Although intraperitoneal chemotherapy (IPC) has been suggested as a promising method for the management of peritoneal dissemination (PD) ovarian or colorectal cancers, actual clinical use this restricted due to such problems poor drug penetration into tumor and high side effects. It is, therefore, necessary develop new strategies improve efficacy approach. In present work, strategy is proposed based on (IP) injection thermosensitive liposomal doxorubicin (TSL-Dox) with triggered release by...

Aim: In this study, the main goal was to apply a multi-scale computational model in evaluating nano-sized drug-delivery systems, following extracellular drug release, into solid tumors order predict treatment efficacy. Methods: The impact of several parameters related tumor (size, shape, vessel-wall pore size, and necrotic core size) therapeutic agents (size nanoparticles, binding affinity drug, release rate from nanoparticles) are examined detail. Results: This study illustrates that...

Intraperitoneal (IP) chemotherapy has emerged as a promising method for the treatment of peritoneal malignancies (PMs). However, microenvironmental barriers in tumor limit delivery drug particles and their deep penetration into tumor, leading to reduced efficiency treatment. Therefore, new systems should be developed overcome these barriers. One technique is magnetically controlled targeting (MCDT) which an external magnetic field utilized concentrate drug-coated nanoparticles (MNPs) desired...

Abstract Heat transfer and friction factor in a tube with turbulator internally grooved rib are studied using numerical simulation. Two different geometries, including only groove both rib, on the wall investigated. The study is developed for parameters of pitch ratio (PR), height (DR), Reynolds number range 10 000 to 38 000. results revealed that best Nusselt achieved GR PR = 2 DR 1. Furthermore, specific parameter, improved by 46% compared experimental result. show decreases increase step...

A new mathematical model of the dressing grinding wheels by diamond disc dresser is developed. It predicts forces between grits a rotating and an alumina wheel. This based on fracture grits, bond contact grits. considers kinematical influences in particular speed ratio process. Also Weibull distribution was used to predict probability fracture. Dressing are measured experimentally compared with those calculated from model. Theoretical results closely match experimental findings. The...

Fire and explosion are the most prevalent accidents in chemical process industries. Hence, identification of hazard factors methods controlling these two major very important In this paper, fire hazards some units at a combined cycle power plant have been estimated using Dow index. The results study show that methane fueled turbine has highest value index which is 321, unit with gas oil storage site values 147.5 35.5 respectively. loss control credit factor for was 0.36 Actual Maximum...

In this paper, thermo-hydraulic analysis of a diamond-shaped turbulator in tube was investigated using the numerical simulation. Nusselt number and friction factor were evaluated by variation Reynolds range 3500–16 500 parameters including step ratio rode diameter. Numerical validation performed with experimental model good matching observed. Then, closed form correlations for presented respect to number. results revealed that =1 rod diameter = 3 mm provide best addition, showed reduces...

The philosophy behind the creation of every organization is bound up with objectives for each it has been created. There are always factors threatening continuation organization’s activities or even its existence. Some these involve common threats in security area which should be identified, assessed and controlled through a systematic risk management pattern. In present study, Security Vulnerability Assessment (SVA) technique local version SVA-Pro software called Joshan-Pro was used to...

In recent years, the use of absorption chillers in air conditioning applications has increased favor less power consumption. Due to fact that require much compared other common devices industry, extensive efforts have been made order model, design, and optimize these systems. This study investigated effect using solar energy on parallel series two-stage refrigeration First, both systems were designed, then by connecting collector equipment system, COP system fuel consumption was calculated....

The final surface topography generated on a grinding wheel is influenced and determined by the dressing conditions. In this paper new mathematical model of wheels diamond disc dresser developed. It predicts components forces between grits rotating an alumina wheel. Dressing parameters were varied are measured experimentally compared with theoretical calculation. Theoretical results closely match experimental findings. Also specific energy at different conditions experimentally. effect...

Intraperitoneal (IP) chemotherapy is a promising treatment approach for patients diagnosed with peritoneal carcinomatosis, allowing the direct delivery of therapeutic agents to tumor site within abdominal cavity. Nevertheless, limited drug penetration into remains primary drawback this method. The process delivering drugs entails numerous complications, primarily stemming from specific pathophysiology tumor. Investigating during IP and studying parameters affecting it are challenging due...