Paxlovid was granted an Emergency Use Authorization for the treatment of mild to moderate coronavirus disease 2019 (COVID-19), based on interim analysis Evaluation Protease Inhibition COVID-19 in High-Risk Patients (EPIC-HR) trial. effectiveness needs be assessed a noncontrolled setting. In this study we used population-based real-world data evaluate Paxlovid.The database largest healthcare provider Israel identify all adults aged 18 years or older with first-ever positive test severe acute...

Combined oral contraceptives are a common method of contraception, but they carry risk venous and arterial thrombosis. We assessed whether use drospirenone was associated with an increase in thrombotic relative to third-generation combined contraceptives.Using computerized records the largest health care provider Israel, we identified all women aged 12 50 years for whom had been dispensed between Jan. 1, 2002, Dec. 31, 2008. followed cohort until 2009. used Poisson regression models estimate...

To identify risk factors for the development of statin-associated diabetes mellitus (DM).The study was conducted in two phases. Phase one involved high-throughput silico processing a large amount biomedical data to DM. In phase two, most prominent factor identified confirmed an observational cohort at Clalit, largest health care organization Israel. Time-dependent Poisson regression multivariable models were performed assess rate ratios (RRs) with 95% CIs DM occurrence.A total 39,263 statin...

ABSTRACT Background: β2‐adrenoreceptors have recently been identified as regulators of the α‐synuclein gene, which is implicated in pathogenesis Parkinson's disease. Objective: The objectives this study were to assess association between use β2‐agonists and β‐antagonists risk developing PD. Methods: We conducted a nested case‐control cohort 1,762,164 adults without diagnosis They on January, 1, 2004, from electronic medical records largest health care provider Israel. Participants followed...

Concomitant use of direct oral anticoagulants (DOACs) and medications with inhibition/induction effect on P-gp/CYP3A might increase risk bleeding/treatment failure, respectively. We designed a nested case-control study within Clalit cohort patients atrial fibrillation (AF) venous thromboembolism, new users DOAC (January 1, 2010 to August 24, 2020). Propensity scores were constructed from demographic/clinical characteristics, at entry. Each case of: (i) serious bleeding event; (ii)...

Molnupiravir was granted emergency use authorization for the treatment of mild to moderate coronavirus disease 2019 (COVID-19). In this study, we used population-based real-world data evaluate effectiveness molnupiravir.The database largest healthcare provider in Israel identify all adults with first-ever positive test severe acute respiratory syndrome 2 (SARS-CoV-2) performed community during January-February 2022, who were at high risk COVID-19, and had no contraindications molnupiravir...

Tixagevimab and cilgavimab, a combined monoclonal antibody (Evusheld), was granted emergency use authorization for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) preexposure prophylaxis in individuals with immunocompromising conditions. In this study we used population-based real-world data to evaluate the effectiveness of Evusheld immunocompromised patients.Using computerized database largest healthcare provider Israel, identified all adult patients who were eligible receive...

An excess risk of Bell's palsy has been suggested after mRNA vaccines. We examined the association between BNT162b2 COVID-19 vaccine and palsy.

Background: Radioactive iodine (131I) is in widespread use for the treatment of hyperthyroidism. Data on long-term safety outcome are limited and conflicting. The objectives this study were to evaluate association radioiodine hyperthyroidism with overall cancer specific types. Methods: This a historical cohort study, using Clalit health care database. Participants all adults new diagnosis 2002–2015, newly treated 131I, or thionamides (propylthiouracil/thiamazole), excluding patients previous...

Purpose: Bisphosphonates are used for treatment or prevention of osteoporosis and bone metastases. The use oral bisphosphonates was suggested to be associated with reduced risk developing breast cancer, their positive influence on cancer survival only demonstrated third-generation bisphosphonates. We studied the association after diagnosis overall survival.Experimental Design: A nested case-control analysis performed using data from population-based Breast Cancer in Northern Israel Study...

OBJECTIVE To examine the association of diabetes and glycated hemoglobin (HbA1c) with risk intracerebral hemorrhage (ICH) in a large population-based cohort. RESEARCH DESIGN AND METHODS The computerized database largest health care provider Israel was used to identify adult members aged 40 years or older alive at 1 January 2010 (297,486 1,167,585 without diabetes). cohort followed until 31 December 2017 for incidence ICH. Multivariable Cox proportional hazards regression models, adjusted...

Existing data regarding occurrence of Guillain-Barré syndrome (GBS) after coronavirus disease 2019 (COVID-19) infection and vaccination are inconclusive. We aimed to assess the association between GBS both severe acute respiratory 2 (SARS-CoV-2) COVID-19 vaccine.

Background An association between atrial fibrillation (AF) and risk of cancer has been suggested in several studies, including prospective cohort studies. However, the magnitude temporal nature this remain unclear. Methods Data from two large population-based case-control Molecular Epidemiology Colorectal Cancer (MECC, n = 8,383) Breast Northern Israel Study (BCINIS, 11,608), were used to better understand temporality a possible diagnosis AF events before after diagnosis. A study approach...

To examine the association between statin exposure in a dose-dependent manner and intracerebral hemorrhage (ICH) large nationwide study.The computerized database of largest health care provider Israel was used to identify diagnosed ICH among new users statins, who started treatment 2005 2010. We assessed dose-response relationship using average atorvastatin equivalent daily dose (AAEDD). Multivariable Cox proportional hazard regression models, adjusted for baseline disease risk score, were...

The impact of cancer therapies on cardiac disease in the general adult survivor population is largely unknown. Our objective was to evaluate which tyrosine kinase-targeting drugs are associated with greater risk for new-onset heart failure (HF). A nested case–control analysis conducted within a cohort 27 992 patients Clalit Health Services, newly treated kinase-targeting, and/or chemotherapeutic drug, malignant disease, between 1 January 2005 and 31 December 2012. Each new case HF matched up...

Existing molecular knowledge base of cardiovascular diseases is rudimentary because lack specific attribution to cell type and function. The aim this study was investigate cell-specific remodeling in human atrial ventricular myocytes associated with ischemic cardiomyopathy. Our strategy combines two technological innovations, laser-capture microdissection identified cardiac cells selected anatomical regions the heart splice microarray a narrow catalog functionally most important genes...