current study, nitrogen oxygen based twenty oxamide derivatives were synthesized their potential to inhibit α ‐glucosidase enzyme was studied. Oxamides using oxalyl chloride corresponding aniline in 1 : 2 ratio basic medium. Structures of these compounds determined by mass spectrometry, various spectroscopic...

Thermodynamic parameters for the reduction of ferrioxamine E as calculated from redox potentials determined at four different temperatures were found to be DeltaH( not equal)=7.1+/-3.4 kJ mol(-1) and DeltaS( equal)=-146 J K(-1). The negative entropy value is large, because decrease in charge metal center an increase its ionic radius force structure complex become less rigid resemble desferrisiderophore. hydrophilic groups system are now (relatively more) available solvent interaction. Thus,...

The title compound, C(7)H(9)N(3)O, crystallizes with two independent mol-ecules per asymmetric unit. structure is stabilized by four distinct inter-molecular N-H⋯O hydrogen bonds. Four intra-molecular inter-actions of the N-H⋯N and C-H⋯O types are also observed.

Abstract Metal complexes have pivotal applications in catalysis, photochemistry, and biological systems. Due to their unique chemical properties, metal occupy a coveted place the field of drug design. The present study includes synthesis symmetrical oxamides ( O1 – O11 ) copper C1 C11 that potential inhibit α‐glucosidase lipoxygenase enzymes. To elucidate structures these compounds, spectroscopic investigations including mass spectrometry, 1 H‐NMR spectroscopy, UV‐Visible spectroscopy IR...

ABSTRACT. Ti(III) and (IV) hydrazide complexes were synthesized, characterized, screened for their tyrosinase lipoxygenase inhibitory cytotoxic activities. The geometry of is tentatively assigned as octahedral. Magnetic moments found around 1.7 B.M. electronic spectral transition in the range 495-518 nm. Evaluation Ti(IV) activities revealed varying inhibition potential. Hydrazide ligands inactive against tyrosinase, while significant activity was observed (LOX). Good to moderate by both...

The title compound, C(15)H(12)N(4)O(2), contains two substituted benzohydrazide and indole rings linked via a C=N double bond. dihedral angle between the benzene ring system is 11.38 (10)°. mol-ecular structure stabilized by an intra-molecular N-H⋯O hydrogen bond, forming six-membered ring. crystal consolidated inter-molecular C-H⋯O inter-actions, which result in sheets.

The title compound, C(8)H(10)N(2)O(2), crystallizes as two independent mol-ecules linked by N-H⋯N and N-H⋯O hydrogen bonds into a linear chain running along the axis of monoclinic unit cell. intra- inter-molecular are described two-ring R(2) (2)(10) motif. six-membered R(1) (1)(6) rings formed intra-molecular inter-actions almost planar (r.m.s. deviations 0.06 0.08 Å). In one mol-ecule, aromatic hydrogen-bonded oriented at 4.8 (2)°, whereas in other mol-ecule these 6.1 (4)°.

The title compound, C(8)H(10)N(2)O(2), crystallizes with two independent mol-ecules in an asymmetric unit. structure is stabilized by nine inter-molecular N-H⋯N, N-H⋯O and C-H⋯O hydrogen bonds.

A combination of biologically active ligand and metal in one molecule may increase the activity reduce toxicity.In this study, synthesis characterization platinum(IV) complexes with bioactive hydrazide ligands are discussed.Elemental analysis, conductivity measurements, spectroscopic studies were used to elucidate structure complexes.Our study suggests that coordinate Pt(IV) a bidentate fashion. The have octahedral geometry ratio 1:2. Hydrazide coordinated central by oxygen carbonyl group...

In the title compound, C(7)H(8)N(2)O(4), dihedral angle between aromatic ring and hydrazide grouping is 21.34 (7)°. crystal, mol-ecules are linked into a three-dimensional network by O-H⋯O, O-H⋯N N-H⋯O hydrogen bonds.