Background Frailty has been associated with a greater risk of complications and higher treatment costs for various medical conditions surgical procedures. The Modified Index, which analyzes five or six comorbidities, helps grade the severity patient’s frailty. Patients frailty, as recognized by this index, are more likely to face adverse events after total shoulder arthroplasty (TSA). However, these modified indices often do not consider less common that contribute As such, we believe...

Germline stem cell (GSC) self-renewal and differentiation into gametes is regulated by both intrinsic factors in the germ line as well extrinsic from surrounding somatic niche. dWnt4, escort cells of adult niche promotes GSC using canonical β-catenin-dependent transcriptional pathway to regulate survival, adhesion downregulation signaling. Here, we show that addition pathway, dWnt4 also uses downstream components Wnt non-canonical promote function earlier development. We find components,...

Background: The purpose of this study was to assess the effectiveness an Artificial Intelligence-Large Language Model (AI-LLM) at improving readability hand and wrist radiology reports. Methods: reports 100 and/or radiographs, computed tomography (CT) scans, magnetic resonance imaging (MRI) scans were extracted. following prompt command inserted into AI-LLM: “Explain report a patient in layman’s terms second person: [Report Text].” length, Flesch reading ease score (FRES), Flesch-Kincaid...

Total shoulder arthroplasty (TSA) with a nonspherical humeral head component and inlay glenoid is successful bone-preserving treatment for glenohumeral arthritis. This study aimed to describe the 90-day complication profile of TSA this prosthesis compare major minor readmission rates between inpatient- outpatient-procedure patients.A retrospective review was performed consecutive cohort patients undergoing in inpatient outpatient settings by single surgeon 2017 2022. Age, sex, body mass...

Background: The coronavirus disease 2019 (COVID-19) pandemic has disrupted the American economy and healthcare system. aim of our observational retrospective cohort study was to evaluate short-term effect orthopaedic surgical volume at a large tertiary care center. We hypothesized slow resurgence in

Total shoulder arthroplasty with a humeral head resurfacing (HHR) component and an inlay glenoid (OVOMotion; Arthrosurface) is successful treatment option for patients advanced glenohumeral arthritis, intact rotator cuff, adequate proximal bone stock. In poor bone, historically stemmed components have been used instead of HHR. However, strategies can be to successfully optimize HHR implant fixation in suboptimal without converting implants or surgical centers where prostheses are not...

Background Total shoulder arthroplasty (TSA) with a nonspherical humeral head component and inlay glenoid is bone preserving treatment for glenohumeral arthritis. This study aims to describe minimum two year patient reported outcomes, acceptable symptomatic state (PASS) achievement, complications following TSA this prosthesis. Methods A retrospective review of patients undergoing was performed. Outcomes included Single Assessment Numeric Evaluation (SANE) scores, American Shoulder Elbow...

Case: We report a case of lesser tuberosity avulsion fracture in 14-year-old adolescent boy who presented to Orthopaedic Urgent Care where he was promptly diagnosed after magnetic resonance imaging. The patient successfully treated with an open transosseous equivalent suture repair 3 weeks initial injury. Conclusion: purpose this advance the understanding these injuries, enable appropriate diagnosis and treatment, optimize patient's shoulder outcomes return sport.

Abstract Introduction: Alpha-fetoprotein (AFP) functions in utero to inhibit estrogen-mediated growth fetal tissue. AFPep is a 9-amino acid cyclized form of the active site AFP that impedes phosphorylation and activation ERα. Recent studies demonstrate inhibits estrogen-dependent MCF-7 T47D xenografts decreases mammary tumor burden estrogen-exposed ACI rats. It important identify biomarkers predict efficacy AFPep. Dimerized, phosphorylated ERα (pERα) transcribes TRIM25, which associated with...

INTRODUCTION: We present cases of esophageal motility disorders associated with sleeve gastrectomy and identify the role high-resolution manometry (HRM) in perioperative diagnosis management. CASE DESCRIPTION/METHODS: Case 1: A 44-year old female history morbid obesity gastric reflux presented persistent symptoms regurgitation, vomiting, refractory after undergoing a two years prior. Upper endoscopy showed slight resistance to endoscope passage at lower sphincter HRM evaluation was...

Introduction: Alpha-fetoprotein (AFP) functions in utero to inhibit estrogen-mediated growth fetal tissue. AFPep is a 9-amino acid cyclized form of the active site AFP that impedes phosphorylation and activation ERα. Recent studies demonstrate inhibits estrogen-dependent MCF-7 T47D xenografts decreases mammary tumor burden estrogen-exposed ACI rats. It important identify biomarkers predict efficacy AFPep. Dimerized, phosphorylated ERα (pERα) transcribes TRIM25, which associated with breast...