A5070116895- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Functional Brain Connectivity Studies
- Rough Sets and Fuzzy Logic
- Cognitive Computing and Networks
- Transcranial Magnetic Stimulation Studies
- Advanced MRI Techniques and Applications
- Cognitive Science and Mapping
Case Western Reserve University
2017-2020
University of Kansas
2017
Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels the cell and is major control point for modulating gene expression. In yeast other model organisms, codon identity powerful determinant of stability, contributing broadly to impact half-lives. General principles governing mRNA stability are poorly understood mammalian systems. Importantly, however, machinery highly conserved, thus it seems logical that half-lives would also be strongly influenced by coding...
Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels eukaryotic cells. Previous work by us and others has shown that codon identity exerts powerful influence on mRNA stability. In Saccharomyces cerevisiae, studies using handful of reporter mRNAs show optimal codons increase translation elongation rate, which turn increases However, direct relationship between rate stability not been established across the entire yeast transcriptome. addition, there is...
mRNA degradation is a critical, yet poorly understood, aspect of gene expression. Previous studies demonstrate that codon content acts as major determinant stability in model organisms. In humans, the importance open reading frame (ORF)-mediated regulation remains unclear. Here, we globally analyzed for both endogenous and human ORFeome collection mRNAs cells. Consistent with previous studies, observed synonymous usage impacts decay. Unexpectedly, amino acid identity also driver...
A critical aspect of conceptual knowledge is the selective activation goal-relevant aspects meaning. Although contributions ventrolateral prefrontal and posterior temporal areas to semantic cognition are well established, precise role parietal cortex in control remains unknown. Here, we examined whether this region modulates attention features within memory according same principles that determine salience task-relevant object properties during visual attention. Using multivoxel pattern...
mRNA degradation is a critical, yet poorly understood, aspect of gene expression. Previ-ous studies demonstrate that codon content acts as major determinant stabil-ity in model organisms. In humans, the importance open reading frame (ORF)-mediated regulation remains unclear. Here, we globally analyzed stability for both endogenous and human ORFeome collection mRNAs cells. Consistent with previous studies, observed synonymous usage impacts decay. Unexpectedly, amino acid identity also driver...
Abstract Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels eukaryotic cells. Previous work by us and others has shown that codon identity exerts powerful influence on mRNA stability. In Saccharomyces cerevisiae , studies using handful of reporter mRNAs show optimal codons increase translation elongation rate, which turn However, direct link between rate stability not been established across the entire yeast transcriptome. addition, there is evidence from...