A5100763305- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanofabrication and Lithography Techniques
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Advanced Surface Polishing Techniques
- Electrowetting and Microfluidic Technologies
- Advanced Sensor and Energy Harvesting Materials
- Advanced machining processes and optimization
- Cancer Cells and Metastasis
- Manufacturing Process and Optimization
- Electrochemical sensors and biosensors
- Hydraulic flow and structures
- Organic Light-Emitting Diodes Research
- Advanced MEMS and NEMS Technologies
- Molecular Communication and Nanonetworks
- Analytical Chemistry and Sensors
- Fluid Dynamics and Vibration Analysis
- Quantum-Dot Cellular Automata
- Conducting polymers and applications
- Additive Manufacturing and 3D Printing Technologies
- Heat Transfer and Optimization
- Advancements in Photolithography Techniques
- Neuroscience and Neural Engineering
- Heat Transfer and Boiling Studies
Gachon University
2022
Kyungnam University
2013-2019
Louisiana State University
2007-2012
Louisiana State University Agricultural Center
2011
Korea University
2010
The present study demonstrates a flexible gas-diffusion barrier film, containing an SiO(2)/Al(2)O(3) nanolaminate on plastic substrate. Highly uniform and conformal coatings can be made by alternating the exposure of polyethersulfone surface to vapors SiO(2) Al(2)O(3), at nanoscale thickness cycles via RF-magnetron sputtering deposition. calcium degradation test indicates that 24 10/10 nm inorganic bilayer, top-coated UV-cured resin, greatly enhance performance, with permeation rate 3.79 ×...
A high throughput, multi-well (96) polymerase chain reaction (PCR) platform, based on a continuous flow (CF) mode of operation, was developed. Each CFPCR device confined to footprint 8 × mm2, matching the well standard micro-titer plate. While several devices have been demonstrated, this is first example high-throughput thermal reactor configuration. Verification feasibility carried out at each stage development from manufacturing demonstrating sample amplification. The were fabricated by...
Recently, thermoplastic polymers have become popular materials for microfluidic chips due to their easy fabrication and low cost. A polymer based device can be formed in various techniques such as laser machining, injection molding, hot embossing. new bonding process presented this paper uses a 2.5% (w/w) polymethyl methacrylate (PMMA) solution an adhesive layer bond dissimilar polymers-PMMA polycarbonate (PC)-to enclose the PMMA channels with PC. This technique has been successfully...
A novel thermoplastic fusion bonding method using a pressure-assisted boiling point (PABP) control system was developed to apply precise temperatures and pressures during bonding. Hot embossed polymethyl methacrylate (PMMA) components containing microchannels were sealed the PABP system. Very low aspect ratio structures (AR = 1/100, 10 μm in depth 1000 width) successfully without collapse or deformation. The integrity strength of bonds on PMMA devices evaluated leakage rupture tests; no...
Abstract Long‐term and highly sensitive electrophysiological signal detection is the primary issue for wearable health monitoring. The critical issues of pre‐gelled wet electrodes as conventional approaches are limited conductivity low adhesivity owing to dependence moisture concentration. Along this line, paper presents a biocompatible, mechanically robust, water degradable, intrinsically conductive organic composite dry film electrode based on poly(3,4‐ethylenedioxythiophene) polystyrene...
In the development of functional lab-on-a-chip (LOC), there is a need to produce reliable and high pressure connection between capillary tubes microfluidic devices for carrying fluids. The current technologies still have limitations in achieving ideal interconnection since they are bulky, expensive or complicated. this paper, novel connector-free technique using an interference fit mechanism introduced world-to-chip interconnection. proposed has considerable potential replacing tools due...
Thermoplastic fusion bonding is widely used to seal polymer microfluidic devices and optimal protocol required obtain a successful bonding, strong force without channel deformation. Besides, UV modification of the PMMA (poly-methyl methacrylate) commonly for chemical or biological application before process. However, study thermal modified was not reported yet. Unlike pristine PMMA, parameters were 103˚C, 71 kPa, 35 minutes. A very low aspect ratio micro (AR=1:100, 20 μm depth 2000 width)...
