Objective. To study the dynamics of changes in indicators biochemical blood analysis and markers state hemostasis fibrinolysis systems patients with previously treated bronchial asthma (BA) moderate severity who had did not have COVID-19 before during treatment. Material methods. The included 58 were divided into two groups: 1st (BA/COVID-19; n=29) – BA undergone COVID-19; 2st (BA; COVID-19. Markers impaired liver function, lipid metabolism, as well a marker systemic inflammation, C-reactive...

Pulmonary tuberculosis and malignant neoplasms (MNs) are important global healthcare issues. There has been a large number of studies on the relationship between pulmonary MNs, but comprehensive approaches to diagnosis treatment these diseases need be developed implemented. Objective. To study at current stage phthisiology. Materials methods. Analysis domestic foreign databases for period from 1976 2024 was performed. The following keywords were used search literature: «tuberculosis»,...

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Currently, according to the World Health Organization, targets for effectiveness of treatment patients with pulmonary tuberculosis do not achieve their goals. In this regard, it is urgent search optimal integrated approaches in tuberculosis. The aim work demonstrate high use methods collapse therapy and CBB complex a patient widespread process. Materials . analysis patient’s medical documentation was carried out, data anamnesis disease, X-ray archive, clinical, laboratory instrumental...

216 new pulmonary tuberculosis patients suffering from multiple drug resistance (MDR) were examined. The divided into 2 groups. first group consisted of 164 in whom when admitted to hospital, GeneXpert MTB/RIF was used test the Mycobacterium (MTB) rifampicin. Initially, this treated with chemotherapy regimen 4 (pyrazinamide, kanamycin/amikacin/capreomycin, fluoroquinolones, cycloserine/terizidone, prothionamide, PAS). Group included 97 patients. They all 1 (isoniazid, rifampicin,...

The level of uric acid in blood serum was investigated 134 new patients suffering from multiple drug resistant pulmonary tuberculosis (78 men and 56 women). tests were performed by admission to hospital then repeated 1, 2, 3, 4, 5, 6, 7 8 months treatment. Prior chemotherapy the increased observed 28.2% 37.5% women. During treatment with pyrazinamide this category 1 month after start further it went down; however above normal during whole course Monitoring initially rates has shown that...

This review provides new literature data on the features of changes in indicators clinical and biochemical analysis blood, as well hemostatic fib-rinolysis systems patients with coronavirus infection COVID-19. It was shown that laboratory manifestations COVID-19 have their own characteristics are closely interrelated nature course infection. In a blood test, lymphopenia thrombocytopenia most common. Among bio-chemical parameters an increase level C-reactive protein ferritin, decrease...

238 tuberculosis cases with concurrent HIV infection were examined. The age of patients varied from 24 to 57 years old. Men made 189 (79.4%), and women 49 (20.6%). CD4 count in the examined 0 1.216 × 10 9 /L. intensity systematic inflammatory response was evaluated as per rates acute phase reactants: С-reactive protein (СRP), α 1 -antitrypsin (α -АТ), haptoglobin (HG) fibrinogen (F). It found out that demonstrated confidently increased levels C-reactive protein, -antitrypsin, haptoglobin,...

The objective: to study the quantity and variability of bacterial microbiota in lower gut, prevalence microorganisms resistant antibacterial drugs among isolated from bronchi pulmonary tuberculosis patients receiving chemotherapy. Subjects methods . Microorganisms gastrointestinal tract respiratory were studied. 178 examined retrospectively 53 prospectively. Diagnostic specimens obtained bronch i/l ungs (sputum, bronchoalveolar lavage fluid, aspirate, etc.) tested. Bacteriological tests...

One of the complications tuberculosis process is tracheobronchial tree, which tends to grow in recent years. Many studies indicate incidence bronchial from 10% 40%, taking into account level diagnostic measures detect and availability endoscopic services. An important problem treatment psychological problems patients, including those with drug-resistant tuberculosis. In phthisiology, attention drawn widespread history stress patients complexity rehabilitation against background treatment....

Introduction. According to the World Health Organization data for 2021, there is an increase in incidence of tuberculosis (TB) worldwide. There also unfavorable growth trend drug-resistant TB. One complications process tracheobronchial tree, which has tended grow recent years. Many studiesindicate bronchial from 10 40 %, taking into account level endoscopic service. The purpose study demonstrate high effectiveness integrated approach treatment a patient with lungs and tree. Methods. materials...

