A5049417331- Epilepsy research and treatment
- Genomics and Rare Diseases
- Migraine and Headache Studies
- Neurological Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Genetics and Neurodevelopmental Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Neuroscience and Neuropharmacology Research
- Hereditary Neurological Disorders
- Cytomegalovirus and herpesvirus research
- Healthcare Systems and Public Health
- Chemical Reactions and Isotopes
- Child Nutrition and Feeding Issues
- Child and Adolescent Psychosocial and Emotional Development
- Autoimmune Neurological Disorders and Treatments
- interferon and immune responses
- Photodynamic Therapy Research Studies
- Fungal Infections and Studies
- Toxin Mechanisms and Immunotoxins
- Pharmaceutical studies and practices
- Ophthalmology and Eye Disorders
- Neuroscience of respiration and sleep
- Tuberous Sclerosis Complex Research
- Neurofibromatosis and Schwannoma Cases
- Antifungal resistance and susceptibility
Tyumen State Medical University
2013-2025
Background. There is no doubt that genetic testing should be one of the main studies in modern clinical diagnosis epileptic syndromes. Aim. To describe and compare spectrum detected gene mutations patients with epilepsy developmental encephalopathies (DEE) over last 3 years practice neurologists-epileptologists, including: analysis diagnosed syndromes, timing etiological diagnosis, treatment options effectiveness. Materials methods. A multicenter retrospective study including any age gender...
The article summarizes the introduction of drugs into cerebrospinal fluid. Indications and contraindications for administration pharmaceuticals in fluid spaces are presented. Main groups pharmacological agents used endolumbar conditions under which they used, as well advantages disadvantages this treatment considered. authors describe a method antibiotics bacterial fungal infections central nervous system. need to assess intracranial pressure prior cisternal puncture exclude blocking...
<h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Описать спектр выявляемых генных мутаций у пациентов с эпилепсией в повседневной клинической практике, включая анализ диагностированных эпилептических синдромов, характера приступов, сроков постановки генетического диагноза, вариантов и эффективности лечения. <h3>МАТЕРИАЛ И МЕТОДЫ</h3> В исследование были включены 100 (40 мальчиков, 60 девочек) и/или эпилептической энцефалопатией верифицированными генными мутациями. Средний возраст составил 6,9±5,1 года. Через...
Background. The problem of antiepileptic therapy in children remains highly relevant due to the insufficient efficacy standard drugs, adverse events, and limitations clinical guidelines. Aim. To assess efficacy, tolerability, continuation zonisamide (Zonegran) with epilepsy. Materials methods. This retrospective multicenter study was conducted epileptology centers various regions Russian Federation, including Moscow, Novosibirsk, Krasnodar, Tyumen, Krasnoyarsk, Voronezh, Ryazan). We included...
Developmental and epileptic encephalopathies (DEE) are the most difficult problem in epileptology. Lennox — Gastaut syndrome (LGS) is a developmental encephalopathy with onset childhood, manifested by: frequent polymorphic seizures, including tonic axial ones; severe cognitive impairment; slow activity (with frequency of <2.5–3.0 Hz) sharp-slow wave interictal period on electroencephalogram, as well runs fast 10–20 Hz, often associated seizures; resistance to therapy. Presumably genetic...
Background. Real world data help to provide more information on the effects and tolerability of therapy. However, use perampanel in Russian population children remain limited. Aim. To conduct a retrospective analysis efficacy adolescents with epilepsy real clinical practice. Materials methods. A total 106 aged 4–18 years receiving as part combination therapy for were observed at 18 centers. Seizure frequency 1–3, after 6 12 months treatment, presence type adverse events (AEs) analyzed. The...
Background. Comparative study of antiepileptic drugs allows to make the optimal choice in therapy. The aim study: a comparative analysis administration two similar by chemical structure (zonisamide and topiramate) outpatient practice epilepsy children, taking into account efficacy tolerability. Materials methods. A retrospective charts equal number (n = 18) groups patients with different forms treated zonisamide topiramate monotherapy combined therapy was carried out. Results. In general, no...
Epilepsy is a chronic brain disease that requires long-term or lifelong follow-up of patients. The factors influence the outcome therapy are various; moreover, key them organization care and mode patient follow-up. necessity optimizing specialized health to this category patients stems from poorer quality life in their families more frequent development mental disorders drug-resistant forms during ineffective therapy. These other issues considered paper with emphasis on specific area – south...
Background: Given the significant share of gene mutations in etiology epilepsy, it is important for practitioners to evaluate progress this area.Objective: To describe spectrum being detected patients with epilepsy or epileptic encephalopathy clinical practice neurologists specializing an analysis diagnosed syndromes, characteristics seizures, timing a genetic diagnosis, options and treatment efficacy.Methods: The study included 100 (40 boys, 60 girls) epilepsy/epileptic mutation identified....
Purpose. To study the structure of comorbid disorders in children with tycotic hyperkinesis city Tyumen. Materials and methods. We examined 103 aged 5 to 14 years. Patients were divided into 2 groups: group 1 – local tics (n = 43), common 60). All patients received anticitotic therapy. Using various scales questionnaires, an assessment tic hyperkinesis, level anxiety, a rational, emotional behavioral components relationship between parents child, investigation sphere, neuropsychological...
The article describes the peculiarities of a rare disease – hemiplegic migraine in three patients (two boys aged 7 and 15 girl 12 years old). family history was not burdened. Attack symptoms were almost identical: hemiparesis, dysphasia, headache. electroencephalograms, magnetic resonance imaging all presented signs brain dysfunction. Analysis literature data has been carried out. Thediagnostic criteria for migraine, its differential diagnosis is described. considered description increases...
The article describes the peculiarities of a rare disease – hemiplegic migraine in 3 patients (two boy aged 7 and 15 years old girls 12 years). family history was not burdened. Attack symptoms were almost identical: hemiparesis, dysphasia, headache electroencephalograms, magnetic resonance imaging all presented signs brain dysfunction. considered description increases awareness doctors on issue, which is very practice pediatrician neurologist.