A5042331278- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Mechanical Circulatory Support Devices
- Hip and Femur Fractures
- Cardiovascular Issues in Pregnancy
- Heme Oxygenase-1 and Carbon Monoxide
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Blood transfusion and management
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Blood donation and transfusion practices
- Complement system in diseases
- Pelvic and Acetabular Injuries
- Central Venous Catheters and Hemodialysis
- Angiogenesis and VEGF in Cancer
- Neonatal Health and Biochemistry
- Electroconvulsive Therapy Studies
Nazarbayev University
2025
Charles University
2009-2023
General University Hospital in Prague
2007-2022
Surgery for benign disease is associated with a low-risk of developing venous thromboembolism (VTE). Despite relatively low incidence postoperative VTE in patients after elective cholecystectomy and abdominal hernia repair there are data proving hypercoagulability the early period. We focused on assessment systemic inflammatory response coagulation status these surgical hospital discharge.Prospectively, who underwent surgery were included. Two hundred sixteen enrolled - 90 laparoscopic (LC)...
Oxidative stress and inflammation contribute significantly to atherogenesis. We others have demonstrated that mildly elevated serum bilirubin levels protect against coronary peripheral atherosclerosis, most likely due the antioxidant anti-inflammatory activities of bilirubin. The aim present study was assess markers oxidative in both healthy subjects patients with various forms atherosclerosis. performed premature myocardial infarction (n = 129), chronic ischemic heart disease 43), artery...
The primary aim was to determine frequencies of mutations related risk venous thrombosis in healthy Caucasians Central Bohemia. In a cohort 1527 individuals the frequency alleles for FV Leiden and FII 20210G>A 4.5% 1.3%, respectively. Frequency 4G PAI-1 allele 55.5%. Genotype were: GG 91.03%, GA 8.91%, AA 0.07% Leiden; 97.45%, 2.49%, 20210G>A; 4G/4G 30.26%, 4G/5G 50.56%, 5G/5G 19.19% PAI-1. A polymorphism SERPINC1 (IVS +141G >A) 11.3%, genotypes were as follows: 78.36%, 20.66%, 0.98%. T GP6...
The objective of our study was to examine the changes in coagulation parameters and inflammatory reaction over course 15 days patients with severe sepsis. We tried identify mechanisms by which sepsis-induced pathophysiological may influence effectiveness subcutaneously (SC) administered enoxaparin 40 mg once daily. A total 16 (8 men, 8 women; age 35-83 years) meeting inclusion criteria sepsis were enrolled this study. follow-up performed on 1, 2, 3, 6, 9, 12, hospitalization at intensive...
Endothelial activation and dysfunction may play a significant role in the progression of breast cancer. In our study we examined markers endothelial (soluble ICAM-1, P-selectin, E-selectin) 98 young patients with cancer (< 40 years). 50 them (and 20 age-matched controls) also measured flow mediated vasodilation. Patients had significantly higher serum levels soluble E-selectin, P-selectin was larger tumors, node involvement seemed to be apredictor poor outcome. We were unable find difference...
Fondaparinux exhibits a similar mechanism of action as LMWH. Since both these drugs bind to antithrombin and increase its affinity factor Xa, fondaparinux is not expected be an effective alternative anticoagulant LMWH in case resistance.We report on anticoagulation using following total unresponsiveness high doses nadroparin administered twice daily, confirmed via repeated anti-Xa measurements. The levels were within the normal range.To best our knowledge, this first use
The cases of antithrombin (AT)-deficient pregnant women with a homozygous HBS II mutation are relatively rare and accompanied by an increased thrombophilic risk, which is manifested thrombin generation (TG). It very difficult to ensure their prophylactic treatment during pregnancy. We aimed determine the utility assay (TGA) anti-factor Xa (anti-FXa) test monitor effects dose low-molecular-weight heparin (LMWH) in 28-year-old woman AT deficiency caused c.391C > T#, (p.Leu131Phe†) SERPINC1...
We present the case study of a 28-year-old pregnant woman with antithrombin deficiency who was treated low-molecular-weight heparin (LMWH).Due to severe homozygous type II binding site (HBS) deficiency, thrombin generation (TG) monitored in this via Thrombin Generation Assay (TGA). used Siemens diagnostic kits Berichrom® Antithrombin III (IIa) and INNOVANCE® (Xa) determine activity. chromogenic method for determination factor Xa (FXa) inhibition.There were no thrombotic complications during...
<b><i>Objectives:</i></b> There is a major problem in providing prophylactic treatment antithrombin (AT)-deficient pregnant women with homozygous mutation of the heparin-binding site and AT level 17%. The aim study was to determine effectiveness heparin by monitoring changes thrombin generation (TG) vitro so that are not exposed stress vivo. <b><i>Methods:</i></b> We used chromogenic method for determination factor Xa (FXa) inhibition...