Alejandra García-Hernández

ORCID: 0000-0003-4394-3175
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About
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Research Areas
  • MicroRNA in disease regulation
  • Cancer Cells and Metastasis
  • Extracellular vesicles in disease
  • Circular RNAs in diseases
  • Cancer-related molecular mechanisms research
  • Organizational Management and Innovation
  • Angiogenesis and VEGF in Cancer
  • RNA modifications and cancer
  • Phytochemistry and Bioactive Compounds
  • Phytochemistry and biological activities of Ficus species
  • Plant and soil sciences
  • Cancer, Hypoxia, and Metabolism
  • Metabolism, Diabetes, and Cancer
  • Glaucoma and retinal disorders
  • Autophagy in Disease and Therapy
  • Cutaneous Melanoma Detection and Management
  • Connective tissue disorders research
  • Breastfeeding Practices and Influences
  • Soil Science and Environmental Management
  • GABA and Rice Research
  • Phytochemistry and Bioactivity Studies
  • Cancer, Stress, Anesthesia, and Immune Response
  • Essential Oils and Antimicrobial Activity
  • Erythrocyte Function and Pathophysiology
  • Endometrial and Cervical Cancer Treatments

Universidad Autónoma de la Ciudad de México
2023-2024

Center for Research and Advanced Studies of the National Polytechnic Institute
2020-2024

Instituto Politécnico Nacional
2019-2024

Universidad Autónoma de Guerrero
2022

Secretaria de Salud
2022

Universidad Michoacana de San Nicolás de Hidalgo
2014-2018

Institute for Social Security and Services for State Workers
2015

Universitat Politècnica de València
2013

Institute for Management of Innovation and Technology
2013

Hospital Clínic de Barcelona
2013

Tumors have high requirements in terms of nutrients and oxygen. Angiogenesis is the classical mechanism for vessel formation. Tumoral vascularization has function nourishing cancer cells to support tumor growth. Vasculogenic mimicry, a novel intratumoral microcirculation system, alludes ability organize three-dimensional (3D) channel-like architectures. It also supplies tumors with Both mechanisms operate coordinated way; however, their functions breast stem-like regulation by microRNAs...

10.3390/ncrna10010014 article EN cc-by Non-Coding RNA 2024-02-09

Leptin is one of the main adipokines secreted in breast tissue. promotes epithelial–mesenchymal transition (EMT), cell migration and invasion epithelial cells, leading to tumor progression. Although, molecular mechanisms that underlie these events are not fully understood, activation different signaling pathways appears be essential. In this sense, effects leptin on kinases like Src FAK, which regulate activate EMT program, completely described. Therefore, we investigated involvement using...

10.3390/cells8101133 article EN cc-by Cells 2019-09-24

Cross sectional.(a) Is any clinical variable of ankylosing spondylitis (AS) associated with the presence ossification posterior longitudinal ligament (OPLL)? and (b) OPLL present in patients AS from different geographical or genetic backgrounds?Three groups were assembled: (1) a prospective group 103 consecutive two community based rheumatology clinics Guadalajara, who evaluated using: questionnaire disease characteristics variables; assessment by neurologist; lateral radiographic views...

10.1136/ard.57.7.429 article EN Annals of the Rheumatic Diseases 1998-07-01

In recent years, technology has allowed the development of new diagnostic techniques which allow real-time, in vivo, noninvasive evaluation morphological changes tissue. This study compares and correlates images findings obtained by high-definition optical coherence tomography (HD-OCT) reflectance confocal microscopy (RCM) with histology normal healthy oral mucosa. The lip mucosa ten adult volunteers was imaged HD-OCT RCM. Each volunteer systematically evaluated RCM starting uppermost part...

10.1155/2013/205256 article EN cc-by Dermatology Research and Practice 2013-01-01

Abstract Leptin is one of the main adipokines secreted in breast tissue, and has been associated with epithelial-mesenchymal transition (EMT) tumor progression cancer. promotes EMT, cell migration invasion epithelial cells, leading to progression. However, molecular mechanism that underlies these events not fully understood; however, activation different signaling pathways appears be essential. In this sense, effect leptin on kinases like Src FAK, which regulate activate EMT program,...

