A5064175209- Synthesis and Characterization of Heterocyclic Compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Reaction Mechanisms
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Synthesis and Reactivity of Heterocycles
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis of Tetrazole Derivatives
- Quinazolinone synthesis and applications
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Chemical Synthesis and Reactions
- Synthesis of heterocyclic compounds
- Crystallography and molecular interactions
- Catalytic C–H Functionalization Methods
- DNA and Nucleic Acid Chemistry
- Microwave-Assisted Synthesis and Applications
- Chemical Reactions and Mechanisms
- Synthesis and Reactions of Organic Compounds
- Fluorine in Organic Chemistry
- Adenosine and Purinergic Signaling
- Chemical Synthesis and Analysis
- Molecular Sensors and Ion Detection
- Cyclopropane Reaction Mechanisms
- Luminescence and Fluorescent Materials
Institute of Organic Synthesis
2015-2024
Ural Branch of the Russian Academy of Sciences
2009-2023
Ural Federal University
2014-2023
Russian Academy of Sciences
2008-2022
Abstract The present work reports on the synthesis of series azolo[5,1‐ c ][1,2,4]triazines and derivatives azoloazapurines. synthesized compounds were tested in vitro for antibacterial activity against N. gonorrhoeae antimycotic Trichophyton interdigitale , Epidermophyton floccosum, Microsporum canis Candida albicans . It was found that 10 3‐nitroazolo[5,1‐ ][1,2,4]triazine‐4‐amines 4 exhibit high (MIC≤15 μg/ml), but do not activity. For active a biological target predicted from...
The nitration of azolo[1,5-a]pyrimidin-7-amines with several agents (such as acetic nitric anhydride, nitronium tetrafluoroborate, and a mixture concentrated acid sulfuric acid) has been investigated. It shown that, depending on the conditions, pyrazolopyrimidin-7-amines bearing electron-withdrawing groups in pyrazole ring leads to products pyrimidine and/or ring. triazolo[1,5-a]pyrimidin-7-amines "nitrating mixture" optimized, thus allowing us obtain series...
Hypercytokinemia, or cytokine storm, often complicates the treatment of viral and bacterial infections, including COVID-19, leading to risk thrombosis. However, use currently available direct anticoagulants for COVID-19 patients is limited due safety reasons. Therefore, development new remains an urgent task organic medicinal chemistry. At same time, drugs that combine anticoagulant properties with antiviral antidiabetic activity could be helpfull in patients, especially those suffering from...
A highly efficient PASE approach to a new class of polycyclic purine derivatives has been proposed. The strategy includes consecutive reduction, auto-aromatization, and heterocyclization the initial nitrobenzimidazopyrimidines obtained by three-component condensation. It was shown that reduction metals in acidic media more than heterogeneous hydrogenation. Novel benz[4,5]imidazo[1,2-a]purines were obtained good yields proposed structure confirmed X-ray crystal analysis. convergent...
The methods for modification of azoloannulated pteridines with (hetero)aromatic nucleophiles using a nucleophilic substitution hydrogen (SNH) methodology have been developed in this work. Stable intermediate σH-adducts, as well products an unexpected intramolecular rearrangement diadducts, isolated and characterized. potential the proposed approach obtaining donor-acceptor systems, which pteridine fragment molecule acts acceptor, was demonstrated. main photophysical properties obtained D-A...
The reaction of 6-nitroazolo[5,1-c]triazines with O-methylated polyphenols, pyrrole and its benzo analogues, thiophene has been studied. Methods for the reduction nitro group in resulting σH-adducts subsequent oxidative aromatisation have developed.