A5029265901- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Chemical Reaction Mechanisms
- Quinazolinone synthesis and applications
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Heterocycles
- Synthesis of Tetrazole Derivatives
- Click Chemistry and Applications
- Microwave-Assisted Synthesis and Applications
- Synthesis and Reactions of Organic Compounds
- Crystallization and Solubility Studies
- Sulfur-Based Synthesis Techniques
- Synthesis of Organic Compounds
- Synthesis and Characterization of Pyrroles
- Synthesis and Catalytic Reactions
- Adenosine and Purinergic Signaling
- Chemical Synthesis and Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reactions and Mechanisms
- Multicomponent Synthesis of Heterocycles
- DNA and Nucleic Acid Chemistry
- X-ray Diffraction in Crystallography
Ural Federal University
2017-2024
A highly efficient approach to a new class of polycyclic 8-azapurines, benzo[4,5]imidazo[1,2-a][1,2,3]triazolo[4,5-e]pyrimidines (BITPs), with good photophysical characteristics is proposed. The comprises condensation aminobenzimidazoles 3-oxo-2-phenylazopropionitrile form 3-(arylazo)benzo[4,5]imidazo[1,2-a]pyrimidine-4-amines, which undergo oxidative cyclization by the catalytic action copper(II) acetate, resulting in BITPs 73–84% yield. Spectral investigations demonstrated fluorescent...
Abstract The present work reports on the synthesis of series azolo[5,1‐ c ][1,2,4]triazines and derivatives azoloazapurines. synthesized compounds were tested in vitro for antibacterial activity against N. gonorrhoeae antimycotic Trichophyton interdigitale , Epidermophyton floccosum, Microsporum canis Candida albicans . It was found that 10 3‐nitroazolo[5,1‐ ][1,2,4]triazine‐4‐amines 4 exhibit high (MIC≤15 μg/ml), but do not activity. For active a biological target predicted from...
To date, nitro-containing compounds form one of the most important classes organic compounds. The chemistry these molecules attracts attention primarily due to their use as high-energy reagents and drugs. Also, introduction a nitro group is popular synthetic strategy for constructing new molecules. present review summarizes latest research findings bearing on two-carbon moiety such aminonitroethylenes, α,α-bis(alkylsulfanyl)nitroalkenes amino derivatives, α-nitroketones, alkyl nitroacetates...
Today, cancer is one of the most widespread and dangerous human diseases with a high mortality rate. Nevertheless, search application new low-toxic effective drugs, combined timely diagnosis diseases, makes it possible to cure types tumors at an early stage. In this work, range polysubstituted 4,7-dihydro-6-nitroazolo[1,5-a]pyrimidines was extended. The structure all obtained compounds confirmed by data 1H, 13C NMR spectroscopy, IR elemental analysis. These were evaluated against recombinant...
4,7-Dihydro-6-nitro-7-Ar-5-R-azolo[1,5-a]pyrimidines were obtained by the multicomponent reaction of aminoazoles, morpholino-nitroalkenes, and aromatic aldehydes in catalysis boron trifluoride etherate. The optimal conditions determined, formation target regioisomer was demonstrated. pathway for transformation, including azolyl-nitroalkene, determined. Morpholino-nitroalkenes assumed to convert into corresponding nitroalkynes during For a with 4-nitrobenzaldehyde, have been proposed that...
The reaction tolerance of the multicomponent process between 3-aminoazoles, 1-morpholino-2-nitroalkenes, and aldehydes was studied. main patterns this have been established. Conditions for oxidation 4,7-dihydro-6-nitroazolo[1,5-a]pyrimidines were selected. Previous claims that could not be aromatised now refuted. Compounds with an electron-donor substituent at position seven undergo decomposition during oxidation. phenomenon explained based on experimental data, electro-chemical experiment,...
The reaction of 6-nitroazolo[5,1-c]triazines with O-methylated polyphenols, pyrrole and its benzo analogues, thiophene has been studied. Methods for the reduction nitro group in resulting σH-adducts subsequent oxidative aromatisation have developed.
A fundamentally new synthetic approach to the synthesis of 2-aminopurine has been developed. It consists in combination creation condensed polyazotic heterocyclic tetrazolopyrimidine structure, it’s transformation into triaminopyrimidine and subsequent cyclization 2-aminopurine. The structure obtained compounds was established based on spectral characteristics intermediate 5 directly by X-ray diffraction analysis.
A fundamentally new synthetic approach to the synthesis of 2-aminopurine has been developed. It consists in combination creation a condensed polyazotic heterocyclic tetrazolopyrimidine structure, its transformation into triaminopyrimidine, and subsequent cyclization 2-aminopurine. The structure obtained compounds was established based on spectral characteristics, intermediate compound 5 directly by X-ray diffraction analysis.
Azoloazine derivatives are known as promising small molecules that potentially able to counteract a broad spectrum of RNA viruses including SARS‐CoV‐2. However, pool synthetic pathways provide convenient structural modification such compounds without de novo construction the heterocyclic scaffold is rather limited so far. This work proposes an approach direct C(sp2)–H functionalization azolopyrimidine substrates with aromatic thiol residues, mediated by iodine/persulfate reagent system. The...
In this work, we have developed a method for synthesizing new 8-substituted triazolo[5,1-b]purines using diacetoxyiodobenzene as an oxidizing agent with good yields (59–67%). The advantages of approach include mild reaction conditions and removing the need to use transition metals. Based on results obtained, plausible pathway was proposed. opens possibilities preparation previously inaccessible condensed purine derivatives, which are interest development biomolecules variety pharmacological...
The nucleophilic substitution of the nitro group 4-alkyl-6-nitro-4,7-dihydro-1,2,4-triazolo[5,1-c][1,2,4]triazine-7-ones on example interactionwith morpholine was studied. It is established that under action excess cycloalkylimine at room temperature unusual easy disclosure triazine cycle with formation sterically hindered hydrazones occurs which are key intermediates for further transformations. carrying reaction elevated temperatures leads to products amine and also morpholyl hydrolysis...
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