Nils Eickhoff
A5085704728- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Prostate Cancer Treatment and Research
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Dietary Effects on Health
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- PARP inhibition in cancer therapy
Oncode Institute
2021-2025
The Netherlands Cancer Institute
2021-2025
In prostate cancer, androgen receptor (AR)-targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before after 3 months of AR-targeting enzalutamide monotherapy from patients with high-risk cancer enrolled a neoadjuvant clinical trial. Transcriptomic demonstrated that inhibition drove tumors...
The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, detailed effect on AR biology has been described for number of interacting proteins, many coregulators remain to be characterized in relation their distinct impact function. Here, we describe TRIM33 as conserved AR-interactor across multiple cell lines. We observed share overall chromatin interaction profiles, which involved downstream responsive...
Abstract The androgen receptor (AR) is the critical driver in prostate cancer and exerts its function mainly through transcriptional control. Recent advances clinical studies cell line models have illustrated that AR chromatin binding features are not static; rather they highly variable yet reproducibly altered between stages. Extensive genomic analyses of different disease stages revealed a high degree plasticity interactions samples. Mechanistically, patterns associated with specific...
<div>Abstract<p>In prostate cancer, androgen receptor (AR)–targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before after 3 months of AR-targeting enzalutamide monotherapy from patients with high-risk cancer enrolled a neoadjuvant clinical trial. Transcriptomic demonstrated that...
<div>Abstract<p>In prostate cancer, androgen receptor (AR)–targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before after 3 months of AR-targeting enzalutamide monotherapy from patients with high-risk cancer enrolled a neoadjuvant clinical trial. Transcriptomic demonstrated that...
Supplementary Data from Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence
Supplementary Figure from Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence
Supplementary Figure from Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence
Supplementary Data from Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence
p300 is an important transcriptional co-factor. By stimulating the transfer of acetyl residues onto histones and several key transcription factors, enhances initiation impacts cellular processes including cell proliferation division. Despite its importance for homeostasis, regulation poorly understood. We show that TRIM25, a member TRIM protein family, targets proteasomal degradation. However, despite TRIM25’s RING domain E3 activity, degradation by TRIM25 independent TRIM25-mediated...