A5001090844- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical Synthesis and Analysis
- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Crystallography and molecular interactions
- Viral Infections and Vectors
- Biochemical and Molecular Research
- Synthesis and Biological Evaluation
- Asymmetric Synthesis and Catalysis
- Click Chemistry and Applications
- Analytical Chemistry and Chromatography
- Synthesis and Characterization of Heterocyclic Compounds
- Mosquito-borne diseases and control
- Amino Acid Enzymes and Metabolism
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Zoonotic diseases and public health
- Chemical synthesis and pharmacological studies
- Multicomponent Synthesis of Heterocycles
- DNA and Nucleic Acid Chemistry
- HIV/AIDS drug development and treatment
- Synthesis and Biological Activity
- Nonlinear Optical Materials Research
- Glycosylation and Glycoproteins Research
- Yersinia bacterium, plague, ectoparasites research
Institute of Organic Synthesis
2011-2023
Ural Branch of the Russian Academy of Sciences
2004-2023
Russian Academy of Sciences
2015-2020
Novel conjugates of 2‐aminopurine and purine containing fragments chiral heterocyclic amines attached at position 6 core via a linker, fragment omega‐amino acid, have been synthesized evaluated in vitro for their anti‐herpetic activity the Vero E6 cells; as result, new group compounds possessing high inhibitory against herpes simplex virus type 1, including acyclovir‐resistant (TK – ) strain has revealed. The is substantially dependent on stereo configuration amine.
Abstract On the basis of results obtained from NMR spectroscopy, X‐ray analysis and chemical transformations, it was established that acidic hydrolysis (2 S ,4 )‐4‐arylaminoglutamates in formation lactams which ring closure occurs with participation γ‐amino α‐COOH groups; but isomeric resulting α‐amino γ‐COOH groups are not formed. Isomeric lactams, is, )‐4‐arylamino‐5‐oxoprolines, can be easily converted medium into more stable 4‐amino‐1‐aryl‐5‐oxoprolines. (© Wiley‐VCH Verlag GmbH &...
Abstract The possibility of obtaining the stereoisomeric derivatives 5‐oxoproline and glutamic acid with a tertiary amino group at C‐4, using nucleophilic substitution bromine in dimethyl (2 S ,4 RS )‐4‐bromo‐ N ‐phthaloylglutamate secondary amines followed by resolution diastereomers removal protecting groups has been studied. We have shown that reaction arylamines results optically pure high yields. In case more basic amines, is accompanied racemization, target products can be isolated...
Abstract Reduction of the carbonyl groups in N ‐protected (2 S ,4 )‐4‐amino‐5‐oxo‐1‐phenylprolinates with BH 3 complexes resulted ,4S)‐4‐aminoproline or )‐4‐aminoprolinol derivatives depending on reaction conditions and type protecting used.
Venous thromboembolism is a serious problem because it significantly increases the risk of developing vascular complications in elderly patients with obesity or immobilization, cancer, and many other diseases. Thus, there need to study new therapeutic strategies, including medicinal agents for efficient safe correction thrombus disorders. In this work, we have synthesized number amides peptides 4-amino-5-oxoprolines studied their antiplatelet antithrombotic activity experiments vitro vivo....