A5067806634- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Bee Products Chemical Analysis
- X-ray Diffraction in Crystallography
- Pharmacological Effects of Natural Compounds
- Crystallization and Solubility Studies
- Phytochemistry and Bioactivity Studies
- Cancer therapeutics and mechanisms
- Bioactive Natural Diterpenoids Research
- Insect and Pesticide Research
- Phytochemicals and Antioxidant Activities
- Metal complexes synthesis and properties
- Healthcare and Venom Research
- Cholinesterase and Neurodegenerative Diseases
- Bioactive natural compounds
- Phytochemistry and biological activity of medicinal plants
- Phytochemical compounds biological activities
- Synthesis and Characterization of Heterocyclic Compounds
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Steroid Chemistry and Biochemistry
University of Tabuk
2016-2025
University of Karachi
2012-2021
International Center for Chemical and Biological Sciences
2012-2021
United States Postal Service
2021
National University of Malaysia
2014-2015
National Centre for Research
2015
King Saud University
2013
Universiti Sains Malaysia
2013
Université de Yaoundé I
2008
University of Douala
2008
Recent evidence suggests an important role for natural honey in modulating immune response. To identify active components responsible, this study investigated the immunomodulatory properties of glycoproteins and glycopeptides fractionated from Ziziphus honey. Honey proteins/peptides were by size exclusion chromatography into five peaks with molecular masses range 2–450 kDa. The proteins exhibited potent, concentration-dependent inhibition reactive oxygen species production zymosan-activated...
Abstract Thrombin, hyperglycemia and reactive oxygen species (ROS) have been discovered to play a pivotal role in the pathogenesis of cardiovascular disease (CVD). The aim study was evaluate direct effect bovine thrombin (BTh) on ROS production by human neutrophils rodent macrophages investigate honey BTh‐induced from phagocytes. Professional phagocytes, i.e. macrophages, were stimulated BTh measured luminol/lucigenin enhanced chemiluminescence (CL) assays. In another experiment effects...
Phytochemical investigation on Myrtus communis Linn. afforded myrtucommuacetalone (1) with an unprecedented carbon skeleton and a new phloroglucinol-type compound, myrtucommulone M (2), along four known constituents 3–6. Their structures were established by extensive analyses of NMR mass spectral data as well single-crystal X-ray diffraction studies. These evaluated for their ability to modulate the immune response, based effects various components system. Compounds 1 5 exhibited significant...
Context: Tagetes patula Linn. (Asteraceae) (French Marigold) flowers are used by local practitioners for cancer treatment; however, it lacks scientific justification.
Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus-castus, was found to be potent immunomodulatory and cytotoxic compound. The activity tested in vitro for chemiluminescence, chemotaxis, T-cell proliferation cytotoxicity. (1) exhibited significant inhibitory effect on monocyte oxidative burst dose dependent manner. It have suppressive chemotaxic action at higher concentrations fMLP (10(-8) m) stimulated neutrophils. also showed PHA (PMBC).
The present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types and were obtained. characterized by different physicochemical, spectroscopic, elemental analysis. Results suggest that interacts metals as a monoanionic bidentate ligand. These also tested for their antibacterial activity against eleven (11) microorganisms, results compared parent drug. Moreover all metal ability to scavenge reactive oxygen species where Mn II Cu exhibited...
Lung cancer is one of the leading causes death worldwide. We investigated molecular mechanism antiproliferation potential Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. inhibited proliferation, arrested G0/G1 phase, stimulated release as well suppressed p53 Bcl-2 in a dose-dependent manner. proposed that line due to cycle arrest, stimulation cytokines downregulation genes.
BACKGROUND: Ziziphus jujuba belongs to family Rhamnaceae widely distributed in subtropical and tropical countries. It is used traditionally for several pharmacological purposes including anti-inflammation, antidiarrhoeal antibacterial, as well tonic sometimes hypnotic (sedative).AIM: To determine the vivo antidiarrhoeal, antibacterial anti-inflammatory activities of Z. fruit ethanolic extract.METHOD: The was macerated extracted by 95% (v/v) ethanol. activity evaluated using castor oil...
Immunosuppressive effects of the standardized extract Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats Menaga Ilangkovan, Ibrahim Jantan, Mohamed Ahmed Mesaik, Syed Nasir Abbas BukhariDrug and Herbal Research Center, Faculty Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaAbstract: (family: Euphorbiaceae) is immense interest due to its wide spectrum biological activities. In present study, 80% ethanol P. was investigated for modulatory activity various...
During this study, one new coumarin; 7-O-β-D-glucopyranoside-2H-1-benzopyran-2-one (1) and three quinoline alkaloids; 3-hydroxy, 2, 6-trimethyl–3, 4, 5, 6-tetrahydro-2H-pyrano[3,2-c] 5-one (2), ribalinine (3) methyl isoplatydesmine (4) were isolated from the aerial parts of Skimmia laureola their structures established by spectroscopic studies. Compounds 2-4 found to be linear mixed type inhibitors acetylcholinesterase (Ki = 110.0, 30.0 μM, respectively). 2 3 also butyrylcholinesterase,...
Two new β-indoloquinazoline alkaloids, orisuaveoline A (1) and B (2), two furoquinoline quinosuaveoline (5) (6), 12 known compounds were isolated from Oricia suaveolens. The structures of the deduced by spectroscopic studies. absolute configuration nkolbisine (4) was also determined. Compounds 2, 3, 6−8, 10, 14 evaluated for oxidative burst inhibitory activity in a chemoluminescence assay cytotoxicity against A549 lung carcinoma cells.