10.1101/739169 preprint EN cc-by-nc bioRxiv (Cold Spring Harbor Laboratory) 2019-08-18

En este estudio se presentan los resultados de la adaptación a grupos I+D universitarios habla hispanade encuesta sobre cultura organizacional Denison. Este cuestionario, compuesto por 60 ítems que identifican 12 tipos culturales, su vez agrupan en cuatro dimensiones, ha demostrado influencia para aumentar efectividad organizacional. La al castellano aquí propone sido aplicada 488 personas pertenecientes 39 tecnológicos Universidad Politécnica Valencia. Los obtenidos muestran unas...

10.18774/448x.2010.7.109 article ES Summa Psicológica 2013-08-07

Vasculogenic mimicry (VM) is an alternative intratumoral microcirculation system that depends on the capacity of tumor cells to reorganize and grow in three-dimensional (3D) channel architectures like capillaries formed by endothelial cells. Both VM angiogenesis may coordinately function feed cancer cells, allowing growth. Long noncoding RNAs (lncRNAs) regulate critical cellular functions including cell proliferation, apoptosis, angiogenesis, invasion, metastasis. The lncRNA, known as actin...

10.1186/s12885-024-13019-6 article EN cc-by-nc-nd BMC Cancer 2024-10-29

Tumor cells grow in three-dimensional (3D) channels-like structures denoted as vasculogenic mimicry (VM), which provides a route for nutrients and oxygen acquisition. VM is activated by hypoxia associated with metastasis poor prognosis. MetastamiRs are microRNAs regulating metastasis, however, if they control breast cancer remains poorly understood. The aim of this study was to evaluate the expression VM-associated tumors metastatic patients. Firstly, we constructed microRNAs/mRNAs...

10.1016/j.tranon.2023.101680 article EN cc-by-nc-nd Translational Oncology 2023-04-28

En este estudio se presentan los resultados de la adaptacion a grupos I+D universitarios habla hispana encuesta sobre cultura organizacional Denison. Este cuestionario, compuesto por 60 items que identifi can 12 tipos culturales, su vez agrupan en cuatro dimensiones, ha demostrado infl uencia para aumentar efectividad organizacional. La al castellano aqui propone sido aplicada 488 personas pertenecientes 39 tecnologicos Universidad Politecnica Valencia. Los obtenidos muestran unas...

10.18774/summa-vol7.num1-109 article ES DOAJ (DOAJ: Directory of Open Access Journals) 2013-08-01

Abstract Breast cancer is the most frequent neoplasia in developed countries and leading cause of death women worldwide. Epithelial‐to‐mesenchymal transition (EMT) a cellular process through which epithelial cells decrease or lose their characteristics gain mesenchymal properties. EMT mediates tumor progression, because acquire capacity to execute multiple steps invasion metastasis. Benzo[ ]pyrene (B[a]P) an environmental organic pollutant generated during burning fossil fuels, wood, other...

10.1002/mc.23726 article EN Molecular Carcinogenesis 2024-04-17

While epidemiological evidence has long linked obesity with an increased risk of breast cancer, the intricate interactions between adipocytes and cancer cells within tumor microenvironment remain largely uncharted territory. The use organotypic three-dimensional (3D) cell cultures that more accurately mimic spatial architecture tumors represents innovative approach to this complex issue. In present study, we investigated effects on proteome Hs578t cultured in a 3D microenvironment. Using...

10.1038/s41598-024-76053-1 article EN cc-by-nc-nd Scientific Reports 2024-11-07


 El nurité, Satureja macrostema, tiene gran importancia en la medicina tradicional mexicana. presente trabajo evaluó el crecimiento y contenido de compuestos volátiles parte aérea esta especie. efecto fertilización mineral N – P - K se analizó plantas micropropagadas (clones), cultivadas por 90 días invernadero. Se aplicaron tres niveles mensualmente, siguiente manera: T2: 10 10; T3: 17 T4: 20 20, además un tratamiento testigo, T1: 1 g kg-1 sustrato. Las del T4 tuvieron mayor...

10.29298/rmcf.v5i21.362 article ES cc-by-nc Revista mexicana de ciencias forestales 2018-06-14

Triple-negative breast cancer (TNBC) is the most aggressive subtype due to its greater invasive capacity and non-response hormone therapy. Several species of Ficus genus have been used as an alternative traditional medicine against malignant diseases. Previously, leaf extracts from crocata (Miq.) Mart. ex Miq. (F. crocata) showed antiproliferative activity in vitro cervical tumor cells without having a cytotoxic effect on non-tumor cell lines. The purpose study was evaluate hexane (Hex-EFc),...

10.1016/j.heliyon.2022.e11405 article EN cc-by-nc-nd Heliyon 2022-11-01
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