A5064466931- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Head and Neck Cancer Studies
- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- Ear and Head Tumors
- Dermatology and Skin Diseases
- Head and Neck Surgical Oncology
- Plant Virus Research Studies
- Cancer Diagnosis and Treatment
- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Urticaria and Related Conditions
- Genetic and rare skin diseases.
- Tumors and Oncological Cases
- Salivary Gland Tumors Diagnosis and Treatment
- Antenna Design and Analysis
- Skin Protection and Aging
- Medicine and Dermatology Studies History
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Psoriasis: Treatment and Pathogenesis
- CAR-T cell therapy research
New York University
2021-2024
NYU Langone Health
2024
Yale University
2016-2022
Harvard University
2019
VA Connecticut Healthcare System
2019
Yale Cancer Center
2019
University of New Haven
2018
American University of Beirut
2016
University of Pennsylvania
2014-2015
Renal ischemia-reperfusion injury (IRI) is a common cause of renal dysfunction and failure. Histone/protein deacetylases (HDACs) regulate gene accessibility higher order protein structures may alter cellular responses to variety stresses. We investigated whether use pan- class-specific HDAC inhibitors (HDACi) could improve IRI tolerance in the kidney. Using model unilateral IRI, we early function after calculated fibrosis using an automated scoring system. found that pan-HDAC inhibition...
Abstract Background Evidence surrounding the effect of adjuvant treatment in salivary gland cancers is limited. The benefit adding chemotherapy to also interest. We investigated association these treatments with survival and whether this differed by stage or presence adverse features. Methods A retrospective study adult cancer cases diagnosed from 2004 2013 National Cancer Data Base (NCDB) was conducted. Results Treatment radiotherapy associated improved for both patients early‐stage (hazard...
Oral cavity cancer is the most commonly occurring malignancy of head and neck. There are limited data suggesting a change in prognosis oral cancers. We aimed to evaluate temporal trends demographics, treatment, diagnosed between 1973 2014 inclusive.Retrospective database analysis.A retrospective study 16,030 adult patients with inclusive treated surgically Surveillance, Epidemiology, End Results (SEER) 9 registry was conducted. A supplemental analysis conducted using from National Cancer...
Melanoma is among the most common malignant neoplasms in United States, with 91 270 cases estimated to be diagnosed 2018. Since 2012, Mohs micrographic surgery (MMS) has gained popularity treatment of melanoma situ. Although current guidelines for invasive without nodal metastases recommend wide margin excision (WME), use MMS this disease increased as well, particularly early stages. How survival outcomes after each procedure compare one another early-stage unknown date.To evaluate overall...
Objective To identify and compare treatment system factors associated with survival in early‐stage glottic cancer. Study Design Retrospective study of cases the Commission on Cancer National Database. Methods Adult patients early cancer (stage I or II) diagnosed between January 1, 2004, December 31, 2012, were included. Demographic, tumor, variables included analyses. Multivariate Cox regressions as well univariate Kaplan‐Meier analyses conducted. Results In total, 5,627 study. Treatment...
BACKGROUND The growing epidemic of human papillomavirus‐positive (HPV+) oropharyngeal cancer and the favorable prognosis this disease etiology have led to a call for deintensified treatment some patients with HPV+ cancers. One proposed methods deintensification is avoidance chemotherapy concurrent definitive/adjuvant radiotherapy. To authors' knowledge, safety form de‐escalation unknown current literature in area sparse. authors investigated outcomes after various combinations stratified by...
Objectives Approximately 3% to 9% of head and neck cancer presents with a metastatic node no identifiable primary tumor. These cases carcinoma unknown (HNCUP) present therapeutic challenge. Therapy this disease varies based on factors such as institutional, surgeon, patient preference. Evidence demonstrating the outcomes associated these therapies for HNCUP is limited, among available series, tumor human papillomavirus (HPV) status often ignored. Treatment deintensification has been proposed...
Though described as an important prognostic indicator, facility case volume thresholds for patients with head and neck squamous cell carcinoma (HNSCC) have not been previously developed to date.To identify of facilities that manage HNSCC.Retrospective analysis 351 052 HNSCC cases reported from January 1, 2004, through December 31, 2014, by Commission Cancer-accredited cancer centers the US National Cancer Database. Data were analyzed August 2018, April 5, 2019.Treatment at varying...
