A5047306889- Epilepsy research and treatment
- Anesthesia and Neurotoxicity Research
- Neonatal and fetal brain pathology
- Cytokine Signaling Pathways and Interactions
- Metabolism and Genetic Disorders
- Neurological Disorders and Treatments
- Urinary Tract Infections Management
- Urinary Bladder and Prostate Research
- Genetics and Neurodevelopmental Disorders
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Pediatric Urology and Nephrology Studies
- Language Development and Disorders
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects and Toxicity Studies
- Congenital heart defects research
- Attention Deficit Hyperactivity Disorder
- Infectious Disease Case Reports and Treatments
- Medical and Biological Sciences
- Chronic Lymphocytic Leukemia Research
- Migraine and Headache Studies
- Bladder and Urothelial Cancer Treatments
- Immune Cell Function and Interaction
- Renal Diseases and Glomerulopathies
Kazan State Medical Academy
2012-2024
Russian Medical Academy of Continuous Professional Education
2022-2024
City Clinical Hospital No. 2
2019
Nizhny Novgorod Regional Clinical Hospital named after Semashko
2019
Institute of Clinical and Experimental Lymphology
2017
Institute of Molecular Biology and Biophysics
2016
Institute of Bioorganic Chemistry
2014
BIOCAD (Russia)
2012
Ministry of Health of the Russian Federation
2012
City Children's Hospital No. 22
2012
Аbstract. The aim of present study was to investigate an influence polyclonal activators upon cytokine-producing function peripheral blood cells in the patients with colorectal adenocarcinomas. It revealed that stimulated production IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whole treated significantly decreased cancer patients, as compared healthy individuals. IL-1ra IL-17 depressed during tumor progression, along increased release TNFα IL-8. found stimulation index (i.e., a cytokine...
Aim: According to the current data, a major factor for phenotypic variation of complex traits and disease susceptibility is cis-acting effects noncoding variants on gene expression. Our purpose was evaluate association between colorectal cancer (CRC) six single nucleotide polymorphisms identified using our original bioinformatics approach as regulatory putatively related CRC. Materials: One hundred sixty CRC patients 185 healthy controls have been genotyped rs590352, rs2072580, rs78317230,...
The patients with gastrointestinal cancer exhibit high contents of TNFα, IL-1β, IL-2, IL-6, IL-8, IFNγ, IL-1Ra and increased levels anti-IFNα antibodies. Significant correlations are detected between histopathological parameters the tumors, IFNα, as well antibodies against TNFα и IFNα. Moreover, we have determined diagnostically significant cytokines their combinations. On basis estimated diagnostic values, one may evaluate both current status tumor, its potential malignancy grade.
We studied biological effects of Human Leukemia Differentiation Factor (HLDF), first derived from the cultural media human myelogenous HL-60 leukemia cells, on production IL-1β, IL-1ra and IL-8 by immune cells patients with chronic atrophic gastritis, adenomas adenocarcinomas stomach. To evaluate influence HLDF cytokine-producing function whole blood latter were incubated this factor or without it. The levels determined in supernates these cells. stimulation indices upon cytokine estimated...
Background. Real world data help to provide more information on the effects and tolerability of therapy. However, use perampanel in Russian population children remain limited. Aim. To conduct a retrospective analysis efficacy adolescents with epilepsy real clinical practice. Materials methods. A total 106 aged 4–18 years receiving as part combination therapy for were observed at 18 centers. Seizure frequency 1–3, after 6 12 months treatment, presence type adverse events (AEs) analyzed. The...
This paper describes two cases of congenital bilateral perisylvian syndrome (CBPS), a rare disorder late neuronal migration, which is characterized by language delay, intellectual disorders, epilepsy and polymicrogyria. Pseudobulbar paralysis orofacial muscles dyspraxia causing drooling feeding difficulties are common for patients with CBPS. Communicational problems lead to low self-esteem social maladaptation. Literature data regarding correlation between polymicrogyria topography speech...
The epilepsy treatment is to be based on existing general principles and standards of therapy with differential approach each patient. Besides peculiarities different types seizures forms there are also approaches special groups patients. To one such referred women reproductive age. These patients group risk due the development of certain side effects antiepileptic drugs (АED). This article focuses in details peculiarities age with accent made tolerability safety therapy. It necessary take...
