A5054763735- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- interferon and immune responses
- RNA and protein synthesis mechanisms
University of South Alabama
2021-2023
SnoRNAs are frequently processed into snoRNA-derived RNAs (sdRNAs) that function much like traditional microRNAs (miRNAs). That said, our analyses suggest a global switch from DICER-dependent (predominately miRNA) to DICER-independent sdRNA) biogenesis/gene regulation in colon cancer. Whereas the expressions of 259 288 appreciably expressed miRNAs significantly decreased (avg. 6.4% WT) human cancer DICER-KOs, 95 103 sdRNAs conversely, increased 679.3%) DICER-KOs as compared WT. As many...
In the past decade, RNA fragments derived from full length small nucleolar RNAs (snoRNAs) have been shown to be specifically excised and functional. These sno-derived (sdRNAs) implicated as gene regulators in a multitude of cancers, controlling variety genes post-transcriptionally via association with RNA-induced silencing complex (RISC). this review, we summarized literature connecting sdRNAs cancer regulation. SdRNAs possess miRNA-like functions, are able fill role tumor-suppressor or...
Abstract Salmonella Outer Membrane Vesicles (OMVs) were recently shown to inhibit P22 bacteriophage infection. Interestingly, we identify 31 recurrent tRFs abundantly expressed by enterica serovar Typhimurium and find these are highly complementary known -infecting (17 averaging 97.4% complementarity over 22.9 nt) specifically enriched in S. OMVs. Most notably, tRNA-Thr-CGT-1-1, 44-73, bears 100% its entire 30 nt length 29 distinct including P22. Importantly, inhibiting this tRF secreted...
ABSTRACT Salmonella Outer Membrane Vesicles (OMVs) were recently shown to inhibit P22 bacteriophage infection. Furthermore, despite there being several published reports now independently describing (1) the marked prevalence of tRFs within secreted vesicle transcriptomes and (2) roles for specific in facilitating/inhibiting viral replication, have been no examinations effects vesicle-secreted on infection reported date. Notably, while a number bacteria, expressed by salmonellae not...