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Laura E. Pereira

ORCID: 0000-0003-4477-4166
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About
Contact & Profiles
A5050217797
Research Areas
  • Viral Infections and Vectors
  • Cancer, Hypoxia, and Metabolism
  • Immune Cell Function and Interaction
  • interferon and immune responses
  • Immune Response and Inflammation
  • Immune cells in cancer

Scripps Research Institute
 2020-2023

 Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic
OPENALEX - Publications 
Emily N. Chin Chenguang Yu Vincent F. Vartabedian Ying Jia M. N. Satish Kumar and 22 more Ana M. Gamo William F. Vernier Sabrina H. Ali Mildred Kissai Daniel C. Lazar Nhan Nguyen Laura E. Pereira Brent Benish Ashley K. Woods Sean B. Joseph Alan Chu Kristen Johnson Philipp N. Sander Francisco Martínez‐Peña Eric Hampton Travis S. Young Dennis W. Wolan Arnab K. Chatterjee Peter G. Schultz H. Michael Petrassi John R. Teijaro Luke L. Lairson

Targeting STING for cancer therapy Activation of the (stimulator interferon genes) protein by cyclic dinucleotide metabolites plays a critical role in antitumor immunity. The development synthetic agonists is therefore being pursued as strategy therapy, but inherent instability dinucleotides has limited current efforts. Pan et al. and Chin identified stable that act “closed” conformation similar to natural ligand, guanosine monophosphate–adenosine monophosphate (see Perspective Gajewski...

10.1126/science.abb4255 article EN Science 2020-08-21
 Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
OPENALEX - Publications 
Stephan H. Spangenberg Amelia Palermo Nathalia Gazaniga Francisco Martínez‐Peña Carlos Guijas and 9 more Emily N. Chin Markus M. Rinschen Philipp N. Sander Bill Webb Laura E. Pereira Ying Jia Lance Meitz Gary Siuzdak Luke L. Lairson

10.1016/j.chembiol.2023.06.016 article EN publisher-specific-oa Cell chemical biology 2023-07-18
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