A5083499825- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Neurological Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Quinazolinone synthesis and applications
- Chemical synthesis and pharmacological studies
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects of Natural Compounds
- Polymer Synthesis and Characterization
- Fluorine in Organic Chemistry
- Traditional Chinese Medicine Analysis
- Analytical Chemistry and Chromatography
- Cholesterol and Lipid Metabolism
- Sepsis Diagnosis and Treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reactions and Isotopes
- Phytochemicals and Antioxidant Activities
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cytokine Signaling Pathways and Interactions
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Blood Coagulation and Thrombosis Mechanisms
- Human Health and Disease
- Inflammasome and immune disorders
- Healthcare Systems and Public Health
- Synthesis and Biological Evaluation
Volgograd State Medical University
2017-2024
Ministry of Health of the Russian Federation
2017-2024
Hypercytokinemia, or cytokine storm, is one of the severe complications viral and bacterial infections, involving release abnormal amounts cytokines, resulting in a massive inflammatory response. Cytokine storm associated with COVID-19 sepsis high mortality rate by developing epithelial dysfunction coagulopathy, leading to thromboembolism multiple organ syndrome. Anticoagulant therapy an important tactic prevent thrombosis COVID-19, but recent data show incompatibility modern direct oral...
Hypercytokinemia, or cytokine storm, often complicates the treatment of viral and bacterial infections, including COVID-19, leading to risk thrombosis. However, use currently available direct anticoagulants for COVID-19 patients is limited due safety reasons. Therefore, development new remains an urgent task organic medicinal chemistry. At same time, drugs that combine anticoagulant properties with antiviral antidiabetic activity could be helpfull in patients, especially those suffering from...
Introduction: Cardiovascular diseases are currently the leading cause of global disability and mortality. According to centers for disease control prevention, average life expectancy a person would be 10 years longer but high prevalence cardiovascular diseases, if antiplatelet drugs special therapy were used.
 Materials methods: Antiplatelet activity novel benzimidazole derivatives containing sterically hindered phenolic group in their structure has been investigated vitro, using model...
In experiments on rats, the pharmacokinetics of compound RU-891 was studied with single and multiple intravenous administration. Data linear dependence pharmacokinetic parameters are obtained. The approximation coefficient is set equal to 0.9779. Changes in a three-time administration were not detected.
Изучена острая токсичность и антиагрегантная активность нового производного бензимидазола — 2,3,4,5-тетрагидро[1,3]диазепино[1,2-a]бензимидазола (ДАБ-15) на модели АДФ, адреналин коллаген-индуцированной агрегации тромбоцитов in vitro. Соединение ДАБ-15 оказало дозозависимое антиагрегантное действие АДФ-индуцированной по EC50 превосходило ацетилсалициловую кислоту незначительно уступало тиклопидину. В отношении тромбоцитов, вызванной коллагеном адреналином, соединение достоверно препараты сравнения.
Исследована антитромботическая активность нового химического соединения производного диазепино[1,2-а]бензимидазола под шифром ДАБ-15, проявляющего высокую антиагрегантную in vitro и ex vivo. На модели генерализованного адреналин-коллагенового тромбоза было установлено, что исследуемое вещество обладает выраженным антитромбогенным эффектом превосходит референтные препараты ацетилсалициловую кислоту клопидогрел.
Введение: Тромбоциты являются ключевыми медиаторами патогенеза артериальных тромбозов и атеросклероза. Поэтому изучение антиагрегантных средств на предмет антитромботической активности различных моделях венозных является актуальным. Цель исследования: соединения РУ-1144 (производного бензимидазола) в сравнении с ацетилсалициловой кислотой (АСК) клопидогрелом артериального венозного тромбозов. Материалы методы: Артериальный тромбоз моделировали сонной артерии крыс-самцов аппликацией...
The paper presents the results of studying toxicological profile a new pharmaceutical substance RU891 with antithrombogenic properties. minimum toxic dose (TDmin) for RU-891 by peroral administration is 230 mg/kg < TDmin ≤ 460 mg/kg. In experiments on acute toxicity compound RU-891, nature and severity its damaging effect body experimental animals were established safety action was evaluated. When test sample, tolerated doses determined, most sensitive organs systems identified.
Hypercytokinemia, or cytokine storm, is one of the severe complications viral and bacterial infections, involving release abnormal amounts cytokines, resulting in a massive inflammatory response. Cytokine storm associated with COVID-19 sepsis high mortality rate by developing epithelial dysfunction coagulopathy, leading to thromboembolism multiple organ syndrome. The anticoagulant therapy an important tactic prevent thrombosis COVID-19, but recent data show incompatibility modern direct oral...
На модели артериального тромбоза сонной артерии крыс, индуцированного хлоридом железа(III) было установлено, что производное 6H-1,3,4-тиадиазина соединение L-36 превосходит по значению ЭД50 ацетилсалициловую кислоту в 3 раза. При моделировании повреждения электрическим током показано, исследуемое антитромботической активности 2,5 Проведенное исследование позволило заключить, обладает выраженной активностью.
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In this study, the antithrombotic activity of a new chemical compound benzimidazole derivative, which has shielded phenolic substituent in its structure, under laboratory code RU-1144 was studied, exhibits high antiplatelet and antioxidant vitro vivo tests. It shown that test sample pronounced effect is superior to comparison drugs acetylsalicylic acid clopidogrel model cell thrombosis generated mice.
The aim of the study was to investigate antithrombogenic properties compound RU-1144 with previously identified pronounced antiplatelet and antioxidant activities. thrombosis induced by Ferric chloride (FeCl 3 ) carried out in rats’ carotid artery, comparison known antiaggregant drugs - acetylsalicylic acid (ASA) clopidogrel, as well preparation ethylmethylhydroxypyridine succinate (EMHPS). Materials methods. antithrombotic activity studied on model rats artery thrombosis, application 50%...