Background Municipal drinking water contaminated with perfluorinated alkyl acids had been distributed to one-third of households in Ronneby, Sweden. The source was firefighting foam used a nearby airfield since the mid-1980s. Clean provided from 16 December 2013. Objective To determine rates decline serum perfluorohexane sulfonate (PFHxS), perfluorooctane (PFOS) and perfluorooctanoate (PFOA), their corresponding half-lives. Methods Up seven blood samples were collected between June 2014...

Abstract Background Exposures to perfluoroalkyl substances (PFAS) have shown positive associations with serum lipids in previous studies. While many studies on investigated perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic (PFOA), there are only a few regarding other PFAS, such as perfluorohexane (PFHxS). The purpose of the current study is investigate if were present, not for PFOS PFOA, but also PFHxS, PFAS remained comparison based residency areas contrasting exposure PFAS....

Per- and polyfluoroalkyl substances (PFAS) are extremely persistent manmade substances. Apart from exposure through food indoor air dust, humans can be exposed drinking water if the surface or groundwater is contaminated. In 2013 very high levels of PFOS PFHxS were found in one two waterworks supplying municipality Ronneby, Sweden. A cohort was formed, including all individuals who had lived at least year Ronneby during period 1980–2013 (ñ63,000). Each year, addresses that got their...

Perfluoroalkyl substances (PFAS) are widespread synthetic with various adverse health effects. Not much is known about the modes of action PFAS toxicity, but one likely mechanism alteration microRNA expression. To investigate whether exposure associated altered expression in serum. We selected women from Ronneby cohort, high to perfluorooctane sulfonic acid (PFOS) and perfluorohexane (PFHxS), emanating drinking water contaminated by firefighting foam, a control group neighbouring...

Perfluoroalkyl substances (PFAS) can act as surfactants and have been suggested to be capable of affecting gut mucosa integrity, a possible factor in the pathogenesis inflammatory bowel disease (IBD). So far, only PFOA has shown positive association with ulcerative colitis. The present study aimed investigate PFAS clinically diagnosed IBD Ronneby cohort, population high exposure (especially PFOS PFHxS) from Aqueous Film-Forming Foam through drinking water, using registry data. Additionally,...

Perfluoroalkyl substances (PFAS) are widespread synthetic with various adverse health effects. A potential mechanism of toxicity for PFAS is via epigenetic changes, such as DNA methylation. However, few studies have evaluated associations between exposure and methylation among adults, data especially scarce women. Furthermore, to environmental pollutants has been associated age acceleration, but no yet whether acceleration.To investigate alteration acceleration women.In this observational...

OPS 25: Drinking water contamination and adult health, Room 411, Floor 4, August 26, 2019, 10:30 AM - 12:00 PM Background/Aim: Per- polyfluoroalkyl substances (PFAS) comprise a group of many different substance that been produced widely used. They have reported in humans wildlife. The purpose this observational study was to estimate the elimination half-life PFAS from human serum after end exposure contaminated drinking water. Method: Municipal with had distributed one third households...

BACKGROUND: Extensive exposure to per-and polyfluoroalkyl substances (PFAS) have been observed in many countries.Current deterministic frameworks for risk assessment lack the ability predict likelihood of effects and assess uncertainty.When exceeds tolerable intake levels, these shortcomings hamper management communication.OBJECTIVE: The integrated probabilistic (IPRA) combines dose-response data estimate adverse effects.We evaluated usefulness IPRA characterization related decreased levels...

Background Maldescended testes or cryptorchidism is a genital birth defect that affects 2–9% of all male new-borns. Over the last 40 years there have been reports increased prevalence in countries like US, UK and Scandinavian countries. This possible increase has some studies linked to foetal exposure chemical pollutants. In this matched case-control study, we analysed maternal serum samples early pregnancy for three different organochlorine compounds, investigate whether levels were...

summary Measurements were made of the coer remaining on used Gravigard intrauterine contraceptive devices (lUCDs) that had been in utero for up to 40 months. The topography and composition surface deposits analysed by scanning electron microscopy energy‐dispersive X‐ray analysis. rate loss decreased exponentially from 0–42 μmol d −1 (26–7 μg ) upon insertion 0‐056 μimol (3–6 after 26 months use; between 27 use a linear release 0–32 (20–3 was observed. There no correlation this changing...

Per- and polyfluorinated compounds (PFASs) have endocrine disrupting properties. Alterations in thyroid hormone homeostasis also been observed animal experimental studies, some cross-sectional studies the general population, often with ambiguous results, data for other PFASs than PFOA PFOS is scarce.In December 2013 high levels of were detected one out two waterworks Ronneby, a municipality 28000 inhabitants. This supplied 1/3 households. The source was groundwater contamination from...

Abstract Background Osteoporosis is a common skeletal disease. Previous research has been primarily based on non-prospective designs, and rarely included male and/or migrant populations. We investigated the associations of sociodemographic characteristics with risk osteoporosis in Swedish nationwide cohort. Methods This register-based prospective study 1,900,279 males 1,961,619 females born 1920-1960, followed for from age 50 until December 31, 2012. Multivariable Cox regression was used to...

BackgroundIn Ronneby, Sweden, the use of fire fighting foam at a military airfield has resulted in leakage perfluorinated substances (PFAS) into drinking water for part population. A population sample from Ronneby had median serum levels PFOS, PFHxS and PFOA 176, 152 10 ng/ml respectively.Materials methodsAll individuals who ever lived municipality during 1980-2013 were included cohort. Each household was supplied by one two waterworks, which contaminated. time-varying exposure assessed,...

OPS 25: Drinking water contamination and adult health, Room 411, Floor 4, August 26, 2019, 10:30 AM - 12:00 PM Background: Per- polyfluoroalkyl substances (PFAS) can act as surfactants have been suggested to be capable of affecting gut mucosa integrity, a possible pathogenesis ulcerative colitis (UC), Crohn's Disease (CD) other inflammatory bowel disease (IBD). So far, only perfluorooctanoic acid (PFOA) has shown potential positive association with UC. Objectives: To investigate the...

OPS 15: Chemicals and pregnancy, Room 114, Floor 1, August 26, 2019, 10:30 AM - 12:00 PM Background: Previous studies examining associations between poly- perfluorinated alkyl substances (PFAS) preeclampsia have shown inconsistent results. In 2013, high levels of perfluorooctane sulfonate (PFOS), perfluorohexane (PFHxS) perfluorooctanoic acid (PFOA) were detected in the municipal drinking water Ronneby, Blekinge county, Sweden. The contamination had likely been ongoing for 30 years. This...

360 Commercially available creatine supplements can contain substantial quantities of carbohydrates. The purpose this study was to determine if consuming a carbohydrate containing supplement affected the dietary intake trained university swimmers. Fourteen swimmers completed supplementation protocol beverages either 21g monohydrate and 136g dextrose (Cr)(Phosphagen HP, EAS Golden, CO) or placebo (P)(136g dextrose) for five days (loading phase). Three day food records were collected prior...