A5011756506- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Cardiac Health and Mental Health
- Platelet Disorders and Treatments
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- ECG Monitoring and Analysis
- Cardiovascular Disease and Adiposity
- Systemic Sclerosis and Related Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Corporate Finance and Governance
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
Charles University
2004-2021
General University Hospital in Prague
2019-2021
Masaryk University
2016
University Hospital Kralovske Vinohrady
2016
St. Anne's University Hospital Brno
2016
University Hospital Brno
2016
Background: No randomized head-to-head comparison of the efficacy and safety ticagrelor prasugrel has been published in 7 years since higher these newer P2Y 12 inhibitors were first demonstrated relative to clopidogrel. Methods: This academic study was designed compare acute myocardial infarction treated with primary or immediate percutaneous coronary intervention. A total 1230 patients randomly assigned across 14 sites either ticagrelor, which initiated before Nearly 4% cardiogenic shock,...
Early outcomes of patients in the PRAGUE-18 (Comparison Prasugrel and Ticagrelor Treatment Acute Myocardial Infarction) study did not find any significant differences between 2 potent P2Y12 inhibitors.The 1-year follow-up focused on: 1) a comparison efficacy safety prasugrel ticagrelor; 2) risk major ischemic events related to an economically motivated post-discharge switch clopidogrel.A total 1,230 with acute myocardial infarction (MI) treated primary percutaneous coronary intervention were...
To compare two different clopidogrel regimens on the outcomes of patients undergoing elective coronary angiography (CAG)±ad hoc percutaneous intervention (PCI). Open-trial randomized 1028 with stable angina to group A ('non-selective'—clopidogrel 600 mg >6 h before CAG; n = 513) or B ('selective'—clopidogrel in cath-lab after CAG, only case PCI; 515). Combined primary endpoint was death/periprocedural myocardial infarction (MI)/stroke/re-intervention within 7 days. Secondary endpoints were...
Purpose: The aim was to identify factors that influence the efficacy of 600 mg clopidogrel pretreatment in patients with stable coronary artery disease undergoing elective percutaneous intervention. Methods: In a laboratory substudy PRAGUE-8 trial, influences nonmodifiable (age and sex) modifiable (body mass index tobacco smoke) factors, comorbidity (hypertension, hyperlipidemia, diabetes mellitus, renal insufficiency) cotherapy (statin, aspirin, heparin), on course were investigated 105...
Operations in the pleural cavity are connected with circulatory changes pulmonary circulation and general of hemodynamics. These influenced by position patient’s body on operation table introduction artificial pneumothorax. Thoracoscopy is an advanced surgical approach thoracic surgery, but its hemodynamic effect still not known. The aim present study was to compare response surgeries carried out open (thoracotomy – TT) closed (thoracoscopy TS) approach. Thirty-eight patients have been...
Purpose: To investigate the prognostic significance of diabetes mellitus (DM) in patients with high risk acute myocardial infarction (AMI) treated primary percutaneous coronary intervention (pPCI) era potent antithrombotics. Methods: Data from 1230 ST-segment elevation (STEMI) enrolled PRAGUE-18 (prasugrel vs. ticagrelor pPCI) study were analyzed. Ischemic and bleeding event rates calculated for without diabetes. The independent impact on outcomes was evaluated after adjustment outcome...
The study aimed to assess the impact of nine polymorphisms genes encoding platelet receptors, enzymes, and hemostatic factors on clopidogrel efficacy inhibit reactivity in patients with stable coronary artery disease undergoing elective angiography either or without ad hoc percutaneous intervention. was performed as a genetic substudy PRAGUE-8 trial. Ninety-five pretreated 600 mg at least 6 h prior were tested. Baseline ADP assessed before drug administered. Clopidogrel tested again 12 28...
Abstract Background Time delay is an important prognostic factor and indicator of quality care for patients with AMI indicated primary percutaneous coronary intervention (PCI). Purpose Assessment total ischaemia time its relationship to catheterization findings the incidence ischaemic events within 1 year in treated PCI. Method The analysis included 1230 AIM PCI randomized Prague-18 study (prasugrel vs. ticagrelor). We evaluated two intermediate intervals: A - from symptom onset arrival...
Abstract Background Antithrombotic therapy is effective in preventing ischemic and thromboembolic events, however it simultaneously increases the risk of bleeding. The efforts thus focus on balancing intensity combined antiplatelet anticoagulant therapy. Purpose study aimed to compare efficacy safety single (aspirin/clopidogrel) or dual (aspirin plus clopidogrel) combination with an oral non-selected patient population atrial fibrillation (AFib) acute coronary syndrome (ACS). Methods...
Abstract Background Early reperfusion of the infarct related artery is only treatment improving prognosis patients with initial cardiogenic shock (CGS) complicated acute myocardial infarction (AMI) (Killip class IV at admission). Purpose The analysis focused on subgroup CGS randomized into multicenter PRAGUE-18 study (prasugrel vs. ticagrelor in primary PCI). Methods In study, (n=1230) treated percutaneous coronary intervention (pPCI) were immediately to prasugrel or intended duration 12...
Abstract Background The left circumflex artery (LCX) and its branches are less often recognized as infarct related (IRA) in STEMI compared to NSTEMI patients because of lower ability detect posterior AMI on 12leads ECG. Significant proportion with acute LCX occlusion therefore did not receive immediate reperfusion therapy. recent ESC guidelines recommendation coronary angiography for ongoing ischemia should change the situation. Objectives To estimate receiving therapy within last 20 years....
Drug-eluting stents (DES) are the recommended for primary percutaneous coronary intervention (PCI). This study aimed to determine why interventional cardiologists used non-DES and how it influenced patient prognoses. The efficacy safety outcomes of different were also compared in patients treated with either prasugrel or ticagrelor. Of PRAGUE-18 patients, 749 (67.4%) DES, 296 (26.6%) bare-metal (BMS), 66 (5.9%) bioabsorbable vascular scaffold/stents (BVS) between 2013 2016. Cardiogenic shock...
Abstract Background Drug-eluting stents (DESs) are the recommended choice of for primary PCI. Purpose/Methods The study aimed to determine why interventional cardiologists used non-DESs and how they had influenced patient prognosis. efficacy safety outcomes different were also compared in treated with either prasugrel or ticagrelor. Results Of PRAGUE 18 patients, 749 (67.4%) DESs, 296 (26.6%) BMS, 66 (5.9%) BVS. Cardiogenic shock at presentation left main disease, especially as culprit...