Abstract Simulating nature and in particular processes particle physics require expensive computations sometimes would take much longer than scientists can afford. Here, we explore ways to a solution for this problem by investigating recent advances generative modeling present study the generation of events from physical process with deep models. The simulation requires not only production events, but also ensure that these occur correct frequencies. We investigate feasibility learning event...

Combined radiotherapy and hyperthermia is a well-established alternative to chemoradiotherapy for advanced stage cervical cancer patients with contraindication chemotherapy. Pre-clinical evidence suggests that the radiosensitizing effect of decreases substantially time intervals between as short 1-2 h, but clinical limited. The purpose this study determine interval external beam (EBRT) same-day on in-field recurrence rate, overall survival late toxicity in women cancer.Patients who underwent...

Human papillomavirus (HPV) is associated with cervical cancer, the third most common cancer in women. The high-risk HPV types 16 and 18 are found over 70% of cancers produce oncoprotein, early protein 6 (E6), which binds to p53 mediates its ubiquitination degradation. Targeting E6 has been shown be a promising treatment option eliminate HPV-positive tumor cells. In addition, combined hyperthermia radiation very effective strategy for cancer. this study, we examined effect on cells using cell...

We present a study for the generation of events from physical process with deep generative models. The simulation processes requires not only production events, but also to ensure these occur correct frequencies. investigate feasibility learning event and frequency occurrence Generative Adversarial Networks (GANs) Variational Autoencoders (VAEs) produce like Monte Carlo generators. three processes: simple two-body decay, $e^+e^-\to Z \to l^+l^-$ $p p t\bar{t} $ including decay top quarks...

Locoregional hyperthermia combined with radiotherapy significantly improves locoregional control and overall survival for cervical tumors compared to alone. In this study biological modelling is applied quantify the effect of radiosensitization three cancer patients evaluate improvement in equivalent dose combination treatment hyperthermia. The Linear-Quadratic (LQ) model extended temperature-dependent LQ-parameters α β was used by calculate conventional radiation that treatment. External...

The next generation gravitational wave interferometric detectors will likely be underground to extend the GW detection frequency band frequencies below Newtonian noise limit. originates from continuous motion of Earth's crust driven by human activity, tidal stresses and seismic motion, mass density fluctuations in atmosphere. It is calculated that on surface, a typical day, it exceed expected signals at 10 Hz. decrease an unknown amount. important investigate quantify this reduction its...

Purpose: Biological modelling of thermoradiotherapy may further improve patient selection and treatment plan optimisation, but requires a model that describes the biological effect as function variables affect outcome (e.g. temperature, radiation dose). This study aimed to establish such its parameters. Additionally, clinical example was presented illustrate application.Methods: Cell survival assays were performed at various combinations dose (0–8 Gy), temperature (37–42 °C), time interval...

Currently, clinical decisions regarding thermoradiotherapy treatments are based on experience. Quantification of the radiosensitising effect hyperthermia allows comparison different treatment strategies, and can support decision-making optimal treatment. The software presented here enables biological evaluation plans through calculation equivalent 3D dose distributions.Our in-house developed (X-Term) uses an extended version linear-quadratic model to calculate radiation dose, i.e. yielding...

Cervical cancers are almost exclusively caused by an infection with the human papillomavirus (HPV). When patients suffering from cervical cancer have contraindications for chemoradiotherapy, radiotherapy combined hyperthermia is a good treatment option. Radiation-induced DNA breaks can be repaired nonhomologous end-joining (NHEJ) or homologous recombination (HR). Hyperthermia temporarily inactivate recombination. Therefore, combining result in persistence of more fatal radiation-induced...

Purpose: Thermoradiotherapy is an effective treatment for locally advanced cervical cancer. However, the optimal time interval between radiotherapy and hyperthermia, resulting in highest therapeutic gain, remains unclear. This study aims to evaluate effect of on gain using biological planning.Methods: Radiotherapy hyperthermia plans were created 15 cancer patients. Biological modeling was used calculate equivalent radiation dose, that is, dose results same as thermoradiotherapy treatment,...

// Arlene L. Oei 1, 2 , Caspar M. van Leeuwen Vidhula R. Ahire Hans Rodermond Rosemarie ten Cate Anneke Westermann 3 Lukas J.A. Stalpers Johannes Crezee H. Petra Kok Przemek Krawczyk 4 Roland Kanaar 5, 6 Nicolaas A.P. Franken 1 Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center Molecular Medicine, Academic Medical (AMC), Amsterdam, The Netherlands Department of Radiotherapy, Oncology, Cell Biology Histology, Center, 5 Genetics, Cancer Genomics Netherlands, Utrecht,...

Cis-diamminedichloroplatinum(II) (cisplatin, cDDP) is an effective chemotherapeutic agent that induces DNA double strand breaks (DSBs), primarily in replicating cells. Generally, such DSBs can be repaired by the classical or backup non-homologous end joining (c-NHEJ/b-NHEJ) homologous recombination (HR). Therefore, inhibiting these pathways cancer cells should enhance efficiency of cDDP treatments. Indeed, inhibition HR hyperthermia (HT) sensitizes to and Netherlands this combination a...

Poly(ADP-ribose)polymerase1 (PARP1) is an important enzyme in regulating DNA replication. Inhibition of PARP1 can lead to collapsed forks which subsequently causes genomic instability, making more susceptible developing fatal double strand breaks. PARP1-induced damage generally repaired by homologous recombination (HR), BRCA2 proteins are essential. Therefore, BRCA2-deficient tumour cells treatment with PARP1-inhibitors (PARP1-i). Recently, was shown be down-regulated hyperthermia (HT)...

Abstract. Atmospheric boundary layers and other wall-bounded flows are often simulated with the large-eddy simulation (LES) technique, which relies on subgrid-scale (SGS) models to parameterize smallest scales. These SGS make strong simplifying assumptions. Also, they tend interact discretization errors introduced by popular LES approach where a staggered finite-volume grid acts as an implicit filter. We therefore developed alternative model based artificial neural networks (ANNs) for...

The radiative transfer equations are well-known, but radiation parametrizations in atmospheric models computationally expensive. A promising tool for accelerating is the use of machine learning techniques. In this study, we develop a learning-based parametrization gaseous optical properties by training neural networks to emulate modern parameterization (RRTMGP). To minimize computational costs, reduce range conditions which applicable and machine-specific optimised BLAS functions accelerate...

<p>A fast and accurate treatment of radiation in meteorological models is essential for high quality simulations the atmosphere. Despite our good understanding processes governing transfer radiation, full radiative solvers are computationally extremely expensive. In this study, we use machine learning to accelerate optical properties calculations Rapid Radiative Transfer Models General circulation model applications - Parallel (RRTMGP). These control absorption, scattering...

Abstract Getting scientific software installed correctly and ensuring it performs well has been a ubiquitous problem for several decades now, which is compounded currently by the changing landscape of computational science with (re‐)emergence different microprocessor families, expansion to additional domains like artificial intelligence next‐generation sequencing. The European Environment Scientific Software Installations (EESSI) project aims provide ready‐to‐use stack installations that can...