A5038315249- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Hemoglobin structure and function
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroscience of respiration and sleep
- Calcium signaling and nucleotide metabolism
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- DNA Repair Mechanisms
- Metabolism and Genetic Disorders
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Maternal and Perinatal Health Interventions
- ATP Synthase and ATPases Research
- Pharmacogenetics and Drug Metabolism
Sardar Patel Medical College
2020
University of Pennsylvania
2012-2017
The University of Texas Medical Branch at Galveston
2012-2014
RWTH Aachen University
2009-2010
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxic side product formed in the chemical synthesis of desmethylprodine opioid analgesic, which induces Parkinson disease. Monoamine oxidase B, present mitochondrial outer membrane glial cells, catalyzes oxidation MPTP to toxic 1-methyl-4-phenylpyridinium ion (MPP(+)), then targets dopaminergic neurons causing neuronal death. Here, we demonstrate that mitochondrion-targeted human cytochrome P450 2D6 (CYP2D6), supported by...
Abstract Astrocyte mitochondria play an important role for energy supply and neuronal survival in the brain. Toxic degenerative processes are largely associated with mitochondrial dysfunction. We, therefore, investigated effect of 3‐nitropropionic acid (NPA), a toxin vitro model Huntington's disease (HD), on function viability primary striatal astrocytes. Although NPA is known as irreversible inhibitor succinate dehydrogenase, we observed increase astrocyte ATP levels after treatment. This...
A number of xenobiotic‐inducible cytochrome P450s (CYPs) are now known to be localized in the mitochondrial compartment, though their pharmacological or toxicological roles remain unclear. Here, we show that BNF treatment markedly inhibits liver O 2 consumption rate (OCR), ADP‐dependent OCR, and also reserve wild‐type mice but not Cyp1a1/1a2(−/−) double knockout mice. affected complex I IV activities attenuated gene expression. Furthermore, under vitro conditions, induced cellular ROS...
Acute inhalation of combustion smoke adversely affects brain homeostasis and energy metabolism. We previously showed that overexpressed neuroglobin (Ngb), neuron specific globin protein, attenuates the formation inhalation-induced oxidative DNA damage, in vivo, mouse brain, while others reported protection by Ngb diverse models injury, mainly involving stress hypoxic/ischemic insults.To determine to what extent elevated ameliorates post smoke-inhalation bioenergetics overexpressing...
Background: The present study aims to compare the results of EASI followed by oral misoprostol and alone for induction labour in pregnancies more than 28 weeks with intrauterine foetal death.
 Methods: observational prospective is an attempt efficacy extra-amniotic saline instillation Foley catheter prior fetal Results: Most cases delivered vaginally both groups. mean delivery time group I was higher II were statistically significant on comparing In I, 78% within 24 hours whereas 96%...