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Maite G Fernandez-Barrena

ORCID: 0000-0003-4459-5301
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About
Contact & Profiles
A5114672966
Research Areas
  • Liver physiology and pathology
  • Organ Transplantation Techniques and Outcomes
  • Pediatric Hepatobiliary Diseases and Treatments

Centro de Investigación Biomédica en Red
 2020

 Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis
OPENALEX - Publications 
Marina Bárcena‐Varela Hannah L. Paish Laura Álvarez Iker Uriarte María U. Latasa and 21 more Eva Santamaría Miriam Recalde Maria Rosa Garate Alex Clavería-Cabello Leticia Colyn María Arechederra María J. Iraburu Małgorzata Milkiewicz Piotr Milkiewicz Bruno Sangro Stuart Robinson Jeremy French Ana Pardo–Saganta Julen Oyarzábal Felipe Prósper Krista Rombouts Fiona Oakley Jelena Mann Carmen Berasain Matías A. Ávila Maite G Fernandez-Barrena

Hepatic stellate cells (HSC) transdifferentiation into myofibroblasts is central to fibrogenesis. Epigenetic mechanisms, including histone and DNA methylation, play a key role in this process. Concerted action between DNA-mehyltransferases like G9a DNMT1 common theme gene expression regulation. We aimed study the efficacy of CM272, first-in-class dual reversible G9a/DNMT1 inhibitor, halting fibrogenesis.G9a were analysed cirrhotic human livers, mouse models liver fibrosis cultured HSC. was...

10.1136/gutjnl-2019-320205 article EN Gut 2020-04-23
 SAT-083-YI Clinical potential and non-canonical roles of the cytosolic aspartyl-tRNA synthetase (DARS1) in hepatocellular carcinoma
OPENALEX - Publications 
Natalia Hermán‐Sánchez Maite G Fernandez-Barrena Iker Uriarte Matías A. Ávila Raúl M. Luque and 3 more Manuel Rodríguez‐Perálvarez Juan L López-Cánovas Manuel D. Gahete

10.1016/s0168-8278(25)01283-8 article EN Journal of Hepatology 2025-05-01
 SAT-064 Expression and role of trefoil factor 3 (TFF3) in hepatoblastoma
OPENALEX - Publications 
Luz Andrea Martínez‐Pérez María U. Latasa Melva Gutiérrez‐Angulo Iker Uriarte Amaya López-Pascual and 16 more Jasmin Elurbide-Tardio Pavel Strnad Sonèa Franèková Ondrej Fabiánè María Arechederra Eva Santamaría Josepmaria Argemi Bruno Sangro Ramon Bataller Carmen Berasain Pau Sancho‐Bru María Luz Martínez‐Chantar José J.G. Marı́n Carolina Armengol Maite G Fernandez-Barrena Matías A. Ávila

10.1016/s0168-8278(25)01274-7 article EN Journal of Hepatology 2025-05-01
 THU-487 Liver-targeted mRNA therapeutics through fibroblast growth factor 21 and apolipoprotein A1 delivery in experimental acute pancreatitis
OPENALEX - Publications 
Amaya López-Pascual Eva Santamaría Nuria Ardaiz Iker Uriarte Tiffany Palmer and 14 more Anne-Renee Graham Celia Gomar Roberto Escudero Barbero María U. Latasa María Arechederra Jesús Urmán Carmen Berasain Antonio Fontanellas Carlos del Río Maite G Fernandez-Barrena Paolo G.V. Martini Joshua R. Schultz Pedro Berraondo Matías A. Ávila

10.1016/s0168-8278(25)00501-x article EN Journal of Hepatology 2025-05-01
 THU-115-YI Targeting UBE2I-mediated protein hyper-SUMOylation halts cholangiocarcinoma progression and rewires the tumor-stroma crosstalk
OPENALEX - Publications 
Irene Olaizola Paula Olaizola Marta Fernández de Ara Ainhoa Lapitz Laura Izquierdo-Sánchez and 20 more Maite G Fernandez-Barrena Laura Álvarez Colm O Rourke Pui-Yuen Lee-Law Kyle Davies Andreea Grãdinaru Raúl Jiménez-Agüero Adelaida La Casta Ioana Riaño Rocı́o I.R. Macı́as José J.G. Marı́n María Luz Martínez‐Chantar Matías A. Ávila Patricia Aspichueta Jesper N. Andersen Luke Boulter Luís Bujanda Pedro M. Rodrigues María J. Perugorria Jesús M. Bañales

10.1016/s0168-8278(25)01265-6 article EN Journal of Hepatology 2025-05-01
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