A5035067201- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Gold and Silver Nanoparticles Synthesis and Applications
- Antimicrobial Peptides and Activities
- Nanocluster Synthesis and Applications
- Photodynamic Therapy Research Studies
- MicroRNA in disease regulation
- Ultrasound and Hyperthermia Applications
- Prion Diseases and Protein Misfolding
- Bacteriophages and microbial interactions
- Advanced Nanomaterials in Catalysis
- Microfluidic and Bio-sensing Technologies
- Ultrasound and Cavitation Phenomena
- Photoacoustic and Ultrasonic Imaging
- Biosensors and Analytical Detection
- Cervical Cancer and HPV Research
Southwest University
2010-2025
Beijing University of Chemical Technology
2023
Jining Medical University
2023
Cationic photosensitizers have good binding ability with negatively charged bacteria and fungi, exhibiting broad applications potential in antimicrobial photodynamic therapy (aPDT). However, cationic often display unsatisfactory transkingdom selectivity between mammalian cells pathogens, especially for eukaryotic fungi. It is unclear which biomolecular sites are more efficient damage, owing to the lack of systematic research same photosensitizer system. Herein, a series aggregation-induced...
Challenges remained in precisely real-time monitoring of apoptotic molecular events at the subcellular level. Herein, we developed a new type intelligent DNA biocomputing nanodevices (iDBNs) that responded to mitochondrial microRNA-21 (miR-21) and microRNA-10b (miR-10b) simultaneously which were produced during cell apoptosis. By hybridizing two hairpins (H1 H2) onto nanospheres (DNSs) had been previously modified with mitochondria-targeted triphenylphosphine (TPP) motifs, iDBNs assembled...
Monitoring apoptosis in breast cancer cells is crucial for understanding the molecular mechanisms underlying and evaluating therapeutic effects of anticancer drugs. Real-time monitoring p21 mRNA Bax during offers a valuable tool assessing drug efficacy. Tetrahedral DNA frameworks (TDFs) are known their ease synthesis multiple signal outputs. Leveraging these properties, this study developed dual-color probes (DDCPs) real-time cells. In presence mRNA, strand displacement reactions within...
As an important barrier between the cytoplasm and microenvironment of cell, cell membrane is essential for maintenance normal cellular physiological activities. An abnormal a crucial symbol body dysfunction occurrence variant diseases; therefore, visualization monitoring biomolecules associated with membranes disease markers are utmost importance in revealing biological functions membranes. Due to their biocompatibility, programmability, modifiability, DNA nanomaterials have become...
In this contribution, we report a molecular recognition between adenosine and its aptamer, which leads to the formation of four-stranded tetraplex structures (G-quartet) aptamer. It is found that formed G-quartet could induce side-by-side self-assembly gold nanorods (AuNRs) owing electrostatic interaction positive charge cetyltrimethylammonium bromide (CTAB) on AuNR surface negative G-quartet. Furthermore, AuNRs characterized by enhancement plasmon resonance light scattering (PRLS) signals...
We report a novel strategy to fabricate metal nanoparticle/carbon nanotube hybrids with unique plasmon properties as well biocompatibility and further apply them efficient dark field light scattering agents for cancer cell imaging.
Polyvalent ligand-induced cell receptor aggregation is closely related to behavior regulation. At present, most of the means induce rely on external stimuli such as light, heat, and magnetic fields, which may cause side effects normal cells. How achieve cancer surface apoptosis selectively still a challenge. Therefore, by taking advantage unique property cells' slightly acidic microenvironment, an easy-to-use apoptosis-inducing mode for in situ activation nucleolin clustering has been...