The complex mechanism of epileptogenesis has not been adequately explored. Perinatal brain pathology is one the most important triggers epilepsy in children. paper gives data on course and transformation epileptic seizures children who have verified perinatal problems. A study 66 with perinatally induced provided evidence for evolution impairments cerebral hemodynamics neuroimaging phenomena examined contingent patients.
Aim – analyze the current practice of management in patients with neonatal seizures and perinatal brain disorders, determine ways to prevent long-term neurological complications. Materials methods. The study group included 140 children (aged from 2 weeks 18 months) abnormalities. In these cases, obstetric early postnatal history was analyzed; all underwent video-EEG monitoring, cervical spine X-ray, neuroimaging, a Doppler ultrasound test. Results. We found number reliable ante- intra-...
Background: Autoimmune hemolytic anemia (AIHA) and pure red cell aplasia (PRCA) are well recognized autoimmune complications (AIC) of chronic lymphocytic leukemia (CLL). Both AIHA PRCA complicate patient management, have significant impact on quality life can be fatal. Ibrutinib is an irreversible inhibitor BTK ITK (interleukin‐2 inducible tyrosine kinase), mediating antibody dependent cellular cytotoxicity, which makes it attractive in treatment AIC the context CLL. We present a pre‐planned...
The review is devoted to common epilepsy of childhood — absence epilepsy. This epileptic syndrome debuts at pre-school age and characterized by frequent seizures which may be underestimated doctors due the clinical features a seizure. can debilitate child restrict socialization, as specific comorbidities in cognitive field are very for etiology neropsychiatric different. Seizures, discharges, well interictal epileptiform activity brain cause neuropsychological impairments children....
The article presents a case report, and literature review on benign epileptiform discharges of childhood (BEDC) as well effect this type activity speech, behavior communication skills are analyzed. incidence BEDC comprises 5% in pediatric population. Examining children with autistic spectrum disorder, is revealed 20% cases, whereas those attention deficit hyperactivity disorder (ADHD) or speech – 25% 18% respectively. Many studies considering genetic marker brain immaturity highlighted by...
The study involved 107 women aged 20 to 52 years with chronic recurrent cystitis (57 of them leukoplakia) developing under conditions a pathogenic and/or opportunistic infection. All patients underwent conventional clinical and instrumental examination. Biopsy samples for culture-based microscopic examination were taken from the area Pawlik’s trigone vagina Lieutaud’s urinary bladder, in case leukoplakia — field visually healthy tissue. carried out cytomorphological analysis assessment...
Epileptiform EEG changes are much more common in children whose parents epileptic than the population. There is evidence that subclinical epileptiform activity affects children’s intellect and behavior. These need timely detection therapy. Objective : to determine specific features rates of abnormalities born with epilepsy. Patients methods. The brain bioelectrical 47 fathers, 53 mothers, 46 healthy (a control group) was evaluated via video monitoring method on an Encephalan 9 apparatus...
Antibodies to leukemia differentiation factor (HLDF) in patients with gastrointestinal cancer Abstract. Patients gastric exhibit higher levels of IgG4-antibodies human (HLDF), as compared healthy individuals, whereas, colorectal cancer, one may detect high IgA anti-HDLF antibodies, along lower IgG1 class antibodies against HLDF than control group. Among a positive correlation is revealed between contents highly differentiated cells the tumor, and IgM HDLF. Meanwhile, reverse relationship...
The contents of peripheral blood cells expressing activation markers are increased in patients with gastrointestinal malignancies, mostly cases gastric cancer. An association is revealed between the immunological parameters and histopathological features. Absolute lymphocytes CD71+ HLA-DR+ phenotype, showing a significantly correlation most pathological tumors, may be considered as an informative marker tumor progression at pre-surgical step. (Med. Immunol., 2008, vol. 10, N 2-3, pp 181-186).
In vitro response of blood mononuclear cells to cancer-associated antigens was studied in women with genital pathology, and these results were compared serum levels pro- anti-inflammatory factors immunity, like as histological features cancer cervical epithelial dysplasia. cellular regarded positive, if relative amounts CD8-positive lymphocytes increased by > 15% following incubation mononuclears antigens. Positive reaction elevated anti-TNFα anti-IFNγ antibodies associated lesser...