A5067693682- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Receptor Mechanisms and Signaling
- Hormonal and reproductive studies
- Pharmacogenetics and Drug Metabolism
- Genetics, Aging, and Longevity in Model Organisms
Washington State University
2022-2023
Abstract In sexual reproduction, sperm contribute half the genomic material required for creation of offspring yet core molecular mechanisms essential their formation are undefined. Here, α-arrestin molecule arrestin-domain containing 5 (ARRDC5) is identified as an regulator mammalian spermatogenesis. Multispecies testicular tissue transcriptome profiling indicates that expression Arrdc5 testis enriched, if not specific, in mice, pigs, cattle, and humans. Knockout mice leads to male specific...
Abstract In sexually reproducing organisms, sperm contribute half the genomic material required for creation of offspring and natural fertility relies on males producing millions by way spermatogenesis. This process is essential continuity diversity a species, yet evolutionarily conserved core molecular regulators are undefined. Here we used single cell RNA-sequencing testicular tissue from mice, pigs, cattle to generate multispecies integrated transcriptome database. Through bioinformatic...