A5032607545- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- Youth Substance Use and School Attendance
- Diagnosis and treatment of tuberculosis
- RNA modifications and cancer
- Neutropenia and Cancer Infections
- Cardiac, Anesthesia and Surgical Outcomes
- Tuberculosis Research and Epidemiology
- Drug Transport and Resistance Mechanisms
- COVID-19 Clinical Research Studies
- Aortic aneurysm repair treatments
- Polyomavirus and related diseases
- Biochemical and Molecular Research
- Nutrition, Genetics, and Disease
- BRCA gene mutations in cancer
- Peripheral Artery Disease Management
- Ubiquitin and proteasome pathways
- Delphi Technique in Research
- Artificial Intelligence in Healthcare and Education
- Chronic Lymphocytic Leukemia Research
University of Oxford
2018-2025
Science Oxford
2025
Oxford Spires Academy
2024
CRUK/MRC Oxford Institute for Radiation Oncology
2018-2021
Medical Research Council
2019-2021
Cancer Research UK
2020
Abstract Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate—a covalent TOP1-DNA adduct known as cleavage complex (TOP1cc)—is stabilised. TOP1ccs are highly cytotoxic failure resolve them underlies the pathology neurological disorders but exploited in cancer therapy where target widely used frontline anti-cancer drugs. A critical...
To assess the benefits and drawbacks of school closures in-school mitigations during COVID-19 pandemic.Overview systematic reviews (SRs).We searched six databases additional resources on 29 July 2022: MEDLINE, Embase, Google Scholar, Cochrane Library, COVID-END inventory evidence synthesis, Epistemonikos.We selected SRs written in English that answered at least one four specific questions concerning efficacy closures. Their primary studies were conducted secondary schools, including pupils...
Efficient entry into S phase of the cell cycle is necessary for embryonic development and tissue homoeostasis. However, unscheduled triggers DNA damage promotes oncogenesis, underlining requirement strict control. Here, we identify NUCKS1-SKP2-p21/p27 axis as a checkpoint pathway G1/S transition. In response to mitogenic stimulation, NUCKS1, transcription factor, recruited chromatin activate expression SKP2, F-box component SCF
Article19 August 2019Open Access Transparent process E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin loss and Chk1 inhibition Kamila Burdova Department of Oncology, Medical Research Council Institute for Radiation University Oxford, UK Search more papers by this author Hongbin Yang Roberta Faedda Samuel Hume Jagat Chauhan Nuffield Clinical Medicine, Ludwig Cancer Research, Headington, Daniel Ebner Target Discovery Institute, Benedikt M Kessler Iolanda Vendrell...
To deliver efficacious personalised cancer treatment, it is essential to characterise the cellular metabolism as well genetic stability of individual tumours. In this study, we describe a new axis between DNA repair and detoxification aldehyde derivatives with important implications for patient prognosis treatment.
Abstract Efficient entry into S phase of the cell cycle is necessary for embryonic development and tissue homeostasis. However, unscheduled triggers DNA damage promotes oncogenesis, underlining requirement strict control. Here, we identify NUCKS1-SKP2-p21/p27 axis as a checkpoint pathway G1/S transition. In response to mitogenic stimulation, NUCKS1, transcription factor, recruited chromatin activate expression SKP2 , F-box component SCF ubiquitin ligase, leading degradation p21 p27 promoting...
Summary Cyclins are central engines of cell cycle progression when partnered with Cyclin Dependent Kinases (CDKs). Among the different cyclins controlling progression, cyclin F does not partner a CDK, but forms an E3 ubiquitin ligase, assembling through F-box domain, Skp1-Cul1-F-box (SCF) module. Although multiple substrates have been identified vulnerabilities cells lacking known. Thus, we assessed viability upon challenging more than 200 kinase inhibitors. The screen revealed striking...