A5028607024- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Neurological Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Diabetes Management and Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Protein purification and stability
- Muscle and Compartmental Disorders
- Biochemical effects in animals
- Venous Thromboembolism Diagnosis and Management
- Systemic Sclerosis and Related Diseases
- Acute Kidney Injury Research
- Cardiac Imaging and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Leptospirosis research and findings
- Erythrocyte Function and Pathophysiology
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
Sechenov University
2020-2023
Lomonosov Moscow State University
2019-2023
Moscow State University
2020-2023
Leeds Teaching Hospitals NHS Trust
2022
University of Leeds
2022
S. M. Kirov Military Medical Academy
2022
Pirogov Russian National Research Medical University
2022
Chelyabinsk State University
2020
Nikiforov Russian Center of Emergency and Radiation Medicine
2020
Russian New University
2020
Aim To evaluate mortality and risk factors for death in patients with COVID-19 who required admission to intensive care units (ICU) respiratory support Russia Material methods In a retrospective study, we collected medical records of the consecutive ICU submitted by local hospitals across Federal Center at Sechenov University (Moscow) betweenMarch 16 May 3, 2020 All have completed their hospital stay (death or recovery) Diagnosis SARS-CoV-2 pneumonia was established both polymerase chain...
In a retrospective study, we evaluated factors associated with the early development of septic shock in patients severe COVID-19.We collected medical records intensive care unit submitted by local COVID-19 hospitals across Russia to Federal Center for Critical Care at Sechenov First Moscow State Medical University (Sechenov University). Septic crticially ill requiring mechanical ventilation was defined as need vasopressors maintain blood pressure.We studied 1078 who were admitted units...
Treatment of patients with long-term persistent symptoms after COVID-19 is an urgent problem for clinicians around the world. One most significant manifestations post-COVID-19 syndrome organizing pneumonia that usually treat corticosteroids. The paper presents a clinical case typical course in patient without previous lung disease. Risk factors, diagnostic methods and treatment options this group are also discuss.
Leishmaniasis is a vector-born parasitic disease characterized by predominant cutaneous or visceral involvement with fever, hepatosplenomegaly and anemia. has relatively high prevalence in tropical subtropical areas. Several sporadic mostly imported cases are detected Russian Federation. Nevertheless, some local incidents noted southern areas (Crimea, Dagestan). Lack of epidemiological alertness hampers confirmation diagnosis may lead to incorrect treatment. The article summarizes current...
This non-randomized controlled study aimed to assess the efficacy of tofacitinib in reducing risk invasive mechanical ventilation or death patients with COVID-19. Patients COVID-19 associated reduced oxygen saturation, increased C-reactive protein (≥50 mg/L), and/or persisting fever were recruited. Tofacitinib was administered addition standard care therapy. Study outcomes evaluated separately groups saturation at rest ≤93% and >93%. Hazard ratios (HR) 95% confidence intervals (CI)...
<b>Background:</b> Multiple factors, such as male gender and diabetes mellitus(DM) are known predictors of severe coronavirus disease(COVID-19). Nevertheless, it is not always possible to predict the disease outcome in a particular patient. Elevated serum creatine kinase(CK) level COVID-19 patients correlates with higher mortality. The objective our trial was evaluate association CK levels high-risk groups. <b>Methods:</b> 229 without signs myocardial damage or rhabdomyolysis were divided...
Abstract Background and aim Many genetic studies have been reported about the association between APOE, APOC3 gene polymorphisms response to statin therapy in myocardial infarction, but results remain controversial. The of this study was investigate SNP rs7412 (APOE), rs2854117 (APOC3), rs2854116 (APOC3) lipid-lowering effect atorvastatin rosuvastatin patients with infarction. Methods Polymorphism genes APOE (rs7412), (rs2854117 rs2854116) determened. Lipid profile determined on admission...
Aim. To determine the incidence and risk factors of acute kidney injury (AKI) in Russian cohort patients with COVID-19. Materials methods. We included 315 patients, who were hospitalized COVID-19 from October 2020 till February 2021. The diagnosis was established on basis positive SARS-CoV-2 swab test and/or typical radiologic findings CT scans. Results. AKI complicated clinical course 92 (29.21%) cases. independent female sex, underline chronic disease highest level C-reactive protein...
Recently, data have been published on the leading role of endothelial dysfunction in development severe COVID-19, including acute renal failure (AKI) and poor prognosis this group patients. Aim. To define angiopoetin-1(Ang-1) as a marker AKI patients, hospitalized with COVID-19. Materials methods. 76 patients confirmed coronavirus infection were included study. was diagnosed according to KDIGO 2012 criteria 44 (group 1), 32 without sings kidney disfunction 2. Beside standard clinical...
Acute alcohol intoxication in rats with alloxan diabetes is accompanied by the increase of urea and uric acid decrease free fatty acids serum. In liver experimental animals activity glutamate dehydrogenase, AMP deaminase, tyrosine transaminase was found.
Renewable conditions of hypoglycemia are a frequent complication in the treatment diabetes mellitus, determine clinic pancreatic insulinomas, observed diseases kidneys, liver, gastrointestinal tract and alcoholism, leading to development posthypoglycemic encephalopathy. At same time, single, even severe, insulin coma is accompanied by reversible metabolic changes brain.
 Therefore, pathological features metabolism nervous tissue, which result repeated hypoglycemia, particular possible...
Hypoglycemic coma was induced with 40 U of insulin per kg body weight. The animals experiencing 7 hypoglycemic comas at 2-day intervals and killed during the last were found to have elevated serum levels free fatty acids, urea, uric acid; hepatic glycogen remained normal. In liver, activities aspartate aminotransferase (EC 2.6.1.1), alanine 2.6.1.2), glutaminase 3.5.1.2), glutamate dehydrogenase 1.4.1.3), succinate 1.3.99.1), lactate 1.1.1.27) enhanced rate generation increased when glucose...