A5077980376- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Histone Deacetylase Inhibitors Research
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Inflammatory mediators and NSAID effects
- Nanocluster Synthesis and Applications
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Organometallic Complex Synthesis and Catalysis
- Advanced biosensing and bioanalysis techniques
- Lanthanide and Transition Metal Complexes
- Magnetism in coordination complexes
- Protein Interaction Studies and Fluorescence Analysis
- Catalytic C–H Functionalization Methods
- Synthesis of Tetrazole Derivatives
- Catalytic Alkyne Reactions
- GDF15 and Related Biomarkers
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2017-2021
Azienda Sanitaria Locale Alessandria
2017-2021
The synthesis, characterization, and in vitro activity of a cyclohexane-1 R,2 R-diamine-based Pt(IV) derivative containing the histone deacetylase inhibitor rac-2-(2-propynyl)octanoato, namely, ( OC-6-44)-acetatodichlorido(cyclohexane-1 R-diamine)( rac-2-(2-propynyl)octanoato)platinum(IV), are reported together with those its isomers enantiomerically enriched axial ligands. These complexes showed comparable activity, 2 orders magnitude higher than reference drug oxaliplatin on three human...
The design, synthesis, characterization and biological properties of a Pt(iv) complex containing the very active inhibitor histone deacetylase (2-propynyl)octanoic acid, POA, as an axial ligand are reported here. title complex, namely (OC-6-44)-acetatodiamminedichlorido(2-(2-propynyl)octanoato)platinum(iv), 1, POA in racemic or enantiomeric forms, was one/two orders magnitude more than cisplatin, depending on chemo-sensitivity cancer cell lines. Moreover, 1 exhibited similar even better...
Cisplatin and several non-steroidal anti-inflammatory drugs (NSAIDs) have been proven to act synergistically or at least additively on tumor cell lines. Dual-action cisplatin-based Pt(IV) combos containing ketoprofen naproxen offer good antiproliferative performance a panel of human lines, including malignant pleural mesothelioma (MPM) one, very chemoresistant tumor. The main reason the increased activity relies enhanced lipophilicity these conjugates that in turn promotes cellular...
Cyclohexane-1<italic>R</italic>,2<italic>R</italic>-diamine carrier ligand increases the selectivity towards colon cancer cells with respect to diamines in asymmetrical (acetato)(carboxylato)platinum(<sc>iv</sc>) prodrugs.
The insertion of perillic acid in cisplatin-based antitumor Pt(<sc>iv</sc>) prodrugs confers them antimetastatic properties.
The Pt(iv) complexes based on (SP-4-2)-dichlorido(cyclohexane-1,4-diamine)platinum(ii) (kiteplatin) and the histone deacetylase inhibitor 2-(2-propynyl)octanoic acid (POA) were investigated. Since POA contains a chiral carbon, all possible isomers prepared characterized, their antiproliferative activity six cancer cell lines was compared with that of corresponding containing cyclohexane-1R,2R-diamine equatorial ligand. To justify very good (nanomolar IC50), polarity, lipophilicity,...
Oxidation of [Pt(II)Cl(terpy)]+ (terpy = 2,2':6',2''-terpyridine) has been attempted with several oxidizing agents and under different experimental conditions in order to obtain a Pt(iv) complex suitable for the conjugation nanovectors be used drug delivery targeting anticancer therapy. The best compromise terms yield purity final was obtained by microwave-assisted reaction at 70 °C 50% aqueous H2O2 2 h. Under these quantitative formation [Pt(IV)Cl(OH)2(terpy)]+ observed. subsequent...
The possibility of spontaneous self-assembly dicarboxylato Pt(IV) prodrugs and the consequences on their uptake in cancer cells have been evaluated different aqueous solutions. Four complexes, namely, (OC-6-33)-diacetatodiamminedichloridoplatinum(IV), Ace, (OC-6-33)-diamminedibutanoatodichloridoplatinum(IV), But, (OC-6-33)-diamminedichloridodihexanoatoplatinum(IV), Hex, (OC-6-33)-diamminedichloridodioctanoatoplatinum(IV), Oct, dispersed i) milliQ water, ii) phosphate buffered saline, iii)...