In current clinical practice, the diagnosis of cervical cancer (CC) is mainly through screening followed by a necessary biopsy, but this method labor consuming and expensive, can only detect superficial lesions around external orifice.In contrast, photoacoustic imaging (PAI) sensitive to abnormal angiogenesis deep in biological tissue, may be capable for intact scanning both orifice canal.In paper, we first time put forward CC.A total 30 invitro experiments were carried out study, obtained...

A Ga 2 S 3 /graphene/GaN based multifunctional photodetect-memristor was fabricated using a simple area selective deposition method. Simulations confirm the working mechanism and application feasibility.

Abstract Photodetectors (PDs) based on 2D transition metal dichalcogenides (2D TMDCs) heterojunction have become a potential candidate for frontier technology applications such as visible light communication (VLC). However, the conventional TMDCs PDs are facing problems with excessive dark current and low photoelectric conversion efficiency, resulting in performance of not meeting application requirements. Herein, controllable growth monocrystalline MoS 2 /polycrystalline ReS lateral via...

We present for the first time in vivo experimental evidence that quantitative photoacoustic tomography (qPAT) has potential to detect osteoarthritis (OA) finger joints. In this pilot study, 2 OA patients and 4 healthy volunteers were enrolled, their distal interphalangeal (DIP) joints examined photoacoustically by a PAT scanner. Tissue absorption coefficient images of all joints, which unavailable from conventional PAT, recovered using our finite element based qPAT approach. The revealed...

Melanoma is a common, highly fatal skin cancer. Photoacoustic imaging can achieve sensitive and high-contrast detection of melanin molecules in tissues, also inheriting the high penetration depth spatial resolution characteristics ultrasound imaging, thus it very promising non-invasive diagnostic tool for early melanoma. In this work, we built an acoustic-resolution-based photoacoustic microscopy system, using 1064 nm/532 nm pulsed light to observe melanoma back mouse with simultaneous...

Current artificial intelligence (AI) in histopathology typically specializes on a single task, resulting heavy workload of collecting and labeling sufficient number images for each type cancer. Heterogeneous transfer learning (HTL) is expected to alleviate the data bottlenecks establish models with performance comparable supervised (SL).An accurate source domain model was trained using 28,634 colorectal patches. Additionally, 1000 sentinel lymph node patches 1008 breast were used train two...

Currently, most transducers in photoacoustic endoscopy (PAE) are ceramic based, which complicated to fabricate and expensive. In this work, we have for the first time presented a hollow structured epoxy lens-focused transducer that was based on 52 μm thick polyvinylidine fluoride (PVDF) film purpose of PAE imaging. Intensive field characteristic tests were performed with different lens curvatures, results show 6 mm fixed aperture, lateral resolution less than 0.5 can be obtained focal length...

Among numerous active photocatalytic materials, Sn-based oxide nanomaterials are promising materials in environmental protection measures such as water remediation due to their excellent physicochemical property. Research on for photodegradation of methyl orange (MO) so far has focused TiO2-based nanostructures; e.g., TiO2-P25 is recognized be the best commercial photocatalyst date, rather than nanomaterials, spite impressive acid- and alkali-resistant properties high stability. Here, we...

While photoacoustic computed tomography (PACT) is generally built with planar transducers of finite size, most current reconstruction algorithms assume the transducer to be an ideal point, which leads a spinning blur in consequently obtained PACT images due model mismatch. In this work, we put forward improved back-projection method that factors geometry improve tangential resolution for 2D circular-scanning-based tomography. Extensive simulations and experiments were carried out study...

Neurovascular coupling in epilepsy is poorly understood; its study requires simultaneous monitoring of hemodynamic changes and neural activity the brain.Here for first time we present a combined real-time 3D photoacoustic tomography (PAT) electrophysiology/electroencephalography (EEG) system neurovascular epilepsy, whose ability was demonstrated with pentylenetetrazol (PTZ) induced generalized seizure model rats. Two groups experiments were carried out different wavelengths to detect...