Demand has increased for the double‐sided moulding of microfluidic devices a series biochemical analyses. Accurate alignment mould inserts is critical aspect to transfer doubled‐sided patterns on top and bottom surfaces moulded part. A method was studied hot embossing polymer devices. An designed using kinematic constraints, set three locating pins. To validate method, two brass with fluidic reservoirs were used prototype The constraints align each other machine. misalignment features parts...
The effect of inlet mixer geometries on the two-phase flow patterns in square micro-channel with <TEX>$600{\times}600{\mu}m$</TEX> was investigated experimentally this paper. 4 different configurations based Y, Impacting, and two T types (gas liquid inlets were switched) used. test fluids nitrogen water. gas superficial velocities 0.01~10 m/s 0.1~100 m/s, respectively. Several distinctive patterns, namely, annular, slug-annular, slug, slug-bubbly, bubbly, churn could be seen. pattern maps...
A method of collecting and delivering single or precise numbers cells to assess the feasibility capturing very rare circulating tumor for human breast cancer diagnosis monitoring was developed. PMMA device assembled with minimal assembly variation using passive alignment. Thermoplastic fusion bonding optimized yield deformation microfluidic channel. UV modification an anti-epithelial cell adhesion molecule (anti-EpCAM) functionalization process were used generate capture surfaces maximized...
A method for thermoplastic fusion bonding was introduced using a commercial pressure cooker as thermal chamber to apply heat and polymer bonding. The controlled by simply modifying the regulator weight, which decided boiling point of water in chamber. In this experiment, Poly-Methyl Methacrylate (PMMA) thermally bonded proposed technique. For PMMA bonding, 52 grams weight well matched 26.2 kPa pressure. corresponding temperature 105.5℃, glass transitional PMMA. system demonstrated between...
Minimizing misalignments during the interconnection of microfluidic modules is extremely critical to develop a fully integrated device. Misalignments arising chip-to-chip or world-to-chip interconnections can be greatly detrimental efficient functioning devices. To address this problem, we have performed numerical simulations investigate effect in three types methods: (i) end-to-end (ii) channel overlap when chips are stacked on top each other, and (iii) tube-in-reservoir misalignment...
A cost effective alignment and positioning system was developed for double-sided hot embossing processes using kinematic principles. Alignment tooling located transferred the top mold insert location to proper complementary performed. The samples were checked accuracy consistency. Adjustments made sampling repeated measured. Results showed can improve locating of in relation a repeatable manner.
Circulating tumor cells (CTCs) may become a new foundation for early stage cancer diagnosis requiring minimal patient effort [1]. This approach can overcome the limitations of current diagnostic technologies, including computer-aided tomography (CT), magnetic resonance imaging (MRI), X-ray mammography, and ultrasound (UR) which detect only highly calcified tumors at relatively high cost. Several studies have demonstrated CTC capture using microfluidic devices to identify presence human...
Circulating tumor cells (CTCs) were captured at high flow rates with a recovery rate using small footprint disposable polymer micro device. A new concept of target cell capture was introduced to break through the barriers limiting current approaches. Several potential designs parametrically simulated computational fluid dynamics (CFD) achieve best performance. The device (HFRD) fabricated in polymethyl methacrylate (PMMA) based on simulation results. Antibodies (anti-EpCAM) immobilized PMMA...
Movable weir is a major system used to manage water level in river secure drinking water, agricultural and industrial water. It critical safely construct operate movable weir, any environmental circumstances. In this study, we performed an unsteady flow analysis, on the with overflow depth. The continuity equation, constant density incompressible Navier-Stokes were for analysis. CFD results applied structural evaluate safety of weir. According analysis results, has secured sufficient safety.