A5050701429- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Luminescence and Fluorescent Materials
- Synthesis and Biological Evaluation
- Organic Light-Emitting Diodes Research
- Molecular Sensors and Ion Detection
- Cholinesterase and Neurodegenerative Diseases
- Fluorine in Organic Chemistry
- Advanced Photocatalysis Techniques
- Computational Drug Discovery Methods
- TiO2 Photocatalysis and Solar Cells
- Organic Electronics and Photovoltaics
- Quinazolinone synthesis and applications
- Synthesis and Reactions of Organic Compounds
- Synthesis and Properties of Aromatic Compounds
- Chemical synthesis and alkaloids
- biodegradable polymer synthesis and properties
- Lanthanide and Transition Metal Complexes
- Synthesis of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Crystal structures of chemical compounds
- Synthesis and Reactivity of Heterocycles
- Polymer Synthesis and Characterization
- Carbon dioxide utilization in catalysis
Ural Branch of the Russian Academy of Sciences
2013-2024
Institute of Organic Synthesis
2012-2024
Russian Academy of Sciences
2012-2023
Ural Federal University
2014-2022
A series of previously synthesized conjugates tacrine and salicylamide was extended by varying the structure fragment using salicylic aldehyde to synthesize salicylimine derivatives. The hybrids exhibited broad-spectrum biological activity. All new were potent inhibitors acetylcholinesterase (AChE) butyrylcholinesterase (BChE) with selectivity toward BChE. moiety exerted little effect on anticholinesterase activity, but AChE inhibition increased spacer elongation. most active derivatives:...
Abstract New conjugates of tacrine and salicylamide with alkylene spacers were synthesized evaluated as potential multifunctional agents for Alzheimer's disease (AD). The compounds exhibited high acetylcholinesterase (AChE, IC 50 to 0.224 μM) butyrylcholinesterase (BChE, 0.0104 inhibitory activities. They also rather poor inhibitors carboxylesterase, suggesting a low tendency exert unwanted drug‐drug interactions in clinical use. mixed‐type reversible both cholinesterases demonstrated dual...
Abstract Random copolymers of styrene and substituted styrenes bearing arylamino substituents as fluorophore units have been obtained. Their photophysical properties investigated by measuring absorption emission spectra in solutions solid‐state. All proved to possess absolute quantum yields up 0.39 solution 0.05 solid‐state, depending on their substituents. Fluorescence studies shown that these show a highly sensitive response towards diversity nitroaromatic compounds, both vapor phase. The...
We have designed novel push–pull systems based on CF3-substituted pyridines and pyrimidines. The photophysical properties of these new fluorophores been examined using both absorption emission spectral analyses in acetonitrile solutions solid states. All proved to exhibit moderate absolute quantum yields up 0.33 0.12 states, depending their specific structures. Most demonstrated significant aggregation-induced behavior, making them suitable as robust low-toxicity bioimaging agents for...
The well-known fluorophore, namely 1,3,6,8-tetrakis[(trimethylsilyl)ethynyl]pyrene, has been studied profoundly as a fluorescent sensor toward nitroaromatic compounds in solutions and vapor phase. Three prototypes of materials for sensing were prepared via electrospinning drop-casting onto the melamine formaldehyde foam with fluorophore pure solid or dopant polystyrene matrix. It shown that this based on it have high detection limits within range 10−8 to 10−9 M acetonitrile solution up ppb...
New donor–π–acceptor pyrimidine-based dyes comprising an amide moiety as anchoring group have been designed. The were synthesized by sequential procedures based on the microwave-assisted Suzuki cross-coupling and bromination reactions. influence of dye structure length π-linker photophysical electrochemical properties photovoltaic effectiveness dye-sensitized solar cells was investigated. An increase in efficiency with a decrease revealed. D1 only one 2,5-thienylene-linker provided highest...
Alzheimer's disease (AD) is considered a modern epidemic because of its increasing prevalence worldwide and serious medico-social consequences, including the economic burden treatment patient care. The development new effective therapeutic agents for AD one most urgent challenging tasks. To address this need, we used an aminoalkylene linker to combine well-known anticholinesterase drug tacrine with antioxidant 2-tolylhydrazinylidene-1,3-diketones create 3 groups hybrid compounds as...
Five random copolymers comprising styrene and with pendant fluorophore moieties, namely pyrene, naphthalene, phenanthrene, triphenylamine, in molar ratios of 10:1, were synthesized employed as fluorescent sensors. Their photophysical properties investigated using absorption emission spectral analyses dichloromethane solution solid state. All possessed relative quantum yields up to 0.3 absolute 0.93 state, depending on their components. Fluorescence studies showed that the these is highly...
A convenient approach to [1,2,5]oxadiazolo[3',4':5,6]pyrazino[2,3-b]indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald-Hartwig subsequent annulation by intramolecular oxidative cyclodehydrogenation. The photophysical properties for new polycycles have measured.
We report on the synthesis and temperature-dependent magnetic properties observed in an exchange-coupled copper(II) dimer using X/Q-band Electron Paramagnetic Resonance (EPR) spectroscopy (9/34 GHz). It has been found that zero-field splitting (D) changes gradually by a factor close to two temperature range from T = 50 300 K. X-ray diffraction data show this consists of five-coordinated copper ions, one which highly asymmetric geometry intermediate between square pyramid trigonal bipyramid....
The methods for modification of azoloannulated pteridines with (hetero)aromatic nucleophiles using a nucleophilic substitution hydrogen (SNH) methodology have been developed in this work. Stable intermediate σH-adducts, as well products an unexpected intramolecular rearrangement diadducts, isolated and characterized. potential the proposed approach obtaining donor-acceptor systems, which pteridine fragment molecule acts acceptor, was demonstrated. main photophysical properties obtained D-A...
The possibility of functionalization 2-(polyfluorophenyl)-4H-chromen-4-ones, with them having different numbers fluorine atoms, 1,2,4-triazole or imidazole under conditions base-promoted nucleophilic aromatic substitution has been shown. A high selectivity mono-substitution was found the use an azole (1.5 equiv.)/NaOBut(1.5 equiv.)/MeCN system. structural features fluorinated mono(azolyl)-substituted flavones in crystals were established using XRD analysis. ability penta- and...
Design and synthesis of 2-(aryl/thiophen-2-yl)quinazolin-4(3H)-ones 4-cyano-2-arylquinazolines with Et2N-, Ph2N- or carbazol-9-yl- electron donating fragment are described. The key photophysical properties these compounds have been studied by UV/Vis absorption fluorescence spectroscopy in solvents different polarity (toluene MeCN). 2-(Aryl/thiophen-2-yl)quinazolin-4(3H)-ones show blue-green region toluene solution quantum yields up to 89% the case...