Existing acoustic-resolution photoacoustic/ultrasonic endoscopy (PA/USE) generally employs a point-focused transducer for ultrasound detection, which is only sensitive in its focal region, thus the lateral resolution and sensitivity drop dramatically when targets move far from focus. Even if dynamic focusing algorithm applied, out of focus still much lower than that ultrasonic imaging mode. In this work, we propose an PA/USE with line-focused to realize automatic first time. comparison...

Purpose Acoustic resolution photoacoustic endoscopy (ARPAE) is an emerging tool for gastrointestinal tract and esophagus imaging. However, high over large depth of field in ARPAE still a challenge to be addressed due the usage fixed‐focus transducers. Methods To solve this problem, modified back‐projection reconstruction algorithm proposed work, which was demonstrated two dimensions (2D). By employing data from multiple transducer positions at meantime considering geometry detection surface,...

The back-projection algorithm is the most common method for reconstruction of circular-scanning-based photoacoustic tomography (CSPAT) due to its simplicity, computational efficiency, and robustness. It usually can be implemented in two models: one ideal point detector, other planar transducer with infinite element size. However, because transducers CSPAT are a finite size, off-center targets will blurred tangential direction these models.Here this paper, we put forward new model back...

Purpose In circular‐scanning‐based photoacoustic tomography (PAT), the effect of finite transducer aperture has not been effectively resolved. The goal this paper is to propose a practical reconstruction method that accounts for improve lateral resolution. Methods We first time calculate spatial‐temporal response (STR) employed finite‐sized in forward model, and then compensate delay directional sensitivity framework back‐projection method. Both simulation phantom experiments were carried...

Abstract Background Long noncoding RNAs (lncRNAs) are implicated in the tumor immunology of hepatocellular carcinoma (HCC). Methods HCC mRNA and lncRNA expression profiles were used to extract immune-related genes with ImmPort database, lncRNAs ImmLnc algorithm. The MOVICS package was cluster mRNA, lncRNA, gene mutation methylation data on from TCGA. GEO ICGC datasets validate model. Data single-cell sequencing determine model various immune cell types. Results With this model, area under...

Pump-probe-based photoacoustic tomography (PP-PAT) is an innovative and promising molecular imaging technique. In this study, we utilized PP-PAT for the first time, to best of our knowledge, monitor dynamics oxygen partial pressure (pO 2 ) within murine tumors during photodynamic therapy (PDT) with methylene blue (MB). We developed, a novel two-step fitting method simultaneously map both pO MB concentrations implemented it mexCuda accelerate pixel-wise-based calculation. The results...

Boosted electric field via enhanced dipoles, increased charge transmission towards the catalyst surface and promoted electron energy piezoelectric resulted in highly efficient photopiezocatalytic activity of ternary structures.

In this paper, a white-light full-field optical coherence tomography is developed to provide three-dimensional imaging of the development mouse embryo with ultrahigh-resolution. Spatial resolution 1.8 μm×1.12 μm (transverse×axial) achieved owing extremely short length light source and optimized compensation dispersion mismatch. A shot-noise limited detection sensitivity 80 dB obtained at an acquisition time 5 seconds per image. To enable in vivo development, homemade incubator applied...

Compared with commonly used analytical reconstruction methods, the frequency-domain finite element method (FEM) based approach has proven to be an accurate and flexible algorithm for photoacoustic tomography. However, FEM-based is computationally demanding, especially three-dimensional cases. To enhance algorithm's efficiency, in this work a parallel computational strategy implemented framework of using graphic-processing-unit frame named "compute unified device architecture." A series...

Acoustic resolution-based photoacoustic endoscopy (ARPAE) is a non-invasive potential tool for imaging gastrointestinal and urogenital tracts. However, current ARPAE systems usually only provide 2D sectorial B-mode images, have the limitation of image quality significantly deteriorating out-of-focus regions due to transducers with fixed focus in these systems. To overcome limitations, we put forward modified back-projection method that can 3D images dynamic focusing ARPAE.A graphics...