A5100339100- Pediatric Hepatobiliary Diseases and Treatments
- Effects of Radiation Exposure
- Fungal Infections and Studies
- Radiation Therapy and Dosimetry
- Gallbladder and Bile Duct Disorders
- Cardiac tumors and thrombi
- Cancer Risks and Factors
- Venous Thromboembolism Diagnosis and Management
- RNA modifications and cancer
- Liver Diseases and Immunity
- Global Cancer Incidence and Screening
- Nail Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Multiple and Secondary Primary Cancers
- PARP inhibition in cancer therapy
- Inflammatory Biomarkers in Disease Prognosis
- ATP Synthase and ATPases Research
- Genomics and Rare Diseases
- Diet and metabolism studies
- Tuberculosis Research and Epidemiology
- Drug Transport and Resistance Mechanisms
- Plant Pathogens and Fungal Diseases
- Renin-Angiotensin System Studies
- Cancer, Stress, Anesthesia, and Immune Response
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
Zhongda Hospital Southeast University
2023-2024
Tianjin Medical University
2022-2023
Tianjin Children's Hospital
2023
National Institute for Radiological Protection
2016-2023
Seventh People's Hospital of Shanghai
2022
Shanghai University of Traditional Chinese Medicine
2022
Wuhan University of Science and Technology
2021-2022
Xuzhou Children Hospital
2018-2021
Background . Hypercholesterolemia and disruptions of the blood brain barrier (BBB) have been implicated as underlying mechanisms in pathogenesis Alzheimer's disease (AD). Simvastatin therapy may be benefit treating AD; however, its mechanism has not yet fully understood. Objective To explore whether simvastatin could block disruption BBB induced by cholesterol both vivo vitro. Methods New Zealand rabbits were fed cholesterol-enriched diet with or without simvastatin. Total serum was...
Purpose: To evaluate the association of diabetic retinopathy with subclinical atherosclerosis in middle-aged and elderly Chinese type 2 diabetes. Methods: A cross-sectional community-based study was performed among 1607 patients aged 40 years or older Shanghai. Non-mydriatic digital fundus photography examination used detection. Presence elevated carotid intima-media thickness plaque defined as atherosclerosis. Results: The prevalence 15.1% total patients. Patients were more likely to have...
Abstract Background Pathogenic variants of PAX2 cause autosomal-dominant -related disorder, which includes variable phenotypes ranging from renal coloboma syndrome (RCS), congenital anomalies the kidney and urinary tract (CAKUT) to nephrosis. Phenotypic variability makes it difficult define phenotypic spectrum associated with genotype. Methods We collected in patients enrolled China national multicenter registry who were diagnosed pathogenic variant reviewed all published cases disorders....
Abstract Background While the GRIPHON study and others have confirmed efficacy safety of selexipag with single, dual, initial triple combination therapy for patients pulmonary arterial hypertension (PAH), multicenters studies concerning diverse oral therapies based on are limited. Hypothesis This was conducted to evaluate effects various sequential PAH outcomes. Methods A retrospective carried out involving 192 from 10 centers, who were receiving consisting an endothelin receptor antagonist...
Facial seborrheic dermatitis is a chronic skin condition that presents as erythematous scaly and has detrimental effect on the patient's quality of life. The purpose this article to present successful treatment two male patients with face dermatitis, one aged 50 other 56, who developed facial following erythema eruptions. We diagnosed it based patients' initial appearances location during episode. previous doctor symptoms related allergies or infections; therefore, they were treated...
Pulmonary artery intimal sarcoma (PAIS) is a rare malignant tumor that presents with nonspecific symptoms and may be misdiagnosed as thromboembolic disease. We report case of 40-year-old female who presented diarrhea the initial symptom, was received thrombolytic therapy for presumed pulmonary embolism. Progressive subsequent surgery led to diagnosis PAIS, early relapse after endarterectomy. Her survival time 17 months To our knowledge, manifestation PAIS has not been described.
Abstract Purpose The optimal neoadjuvant chemotherapy regimen for early-stage human epidermal growth factor receptor 2(HER2)-positive breast cancer in the context of anti-HER2 therapy is unclear. aim this study was to compare effects anthracycline and non-anthracycline regimens, under different HER2 blocking conditions, on efficacy long-term prognosis HER2-positive cancer. Methods In real-world retrospective observational study, 270 patients treated with stage II-III our center, were...
Objective To explore the cancer incidence and mortality in registration areas of Shanxi Province 2014. Methods The data 12 2014 were taken to analyze characteristics for patients with different age gender areas. And then results compared malignant nationwide. Results There 11 703 new cases, including 6 559 males 5 144 females 2014, rate was 221.21/105, while age-standardized Chinese population world 163.91/105 163.25/105, respectively. The urban 247.02/105 171.35/105. In rural...
Objective To investigate the changes of gene transcriptional profile in human lymphocyte irradiated by heavy ion. Methods The agilent expression microaray was used to detect and analysis profiles lymphoblastoid cells exposed 0.1, 0.5 2 Gy ions 56Fe17+ 12C6+ . The differential expressed genes were analyzed using GO (gene ontology) database, pathway KEGG database. Results Heavy ion irradiation affected expressions cells. transcription levels for101, 199, 299 changed ion,...
Objective To compare the radiation effects of 56Fe17+ , 12C6+ ion beams and 60Co γ-rays on chromosome aberrations, cell cycle arrest apoptosis induction in lymphocytes. Methods Lymphocytes Peng-EBV cells were exposed to ions with different dose (0, 0.5, 2.0 Gy) at rates 0.26-0.55, 0.30-0.50 0.75 Gy/min, respectively. Chromosome aberration d+ r distortion rate was assayed, analyzed by flow cytometry. Results The percentage increased significantly after exposure to12C6+...
Heavy ions are charged particles that have an inverted depth-dose profile because of the so-called Bragg peak. ions(densely ionizing radiation) a higher relative biological effectiveness than photons. This review focused on differences in radiation between heavy and low-linear energy transfer photons at cellular molecular levels. Key words: Heavy ions; Radioation effectiveness; Low linear rays
Objective To explore the cancer incidence in registration areas Shanxi Province. Methods Data of 8 2011 were taken into account and different with ages was compared that other domestic areas. Results 8 395 new cases all sites reported 2011, including 4 810 male 3 585 female. The malignant 207.53/100 000, standardized Chinese population world 125.20/100 000 165.72/100 respectively. In urban areas, 202.49/100 112.81/100 rural rate 211.96/100 138.43/100 000. Province, major for...
Abstract Purpose Aim of this study was to investigate the effectiveness neutrophil, monocyte and lymphocyte HDL- cholesterol ratio in people diagnosed with acute pulmonary embolism for predict related adverse clinical events (PEACE). Methods Retrospective collected date total 215 patients embolism. Laboratory results leukocyte, biochemical cardiac markers were collected. Pulmonary Embolism Severity Index (PESI), count high-density lipoprotein (HDL) calculated. SPSS 25 used evaluating NHR MHR...
Abstract Background: Biliary Atresia (BA) is a devastating pediatric cholangiopathy affecting the bile ducts of liver. Current research has found variety causes for BA, with inflammation and fibrosis more studied. However, these etiological mechanisms are not present in all patients. Pyroptosis been increasingly appreciated as programmed cell death process but less studied BA. We have re-classified BA by integrating gene microarray data scRNA-seq to support individualized clinical treatment...