A5077998877- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Bacteriophages and microbial interactions
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Pneumonia and Respiratory Infections
- Advanced Drug Delivery Systems
- Peptidase Inhibition and Analysis
- Dendrimers and Hyperbranched Polymers
- Computational Drug Discovery Methods
- CRISPR and Genetic Engineering
- Nanoplatforms for cancer theranostics
- DNA and Nucleic Acid Chemistry
- Respiratory viral infections research
- Cancer Research and Treatments
- Transgenic Plants and Applications
- CAR-T cell therapy research
- Pharmacogenetics and Drug Metabolism
- Carbon and Quantum Dots Applications
- Nausea and vomiting management
- Plant Virus Research Studies
- Curcumin's Biomedical Applications
Shiraz University of Medical Sciences
2016-2025
Yasuj University of Medical Sciences
2023
Canadian International College
2023
Cape Breton University
2023
Tabriz University of Medical Sciences
2023
Pharmaceutical Biotechnology (Czechia)
2017
Mashhad University of Medical Sciences
2008-2011
Biotechnology Research Center
2008-2010
Ludwig-Maximilians-Universität München
2008
Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In current study, we generated a number of nontoxic derivates branched through modification amines by ethyl acrylate, acetylation primary amines, or introduction negatively charged propionic acid succinic groups polymer structure. The resulting products showed high siRNA-mediated knockdown target gene. particular, succinylation resulted up 10-fold lower...
Streptococcus pneumoniae is a leading cause of some diseases such as pneumonia, sepsis, and meningitis mostly in children less than 5 years age. Presently, two types pneumococcal vaccine are available on the market: polysaccharide vaccines (PPV) that based capsular polysaccharides at least 92 different serotypes, protein-conjugated (PCV). The PPVs PPV23 do not stimulate efficient protective immunity under 2 old, while PCVs PCV7, PCV10, PCV13 cover 7, 10, 13 respectively, highly protect...
There is an increasing interest in the nanostructured polysaccharide-iron hydrogel produced by Klebsiella oxytoca. Critical physicochemical and biological characteristics of these nanostructures should be revealed for biomedical applications. Accordingly, iron reducing strain K. oxytoca, which synthesizes biogenic nanoparticles, known as Fe (III)-exopolysaccharide (Fe-EPS) was isolated from a mineral spring. For microbiological identification purpose 16S rRNA sequence analysis different...
Selenium nanoparticles (SeNPs) are well-known bioactive compounds. Various chemical and biological methods have been applied to SeNP synthesis. Spirulina platensis is a widely used blue-green microalgae in various industries. In this study, the biosynthesis of SeNPs using sodium selenite platens has developed. The synthesis was performed at different cultivation condition including pH illumination schedule variation. were characterized by FT-IR, XRD, size, zeta potential measurements,...
Various strategies have been examined to improve both transfection efficiency and cytotoxicity of polyethylenimine (PEI), a widely used polycationic nonviral gene vector. In the present study, we sought PEI by combining osmotic burst mechanism for lysing endocytotic vesicles with lipid depletion mechanism, which was accomplished maintaining buffering capacity at same time as adding lipid-absorbing hydrophobic shell.PEI altered via substitution various percentages its primary amines...
Abstract Background Carboxyalkylation of branched 25 kDa polyethylenimine (PEI) was considered to reduce the positive surface charge polymer without reducing its ‘proton sponge’ buffering capacity, and provide alkylene domains for hydrophobic interactions, thus generating optimized novel PEI carriers efficient delivery small interfering RNA (siRNA). Methods Substitution evaluated in range 6 > 50 mole percentage primary amines. Additionally, variation carboxyalkyl chain (one 15 methylene...
Various strategies have been utilized to improve both gene transfer efficiency and cell-induced toxicity of polyethylenimine (PEI), the most extensively investigated cationic polymeric vector. In this study, we sought enhance transfection low molecular weight PEI (LMW PEI) while maintaining its by cross-linking LMW via succinic acid linker. These modifications were designed hydrophilic-hydrophobic balance polymer, enhancing buffering capacity cytotoxic effects final conjugate. Decreased...