A5101566312- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Adipose Tissue and Metabolism
- Cardiomyopathy and Myosin Studies
- Muscle metabolism and nutrition
- Biomedical and Engineering Education
- RNA Interference and Gene Delivery
- Animal testing and alternatives
- Williams Syndrome Research
- Health and Medical Research Impacts
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Adolescent and Pediatric Healthcare
- Advanced Proteomics Techniques and Applications
- Viral Infections and Immunology Research
- Click Chemistry and Applications
- CRISPR and Genetic Engineering
- Peroxisome Proliferator-Activated Receptors
- Viral Infectious Diseases and Gene Expression in Insects
- Endoplasmic Reticulum Stress and Disease
- Nanoparticle-Based Drug Delivery
- Inflammatory mediators and NSAID effects
- Pluripotent Stem Cells Research
- Health Systems, Economic Evaluations, Quality of Life
- 3D Printing in Biomedical Research
Binghamton University
2018-2020
Children's National
2007-2015
Johns Hopkins University
2000
A new line of dystrophic mdx mice on the DBA/2J (D2) background has emerged as a candidate to study efficacy therapeutic approaches for Duchenne muscular dystrophy (DMD).These harbor genetic polymorphisms that appear increase severity dystropathology, with disease modifiers also occur in DMD patients, making them attractive studies and drug development.This workshop aimed at collecting consolidating available data pathological features natural history these D2/mdx mice, comparison classic...
Time series profiling is a powerful approach for obtaining information on protein expression dynamics and prevailing biochemical pathways. To date, such could only be obtained at the mRNA level using mature highly parallel technologies as microarray gene profiling. The generation of time data has lagged due to lack robust reproducible methodologies. Using combination SILAC strategy, SDS-PAGE LC-MS/MS, we demonstrate successful monitoring levels same set proteins across different points...
Recent years witnessed an exciting increase in the number of clinical trials for neuromuscular disorders, particular Duchenne Muscular Dystrophy and Spinal Muscle Atrophy. Given high emotional impact such developments devastating diseases with urgent medical need, it is particularly important to justify human on basis robust preclinical studies avoid a waste hopes funds.This review focuses discussion quality conduct clinically-oriented assessments rare disease models importance reporting...
A workshop took place in 2015 to follow up TREAT-NMD activities dedicated improving quality the preclinical phase of drug development for neuromuscular diseases. In particular, this adressed necessary future steps regarding common standard experimental protocols and issue translatability efficacy studies.
Urine is increasingly being considered as a source of biomarker development in Duchenne Muscular Dystrophy (DMD), severe, life-limiting disorder that affects approximately 1 4500 boys. In this study, we the mdx mice—a murine model DMD—to discover biomarkers disease, well pharmacodynamic responsive to prednisolone, corticosteroid commonly used treat DMD. Longitudinal urine samples were analyzed from male age-matched and wild-type mice randomized prednisolone or vehicle control via liquid...
Abstract Urine is increasingly being considered as a source of biomarker development in Duchenne Muscular Dystrophy (DMD), severe, life-limiting disorder that affects approximately 1 4500 boys. In this study, we used the mdx mice—a murine model DMD—to discover biomarkers disease, well pharmacodynamic responsive to prednisolone, commonly treat DMD. Longitudinal urine samples were analyzed from male age-matched and wild-type mice randomized prednisolone or vehicle. We high-resolution mass...