A5109875867- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Neutropenia and Cancer Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Pharmaceutical studies and practices
- Mycobacterium research and diagnosis
- Antimicrobial Resistance in Staphylococcus
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- Urinary Tract Infections Management
- Drug-Induced Adverse Reactions
- Reproductive tract infections research
- Pneumonia and Respiratory Infections
- Health and Medical Studies
- Libraries and Information Services
- Blood disorders and treatments
- HIV/AIDS Research and Interventions
- Fungal Infections and Studies
- Hematological disorders and diagnostics
- HIV/AIDS drug development and treatment
- Syphilis Diagnosis and Treatment
Technical University of Darmstadt
2002-2023
Thüringer Universitäts- und Landesbibliothek
2018-2021
Goethe University Frankfurt
1994-2009
Klinikum Kassel
2000
University Hospital Frankfurt
1983-1996
University Medical Center Hamburg-Eppendorf
1995
University of Cologne
1995
Universität Hamburg
1995
Heinrich Heine University Düsseldorf
1995
Düsseldorf University Hospital
1995
Objective To evaluate the efficacy and safety of zidovudine (ZDV) at a maintenance dose 250 mg every 6 h alone or as cotherapy with acyclovir (ACV; 800 h) treatment for AIDS AIDS-related complex (ARC). Design Double-blind, randomized, placebo-controlled clinical trial up to 1 year's therapy. Setting Teaching hospital ambulatory clinics in eight European countries Australia. Subjects A total 131 patients 134 ARC were enrolled followed from 1986 1988. Main outcome measures Time development...
543 persons in AIDS risk groups were examined for LAV/HTLV-III infection. Antibodies against demonstrated 377, during an observation period of 3 months to years. Patients divided into 5 groups, according clinical, serological and immunological criteria. Severity symptoms incidence recurrences the lymphadenopathy syndrome correlated positively with increase cellular immune deficiency. At end only 30 307 antibody-positive patients well. The all increased time from 3% (6-11 months) 19.4% (24-36...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
In investigations into the dosis-activity relationships of bactericidal antibiotics used against E. coli, K. pneumoniae and Staph. aureus four types activity could be demonstrated. The penicillin type shows almost no improvement in despite increasing dosage above a certain level. An increase concentration aminoglycoside led to more rapid killing bacteria. cefalotin there was linear relationship: rising concentrations an ever effect. paradoxical effect ("Eagle effect'') described for G with...
Journal Article Combination Therapy with Zidovudine Prevents Selection of Human Immunodeficiency Virus Type 1 Variants Expressing High-Level Resistance to L-697,661, a Nonnucleoside Reverse Transcriptase Inhibitor Get access S. Staszewski, Staszewski Search for other works by this author on: Oxford Academic PubMed Google Scholar F. E. Massari, Massari A. Kober, Kober R. Göhler, Göhler Durr, Durr K. W. Anderson, Anderson C. L. Schneider, Schneider J. Waterbury, Waterbury Bakshi, Bakshi V. I....
The efficacy of oral itraconazole 2 × 200 mg capsules daily for prevention systemic mycoses was investigated in granulocytopenic patients with haematological malignancies. Of 241 patients, 197 were evaluable prophylactic efficacy, and 214 adverse events. Patients similar characteristics receiving amphotencin B as antifungal prophylaxis, observed over 15 months before introduction itraconazole, served control group (n = 223). With 13 cases aspergillosis (9 proven, 1 probable, 3 possible; 7%)...
The single dose pharmacokinetics of caffeine (220-230 mg per dose) were investigated in 12 healthy male volunteers before and during treatment with ofloxacin (200 bd), ciprofloxacin (250 bd) enoxacin (400 a cross-over study design. None the parameters: mean elimination half-life (T1/2el), Cmax, total body clearance (Cltot) volume distribution (aVd) noticeably altered by administration ofloxacin. Striking changes observed, however, after enoxacin: T1/2el was prolonged as much 260%, Cmax...
This was an open efficacy and safety study in 310 hospitalized patients (187 male 123 female) with infection by Gram-positive bacteria. The age range 12-88 years (mean 49.8 years), 80 of the were older than 65 years. Teicoplanin given either fast iv or im injection, most cases at a dose 200 400 mg every 24 h initial mg. For both routes administration mean total daily 286 +/- 5 mg/day. duration treatment 8.2 days (range 1-37 days). infections comprised 133 skin soft tissue, 53 joint bone, 40...