A5101478304- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Cell Adhesion Molecules Research
- Computational Drug Discovery Methods
- Metal and Thin Film Mechanics
- Amino Acid Enzymes and Metabolism
- Cellular Mechanics and Interactions
- Microstructure and mechanical properties
- Receptor Mechanisms and Signaling
- Drug Transport and Resistance Mechanisms
- Phytochemistry and Biological Activities
- Chemical Synthesis and Analysis
- Synthesis and biological activity
- Biochemical and Molecular Research
- Analytical Methods in Pharmaceuticals
- Force Microscopy Techniques and Applications
- HIV/AIDS drug development and treatment
- Phytochemistry and biological activity of medicinal plants
- Cancer therapeutics and mechanisms
- Skin and Cellular Biology Research
- Fungal Plant Pathogen Control
- Boron and Carbon Nanomaterials Research
University of New Orleans
2024
Thomas Jefferson University
2022-2024
Tulane University
2024
Bar-Ilan University
2018-2022
Indian Institute of Science Bangalore
2014-2019
Dr. Reddy's Laboratories (United States)
2010
University of Minnesota
2004-2006
Jadavpur University
2001-2004
The urea cycle is strongly implicated in the pathogenesis of Alzheimer's disease (AD). Arginase-I (ARGI) accumulation at sites amyloid-beta (Aβ) deposition associated with L-arginine deprivation and neurodegeneration. An interaction between arginase II (ARGII) mTOR-ribosomal protein S6 kinase β-1 (S6K1) pathways promotes inflammation oxidative stress. In this study, we treated triple-transgenic (3×Tg) mice exhibiting increased S6K1 activity wild-type (WT) L-norvaline, which inhibits both...
Growing evidence highlights the role of arginase activity in manifestation Alzheimer's disease (AD). Upregulation was shown to contribute neurodegeneration. Regulation appears be a promising approach for interfering with pathogenesis AD. Therefore, enzyme represents novel therapeutic target. In this study, we administered an inhibitor, L-norvaline (250 mg/L), 2.5 months triple-transgenic model (3×Tg-AD) harboring PS1M146V, APPSwe, and tauP301L transgenes. Then, neuroprotective effects were...
According to epidemiological research, breast cancer is the fifth leading cause of cancer-related deaths worldwide and more frequently diagnosed than lung cancer. There growing awareness adverse effects radiation immunotherapy on several organs, as well variety symptoms that can recur. Several natural compounds are being employed adjuncts or in therapy part an alternative treatment regimen currently investigated worldwide. Additionally, a number undergoing various phases clinical testing....
Abstract Phosphorylation of hundreds protein extracellular domains is mediated by two kinase families, yet the significance these kinases underexplored. Here, we find that presynaptic release tyrosine directed-ectokinase, Vertebrate Lonesome Kinase (VLK/Pkdcc), necessary and sufficient for direct interaction between EphB2 GluN1 at synapses, phosphorylation ectodomain EphB2, injury-induced pain. Pkdcc an essential gene in nervous system, VLK found synaptic vesicles, released from neurons a...
Hepatocellular carcinoma (HCC) represents the fifth most common cancer worldwide and third cause of cancer-related mortality. Hepatitis C virus (HCV) is leading chronic hepatitis, which often results in liver fibrosis, cirrhosis, eventually HCC. HCV risk factor for HCC western countries leads to a more aggressive invasive disease with poorer patient survival rates. However, mechanism by induces metastatic spread tumor cells through regulation invadopodia, key features cancer, still unknown....
Abstract The etiology of Autism Spectrum Disorders (ASD) includes a strong genetic component and complicated environmental component. Recent evidence indicates that maternal diabetes, including gestational is associated with an increased prevalence ASD. While previous studies have looked into possible roles for diabetes in neurodevelopment, there are few how no diabetic or metabolic phenotype, may affect neurodevelopment. In this study, we specifically induced mice, followed by behavioral...
Adult neurogenesis is a complex physiological process, which plays central role in maintaining cognitive functions, and consists of progenitor cell proliferation, newborn migration, maturation. susceptible to alterations under various pathological conditions. A substantial decay has been documented Alzheimer's disease (AD) patients animal AD models; however, several treatment strategies can halt any further decline even induce neurogenesis. Our previous results indicated potential effect...
DNA processing protein A (DprA) plays a crucial role in the process of natural transformation. This is accomplished through binding and subsequent protection incoming foreign during internalization. DprA along with Single stranded (SsbA) acts as an accessory factor for RecA mediated strand exchange. H. pylori (HpDprA) divided into N-terminal domain C- terminal domain. In present study, individual domains HpDprA have been characterized their ability to bind single (ssDNA) double (dsDNA)....
Abstract The methanol extract of A. webbiana Lindl was evaluated for its effect on a cough model induced by sulphur dioxide gas in mice. When administered orally it exhibited significant antitussive activity compared with the control dose dependent manner. that codeine phosphate, prototype agent. leaf (400 and 600 mg/kg) showed maximum inhibition frequency 71.69% 78.67%, respectively, when group comparable to phosphate. Copyright © 2003 John Wiley & Sons, Ltd.
We develop an approach that combines the power of nonlinear dynamics with evolution equations for mobile and immobile dislocation densities force to explain fluctuations in nanoindentation experiments. The model includes nucleation, multiplication, propagation thresholds dislocations, other well known transformation mechanisms. predicts all generic features such as Hertzian elastic branch followed by several drops decreasing magnitudes, residual plasticity after unloading. stress...
Repeated cocaine exposure causes dendritic spine loss in the orbitofrontal cortex, which might contribute to poor cortical function following drug exposure. One challenge, however, has been verifying links between neuronal structural plasticity and behavior, if any. Here we report that self-administration triggers of spines on excitatory neurons cortex male female mice (as reported rats). To understand functional consequences, locally ablated β1-integrins, cell adhesion receptors adhere...