Introduction . One of the problems domestic phthisiology is low effectiveness treatment, which, along with anti-tuberculosis chemotherapy, uses pathogenetic methods, including physiotherapy procedures. The use several physical factors in treatment pulmonary tuberculosis shows great therapeutic effectiveness. However, there are not enough works highlighting combined effects respiratory system, applied successive courses, taking into account phase a specific process and mechanisms methods. T...

To improve treatment effectiveness in TB cases is the priority goal of global and domestic phthisiology. achieve this goal, we have to overcome such challenges as a high share drug resistance significant prevalence comorbidities. Diabetes mellitus (DM) one most common non-infectious diseases, which burdens course contributes development various adverse reactions drugs eventually resulting lower treatment. We represent clinical observations demonstrating individualized approach administration...

Objective: to evaluate safety and effectiveness of TB treatment regimen containing bedaquiline, pretomanid, moxifloxacin, pyrazinamide (BPaMZ) in drug-sensitive multidrug-resistant pulmonary patients. Materials methods. The study enrolled 12 patients who received at the Central Research Institute 2019–2020, including 7 drug-resistant patients, completed a six-month with BPaMZ, 5 patients: three BPaMZ for 4 months two isoniazid, rifampicin, pyrazinamide, ethambutol (HRZE) 6 months. Results....

Introduction . There is evidence that smoking affects the course and effectiveness of treatment patients with pulmonary tuberculosis. At same time, tobacco tuberculosis are significant risk factors in development functional lung disorders. The purpose study to nature changes spirometry parameters peculiarities process patients. Materials methods A retrospective cohort study, which included 102 were divided into two groups: 1 — (47 people), 2 non-smoking (55 people). Results It shown men...

45 pulmonary tuberculosis patients with concurrent type 1 diabetes, 69 2 diabetes and 131 without (control group) were examined. The intensity of the system inflammatory response syndrome was evaluated by markers acute inflammation phase – blood levels C-reactive protein (CRP), serum amyloid A (SAA), α1 -antitrypsin (α1 -АТ), haptoglobin, fibrinogen. Nutritional status assessed body mass index (BMI) concentration total (TP), albumin (A), transthyretin (TTR). It found out that in new...

Ретроспективный анализ особенностей течения туберкулеза у пациентов (n=830), умерших от прогрессирования специфического процесса, показал, что туберкулез часто сочетался с сахарным диабетом (n=102), и ВИЧ-инфекцией

Objective. To study in a comparative aspect the level of markers state hemostasis and fibrinolysis systems, indicators clinical blood analysis C-reactive protein (CRP) patients with chronic obstructive pulmonary disease (COPD) severe extremely severity, who underwent did not undergo infection caused by SARS-CoV-2. Material methods. A prospective cohort 56 COPD acute stage. Patients were divided into 2 groups: 1st (n=28) – SARS-CoV-2 infection; 2nd without infection. The CRP evaluated....

Background . Despite the visible successes of domestic phthisiology at present time, problem medical rehabilitation patients with tuberculosis remains relevant. In recent years, approaches to various diseases have changed significantly, which entail need consider a complex measures for from perspective Procedures organizing in adults and children their integration into phthisiatric practice. The aim To study organizational aspects respiratory world Russian Federation. Methods We carried out...

Background. It is known that COVID-19 can be followed by a shift in the hemostatic system towards hypercoagulation, which more pronounced presence of diabetes mellitus (DM). Tuberculosis process often accompanied with hypercoagulation syndrome. Of great interest study state systems patients pulmonary tuberculosis (TB) concomitant DM who have had COVID-19.The aim. To relationship between and fibrinolysis moderate severe mellitus.Methods. 32 TB were divided into two groups. Group 1 included 16...

The article describes a unique clinical case of 18-year comprehensive treatment the patient with disseminated fibrous cavernous pulmonary tuberculosis extensive drug resistance, continuous bacterial excretion and severe concomitant pathology resulting in successful cure tuberculosis. It demonstrates complexity decision-making on management tactics as well rare example exceptional adherence to treatment.