Ichthyoses are clinically and genetically heterogeneous disorders characterized by scaly skin. Despite decades of investigation identifying pathogenic variants in more than 50 genes, clear genotype-phenotype associations have been difficult to establish. To expand the genotypic phenotypic spectra ichthyosis delineate associations. This cohort study recruited an international group individuals with describes characteristic distinguishing features common genotypes, including associations,...
Merkel cell carcinoma (MCC) is a rare cutaneous malignant neoplasm with increasing incidence and high mortality. Although it accepted that the optimal treatment for localized tumors surgical, data surrounding surgical approach are mixed, current National Comprehensive Cancer Network guidelines state Mohs micrographic surgery (MMS) wide local excision (WLE) can both be used. The do not advocate preference MMS or WLE suggest they used interchangeably.
Objective Oral cavity cancer is the most common malignant disease of head and neck. The natural course poorly characterized unavailable for patient consideration during initial treatment planning. Our primary objective was to outline this history, with a secondary aim identifying predictors refusal. Study Design Retrospective review adult patients oral who refused surgery that recommended by their physician in National Cancer Database. Methods Demographic, tumor, survival variables were...
Wider cleft palates are thought to be associated with increased complications and poorer outcomes following palate repair. Objective photographic measurement assessment of have not been previously performed. The purpose this study is quantitatively characterize a series dimensions investigate possible correlations Veau classification intra-, peri-, postoperative outcomes.The analytic sample included primary repairs performed by the senior author over 2-year period. Standard photographs...
Merkel cell carcinoma (MCC) carries the highest mortality rate among cutaneous cancers and is rapidly rising in incidence. Identification of prognostic indicators may help guide patient counseling treatment planning. Lymph node ratio (LNR), positive lymph nodes to total number examined nodes, an established indicator other cancers.The primary objective was evaluate association between LNR survival after surgery for node-positive MCC. The secondary whether rates associated with adjuvant...
Objective After radiation failure for early T‐stage larynx cancer, national guidelines recommend salvage surgery. Total laryngectomy and conservation laryngeal surgery with an open or endoscopic approach are both used. Beyond single‐institution studies, there is a lack of evidence concerning the outcomes these procedures. We aim to study whether treatment associated poorer than total as after T1/T2 cancers. Study Design A retrospective was conducted adult squamous cell cancer cases in...
To characterize treatment delays in surgically treated oropharyngeal cancer, identify factors associated with delays, and associate survival.Retrospective cross-sectional analysis.Commission on Cancer-accredited institutions.We identified patients the National Cancer Database cancer. We characterized durations of diagnosis-to-treatment initiation, surgery-to-radiation treatment, radiation duration, total package, end intervals as medians. patient, tumor, via multivariable logistic regression...
Abstract Histone/protein deacetylases (HDAC) 1 and 2 are typically viewed as structurally functionally similar enzymes present within various co-regulatory complexes. We tested differential effects of these isoforms in renal ischemia reperfusion injury (IRI) using inducible knockout mice found no significant change ischemic tolerance with HDAC1 deletion, but mitigation HDAC2 deletion. Restriction deletion to the kidney via transplantation or PAX8-controlled proximal tubule-specific Cre...
Objective Salivary squamous cell carcinomas (SCCs) represent a unique disease entity because many are thought to metastases from primary cutaneous malignancies. Nevertheless, they significant proportion of parotid gland cancers and have notably poor prognosis. Recently, there has been controversy regarding the utility adjuvant chemotherapy in treatment these malignancies, with most studies concluding that is no survival benefit. We aim determine outcomes associated use radiotherapy...
Objectives To analyze the incidence and clinical profile of nonsquamous cell (non‐SCC) laryngeal carcinomas to effect surgery on survival. Study Design A retrospective analysis National Cancer Database (2004–2014). Methods Adult patients with non‐SCC cancers were divided into six major histological subtypes. descriptive was obtained for patients, multivariate regressions performed survival within cohort. Results We identified 878 cases cancers, representing 1.02% all malignant cancers....